公开(公告)号：US20200261222A1

公开(公告)日：2020-08-20

申请号：US16861171

申请日：2020-04-28

申请人： Edwards Lifesciences Corporation

发明人： Bin Tian ,  James A. Davidson

IPC分类号： A61F2/24 ,  A01N1/02 ,  A61L27/36 ,  A61L27/50

摘要： A method of treating a biological tissue that enables dry storage of said tissue is disclosed. In one embodiment, the method comprises contacting the biological tissue with a non-aqueous treatment solution comprising a polyhydric alcohol and a C1-C3 alcohol and removing a portion of the treatment solution from the solution-treated biological tissue. Also disclosed is biological tissue prepared using the above process and prosthetic devices made with such tissue.

公开(公告)号：US20190038403A1

公开(公告)日：2019-02-07

申请号：US16154353

申请日：2018-10-08

申请人： Edwards Lifesciences Corporation

发明人： Jeffrey S. Dove ,  Bin Tian ,  Ralph Schneider ,  Jeffrey S. Cohen ,  Ivan Jankovic ,  John F. Migliazza ,  Gregory A. Wright ,  James M. Young ,  Louis A. Campbell

IPC分类号： A61F2/24 ,  B65B63/02 ,  A61B18/20 ,  B65B55/18 ,  A61L27/36 ,  A61L27/50 ,  A61F2/02 ,  A61F2/30

摘要： Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes.