公开(公告)号：US20090270403A1

公开(公告)日：2009-10-29

申请号：US12299114

申请日：2007-05-29

申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Daniel B. Timmermann ,  Steven Charles Loechel

发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Daniel B. Timmermann ,  Steven Charles Loechel

IPC分类号： A61K31/4995 ,  C07D403/02 ,  A61P25/28 ,  A61P25/16 ,  A61P25/22 ,  A61P25/18 ,  A61P29/00 ,  A61P3/04 ,  A61P9/12 ,  A61P25/34 ,  A61P25/36 ,  A61P25/32

CPC分类号： C07D471/08

摘要： This invention relates to a novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its use in the manufacture of pharmaceutical compositions. The compound of the invention is found to be a cholinergic ligand at the nicotinic acetylcholine receptors.Due to its pharmacological profile the compound of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

公开(公告)号：US20080280912A1

公开(公告)日：2008-11-13

申请号：US12093655

申请日：2006-12-05

申请人： Dan Peters ,  Daniel B. Timmermann ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring

发明人： Dan Peters ,  Daniel B. Timmermann ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring

IPC分类号： A61K31/4995 ,  C07D471/08 ,  A61P25/28 ,  A61P25/34 ,  A61P25/36 ,  A61P25/16 ,  A61K31/501

CPC分类号： C07D471/08

摘要： This invention relates to novel diazabicyclic aryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

摘要翻译： 本发明涉及新的二氮杂双环芳基衍生物，其被发现是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

公开(公告)号：US20080227773A1

公开(公告)日：2008-09-18

申请号：US10586836

申请日：2005-02-01

申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring Jorgensen ,  Daniel B Timmermann

发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring Jorgensen ,  Daniel B Timmermann

IPC分类号： A61K31/551 ,  C07D243/00 ,  A61P25/02 ,  A61P25/28 ,  A61P25/34 ,  A61P37/02

CPC分类号： C07D471/08

摘要： This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemicals substances.

摘要翻译： 本发明涉及新的二氮杂双环芳基衍生物，其在烟碱乙酰胆碱受体和单胺受体和转运蛋白的调节剂中被发现是胆碱能配体。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

公开(公告)号：US20080153806A1

公开(公告)日：2008-06-26

申请号：US11665387

申请日：2005-10-18

申请人： Dan Peters ,  Daniel B. Timmermann ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring Jorgensen

发明人： Dan Peters ,  Daniel B. Timmermann ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring Jorgensen

IPC分类号： A61K31/55 ,  C07D223/14 ,  A61P25/00 ,  A61P3/00 ,  A61P21/00 ,  A61P5/00 ,  A61P29/00

CPC分类号： C07D487/08

摘要： This invention relates to novel diazabicyclic aryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

摘要翻译： 本发明涉及新的二氮杂双环芳基衍生物，其被发现是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

公开(公告)号：US20110257161A1

公开(公告)日：2011-10-20

申请号：US13132366

申请日：2009-12-03

申请人： Dan Peters ,  Daniel B. Timmermann ,  Elsebet ?stergaard Nielsen ,  Jeppe Kejser Christensen ,  Tino Dyhring

发明人： Dan Peters ,  Daniel B. Timmermann ,  Elsebet ?stergaard Nielsen ,  Jeppe Kejser Christensen ,  Tino Dyhring

IPC分类号： A61K31/551 ,  A61P25/28 ,  A61P25/18 ,  A61P25/24 ,  A61P25/00 ,  A61P3/04 ,  A61P25/16 ,  A61P25/14 ,  A61P25/22 ,  A61P25/08 ,  A61P25/02 ,  A61P9/10 ,  A61P15/06 ,  A61P1/12 ,  A61P11/06 ,  A61P15/10 ,  A61P29/00 ,  A61P17/10 ,  A61P25/30 ,  A61P25/32 ,  A61P25/34 ,  A61P25/36 ,  C07D487/04

CPC分类号： C07D471/08

摘要： This invention relates to novel diazabicyclononyl-phenyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

摘要翻译： 本发明涉及新的二氮杂双环壬基苯基衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

公开(公告)号：US20120238553A1

公开(公告)日：2012-09-20

申请号：US13146103

申请日：2010-01-25

申请人： Dan Peters ,  Daniel B. Timmermann ,  Elsebet Østergaard Nielsen ,  Tino Dyhring ,  Jeppe Kejser Christensen

发明人： Dan Peters ,  Daniel B. Timmermann ,  Elsebet Østergaard Nielsen ,  Tino Dyhring ,  Jeppe Kejser Christensen

IPC分类号： A61K31/551 ,  A61P25/00 ,  A61P25/28 ,  A61P25/24 ,  A61P25/18 ,  A61P3/04 ,  A61P25/16 ,  A61P25/14 ,  A61P25/22 ,  A61P25/08 ,  A61P25/02 ,  A61P25/06 ,  A61P21/00 ,  A61P15/06 ,  A61P1/12 ,  A61P11/06 ,  A61P15/10 ,  A61P9/12 ,  A61P29/00 ,  A61P17/10 ,  A61P1/00 ,  A61P1/04 ,  A61P25/30 ,  A61P25/34 ,  A61P25/36 ,  A61P25/32 ,  C07D471/08

CPC分类号： C07D471/08

摘要： This invention relates to novel benzodioxolyl-oxadiazolyl-diazabicyclononane derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances (I).

摘要翻译： 本发明涉及新的苯并二恶唑 - 恶二唑基 - 二氮杂双环壬烷衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与由化学物质（I）的滥用引起的炎症，疼痛和戒断症状相关的神经变性，疾病或病症相关的疾病或病症。

公开(公告)号：US20120071469A1

公开(公告)日：2012-03-22

申请号：US13319936

申请日：2010-05-12

申请人： Dan Peters ,  Daniel B. Timmermann ,  Elsebet Østergaard Nielsen ,  Jeppe Kejser Christensen ,  Tino Dyhring

发明人： Dan Peters ,  Daniel B. Timmermann ,  Elsebet Østergaard Nielsen ,  Jeppe Kejser Christensen ,  Tino Dyhring

IPC分类号： A61K31/551 ,  A61P25/00 ,  A61P25/28 ,  A61P25/18 ,  A61P25/24 ,  A61P25/22 ,  A61P3/04 ,  A61P25/16 ,  A61P25/08 ,  A61P11/06 ,  A61P9/12 ,  A61P29/00 ,  A61P17/10 ,  A61P1/00 ,  A61P25/30 ,  C07D487/08

CPC分类号： C07D487/08

摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.1]octane derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

摘要翻译： 本发明涉及新的1,4-二氮杂双环[3.2.1]辛烷衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或病症多种多样 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

公开(公告)号：US20120028967A1

公开(公告)日：2012-02-02

申请号：US13145293

申请日：2010-01-20

申请人： Dan Peters ,  Daniel B. Timmermann ,  Elsebet Østergaard Nielsen ,  Tino Dyhring ,  Jeppe Kejser Christensen

发明人： Dan Peters ,  Daniel B. Timmermann ,  Elsebet Østergaard Nielsen ,  Tino Dyhring ,  Jeppe Kejser Christensen

IPC分类号： A61K31/551 ,  A61P25/00 ,  A61P25/28 ,  A61P25/18 ,  A61P25/24 ,  A61P25/22 ,  A61P25/08 ,  A61P25/14 ,  A61P1/00 ,  A61P1/04 ,  A61P11/06 ,  A61P1/12 ,  A61P9/12 ,  A61P25/30 ,  A61P25/34 ,  A61P25/36 ,  A61P25/32 ,  C07D487/08

CPC分类号： C07D471/08

摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

摘要翻译： 本发明涉及新的1,4-二氮杂 - 双环[3.2.2]壬基嘧啶衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

公开(公告)号：US20120028968A1

公开(公告)日：2012-02-02

申请号：US13146240

申请日：2010-01-25

申请人： Dan Peters ,  Daniel B. Timmermann ,  Elsebet Østergaard Nielsen ,  Jeppe Kejser Christensen ,  Tino Dyhring

发明人： Dan Peters ,  Daniel B. Timmermann ,  Elsebet Østergaard Nielsen ,  Jeppe Kejser Christensen ,  Tino Dyhring

IPC分类号： A61K31/551 ,  A61P25/00 ,  A61P25/28 ,  A61P25/18 ,  A61P25/24 ,  A61P25/16 ,  A61P25/14 ,  A61P29/00 ,  A61P17/00 ,  A61P25/30 ,  A61P1/00 ,  A61P1/04 ,  A61P1/12 ,  A61P17/10 ,  C07D487/08

CPC分类号： C07D471/08

摘要： This invention relates to novel dibenzofuranyl-oxadiazolyl-diazabicyclononane derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

摘要翻译： 本发明涉及新的二苯并呋喃基 - 恶二唑基 - 二氮杂双环壬烷衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

公开(公告)号：US20120003153A1

公开(公告)日：2012-01-05

申请号：US13145979

申请日：2010-01-25

申请人： Dan Peters ,  Daniel B. Timmermann ,  Tino Dyhring ,  Jeppe Kejser Christensen ,  Elsebet Østergaard Nielsen

发明人： Dan Peters ,  Daniel B. Timmermann ,  Tino Dyhring ,  Jeppe Kejser Christensen ,  Elsebet Østergaard Nielsen

IPC分类号： A61K51/04 ,  A61K31/551 ,  A61K49/00 ,  A61P25/00 ,  A61P25/28 ,  A61P25/24 ,  A61P25/18 ,  A61P3/04 ,  A61P25/20 ,  A61P25/16 ,  A61P25/08 ,  A61P25/22 ,  A61P25/14 ,  A61P25/04 ,  A61P25/06 ,  A61P29/00 ,  A61P15/00 ,  A61P15/06 ,  A61P43/00 ,  A61P1/12 ,  A61P11/16 ,  A61P9/12 ,  A61P17/00 ,  A61P17/10 ,  A61P1/00 ,  A61P25/30 ,  A61P25/32 ,  A61P25/34 ,  A61P25/36 ,  C07D471/08

CPC分类号： C07D413/14 ,  A61K51/0468 ,  C07D471/08

摘要： This invention relates to novel indolyl-oxadiazolyl-diazabicyclononane derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

摘要翻译： 本发明涉及新的吲哚基 - 恶二唑基 - 二氮杂双环壬烷衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。