专利检索 ap:("Akiji Asai" OR "Ivan Ban" OR "Samuel David" OR "Peter W. Thies") AND inv:"Samuel David" 第 4 页

31.

发明授权
2,9-Dioxatricyclo [4,3,1,0,3,7] decane derivatives, processes for their preparation and pharmaceutical compositions thereof 失效
标题翻译： 2,9-二氧杂环己烷（4,3,1,0,3,7）+0癸烷衍生物，其制备方法及其药物组合物

公开(公告)号：US4117148A

公开(公告)日：1978-09-26

申请号：US826681

申请日：1977-08-22

申请人： Peter Willibrord Thies , Samuel David

发明人： Peter Willibrord Thies , Samuel David

IPC分类号： C07D493/08 , A61K31/335

CPC分类号： C07D493/08

摘要： 3-AZIDOMETHYL-2,9-DIOXATRICYCLO[4,3,1,0.sup.3,7 ] DECANE DERIVATIVES ARE DISCLOSED WHICH EXHIBIT ANALGESIC, AS WELL AS ANTIPYRETIC AND ANTIPHLOGISTIC PROPERTIES, AND WHICH HAVE THE FORMULA (I) ##STR1## wherein: R.sub.1 represents alkyloxy or aralkyloxy;One of R.sub.2 and R.sub.3 is hydrogen and the other represents hydroxy, acyloxy or carbamyloxy, or R.sub.2 and R.sub.3 jointly represent oxygen; and,Y and y' each represent hydrogen or jointly form a bond,As well as pharmaceutical formulations thereof.By reducing the 3-azidomethyl compounds of formula (I), the corresponding 3-aminomethyl compounds are obtained which possess sedative properties and which are valuable intermediates for preparing 3-(mono- or dialkylaminomethyl)-2,9-dioxatricyclo[4,3,1,0.sup.3,7 ] decanes which exhibit sedative and soporific activities.