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128 条记录 (耗时 0.03 秒)

    1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its medical use
    31.
    发明授权
    1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its medical use 失效
    1,4-二氮杂 - 双环[3.2.2]壬基嘧啶基衍生物及其医疗用途

    公开(公告)号：US07915272B2

    公开(公告)日：2011-03-29

    申请号：US12299114

    申请日：2007-05-29

    申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Daniel B Timmermann ,  Steven Charles Loechel

    发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Daniel B Timmermann ,  Steven Charles Loechel

    IPC分类号： A61K31/505

    CPC分类号： C07D471/08

    摘要： This invention relates to a novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its use in the manufacture of pharmaceutical compositions. The compound of the invention is found to be a cholinergic ligand at the nicotinic acetylcholine receptors.Due to its pharmacological profile the compound of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的1,4-二氮杂双环[3.2.2]壬基嘧啶基衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或病症多种多样 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Azacyclic ethynyl derivatives
    33.
    发明授权
    Azacyclic ethynyl derivatives 失效
    偶氮乙炔衍生物

    公开(公告)号：US07378526B2

    公开(公告)日：2008-05-27

    申请号：US10513416

    申请日：2003-05-06

    申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Tino Dyhring Jørgensen ,  Philip K. Ahring

    发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Tino Dyhring Jørgensen ,  Philip K. Ahring

    IPC分类号： C07D401/00 ,  C07D451/02 ,  C07D405/00

    CPC分类号： C07D451/02 ,  C07D211/70 ,  C07D453/02

    摘要： This invention relates to novel azacyclic ethynyl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新颖的氮杂环乙炔衍生物，其被发现是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its medical use
    37.
    发明授权
    1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its medical use 失效
    1,4-二氮杂 - 双环[3.2.2]壬基嘧啶基衍生物及其医疗用途

    公开(公告)号：US08148365B2

    公开(公告)日：2012-04-03

    申请号：US12299106

    申请日：2007-05-29

    申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Daniel B Timmermann ,  Steven Charles Loechel

    发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Daniel B Timmermann ,  Steven Charles Loechel

    IPC分类号： A61K31/55 ,  C07D223/14

    CPC分类号： C07D471/08

    摘要： This invention relates to a novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivative and its use in the manufacture of pharmaceutical compositions. The compound of the invention is found to be a cholinergic ligand at the nicotinic acetylcholine receptors.Due to its pharmacological profile the compound of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的1,4-二氮杂双环[3.2.2]壬基嘧啶基衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或病症多种多样 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use
    38.
    发明授权
    1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use 有权
    1,4-二氮杂双环[3.2.2]壬基恶二唑基衍生物及其医疗用途

    公开(公告)号：US08101598B2

    公开(公告)日：2012-01-24

    申请号：US12861420

    申请日：2010-08-23

    申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Daniel B. Timmermann ,  Steven Charles Loechel

    发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Daniel B. Timmermann ,  Steven Charles Loechel

    IPC分类号： A61P25/00 ,  A61K31/551 ,  C07D471/08

    CPC分类号： C07D471/08

    摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的1,4-二氮杂 - 双环[3.2.2]壬基恶二唑基衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。