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67 条记录 (耗时 0.039 秒)

    Nitric oxide releasing selective cyclooxygenase-2 inhibitors
    33.
    发明申请
    Nitric oxide releasing selective cyclooxygenase-2 inhibitors 审中-公开
    一氧化氮释放选择性环加氧酶-2抑制剂

    公开(公告)号：US20060058363A1

    公开(公告)日：2006-03-16

    申请号：US10530214

    申请日：2003-10-21

    申请人： Zhaoyin Wang ,  Robert Young ,  Robert Zamboni

    发明人： Zhaoyin Wang ,  Robert Young ,  Robert Zamboni

    IPC分类号： C07D261/06 ,  C07D231/12 ,  A61K31/42 ,  A61K31/415

    CPC分类号： C07D231/12 ,  C07D261/08

    摘要： The invention encompasses novel compounds of Formula (I) and Formula (II), which are nitric oxide-releasing prodrugs useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions and methods for treatment of cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula (I) or Formula (II). The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while simultaneously reducing the risk of thrombotic cardiovascular events.

    摘要翻译： 本发明包括式（I）和式（II）的新型化合物，其是用于治疗环加氧酶-2介导的疾病的一氧化氮释放前药。 本发明还包括用于治疗环氧合酶-2介导的疾病的某些药物组合物和方法，其包括使用式（I）或式（II）的化合物。 上述化合物可用作与低剂量阿司匹林联合治疗以治疗慢性环氧合酶-2介导的疾病或病症，同时降低血栓性心血管事件的风险。

    Indole derivatives as CRTH2 receptor antagonists
    37.
    发明授权
    Indole derivatives as CRTH2 receptor antagonists 有权
    吲哚衍生物作为CRTH2受体拮抗剂

    公开(公告)号：US08637541B2

    公开(公告)日：2014-01-28

    申请号：US13120076

    申请日：2009-09-17

    申请人： Zhaoyin Wang

    发明人： Zhaoyin Wang

    IPC分类号： A61K31/437 ,  C07D487/04

    CPC分类号： C07D471/04

    摘要： The compound (+) {7R-[[(4-fluorophenyl)sulfonyl] (methyl)ammo]-6,7,8,9-tetrahydropyrido[1,2-a]mdol-10-yl}acetic acid and pharmaceutically acceptable salts thereof are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-meidated diseases such as asthma.

    摘要翻译： 化合物（+）{7R - [[（4-氟苯基）磺酰基]（甲基）氨基] -6,7,8,9-四氢吡啶并[1,2-a]吗啉-10-基}乙酸和药学上可接受的 其盐是PGD2受体CRTH2的拮抗剂，因此可用于治疗和/或预防CRTH2-弥漫性疾病如哮喘。

    Indole derivatives as crth2 receptor antagonists
    38.
    发明申请
    Indole derivatives as crth2 receptor antagonists 有权
    吲哚衍生物作为crth2受体拮抗剂

    公开(公告)号：US20090286825A1

    公开(公告)日：2009-11-19

    申请号：US11990378

    申请日：2006-08-07

    申请人： Zhaoyin Wang

    发明人： Zhaoyin Wang

    IPC分类号： A61K31/437 ,  C07D487/04 ,  A61K31/40

    CPC分类号： C07D471/04 ,  C07D487/04

    摘要： Compounds according to formula (I) wherein the radicals R1, R2 and R3 are as herein defined, and wherein Ar represents an aryl group or heteroaryl group, preferably phenyl, n is 1 or 2, and the radical X represents a group selected from —C(Ra)(Rb)—, —C(Ra)(Rb)—C(Ra)(Rb)—, —C(Ra)═C(Ra)—, OC(Ra)(Rb)— or SC(Ra)(Rb)—. These compounds and their pharmaceutical acceptable salts are used in pharmaceutical compositions as prostaglandine D2 receptor antagonists useful in the treatment of CRTH2-mediated diseases such as respiratory, inflammatory or allergic conditions among others.

    摘要翻译： 根据式（I）的化合物，其中基团R 1，R 2和R 3如本文所定义，并且其中Ar表示芳基或杂芳基，优选苯基，n为1或2，基团X表示选自 - C（Ra）（Rb） - ， - （R a）（R b）-C（R a）（R b） - ， - Ra）（Rb） - 。 这些化合物及其药学上可接受的盐在药物组合物中用作可用于治疗CRTH2介导的疾病如呼吸道，炎性或过敏性疾病等的前列腺素D2受体拮抗剂。