公开(公告)号：US08378085B2

公开(公告)日：2013-02-19

申请号：US13306255

申请日：2011-11-29

申请人： Koenraad Jozef Lodewijk Marcel Andries ,  Hinrich Wilhelm Helmut Gohlmann ,  Jean-Marc Edmond Fernand Marie Neefs ,  Peter Karel Maria Verhasselt ,  Johann Winkler ,  Marc Rene De Jonge ,  Lucien Maria Henricus Koymans

发明人： Koenraad Jozef Lodewijk Marcel Andries ,  Hinrich Wilhelm Helmut Gohlmann ,  Jean-Marc Edmond Fernand Marie Neefs ,  Peter Karel Maria Verhasselt ,  Johann Winkler ,  Marc Rene De Jonge ,  Lucien Maria Henricus Koymans

IPC分类号： C07H21/04 ,  C12Q1/00

CPC分类号： C07K14/35 ,  A61K38/00 ,  C12N9/14

摘要： This invention provides an isolated mutant atpE protein and departing from said mutant atpE protein the identification of an ATPase binding domain. This invention also provides related nucleic acids, vectors, host cells, pharmaceutical compositions and articles of manufacture. This invention further provides methods for determining whether a test compound interacts with an atpE protein, i.e. with the ATPase binding domain of the present invention, as well as pharmaceuticals compositions comprising said test compound, in particular as antimicrobials, more particular as antimycobacterial agent, even more particular for treating tuberculosis in a subject.

摘要翻译： 本发明提供了一种分离的突变型atpE蛋白，并从所述突变型atpE蛋白中脱离鉴定ATP酶结合结构域。 本发明还提供了相关的核酸，载体，宿主细胞，药物组合物和制品。 本发明还提供了用于确定测试化合物是否与atpE蛋白（即与本发明的ATP酶结合结构域）相互作用的方法，以及包含所述测试化合物，特别是作为抗微生物剂的药物组合物，更特别地作为抗分枝杆菌剂，甚至 更具体地用于治疗受试者的结核病。

公开(公告)号：US20120219964A1

公开(公告)日：2012-08-30

申请号：US13306255

申请日：2011-11-29

申请人： Koenraad Jozef Lodewijk Marcel Andries ,  Hinrich Wilhelm Helmut Göhlmann ,  Jean-Marc Edmond Fernand Marie Neefs ,  Peter Karel Maria Verhasselt ,  Johann Winkler ,  Marc Rene De Jonge ,  Lucien Maria Henricus Koymans

发明人： Koenraad Jozef Lodewijk Marcel Andries ,  Hinrich Wilhelm Helmut Göhlmann ,  Jean-Marc Edmond Fernand Marie Neefs ,  Peter Karel Maria Verhasselt ,  Johann Winkler ,  Marc Rene De Jonge ,  Lucien Maria Henricus Koymans

IPC分类号： G01N33/53 ,  C12N15/63 ,  C12N5/10 ,  C12N1/21 ,  C12N1/19 ,  C12N1/15 ,  C12N15/31 ,  C12Q1/02

CPC分类号： C07K14/35 ,  A61K38/00 ,  C12N9/14

摘要： This invention provides an isolated mutant atpE protein and departing from said mutant atpE protein the identification of an ATPase binding domain. This invention also provides related nucleic acids, vectors, host cells, pharmaceutical compositions and articles of manufacture. This invention further provides methods for determining whether a test compound interacts with an atpE protein, i.e. with the ATPase binding domain of the present invention, as well as pharmaceuticals compositions comprising said test compound, in particular as antimicrobials, more particular as antimycobacterial agent, even more particular for treating tuberculosis in a subject.

摘要翻译： 本发明提供了一种分离的突变型atpE蛋白，并从所述突变型atpE蛋白中脱离鉴定ATP酶结合结构域。 本发明还提供了相关的核酸，载体，宿主细胞，药物组合物和制品。 本发明还提供了用于确定测试化合物是否与atpE蛋白（即与本发明的ATP酶结合结构域）相互作用的方法，以及包含所述测试化合物，特别是作为抗微生物剂的药物组合物，更特别地作为抗分枝杆菌剂，甚至 更具体地用于治疗受试者的结核病。