公开(公告)号：US11446502B2

公开(公告)日：2022-09-20

申请号：US16955264

申请日：2018-12-20

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： Matteo Donega ,  Daniel John Chew ,  Isha Gupta

IPC: A61N1/36 ,  A61N1/05

Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is associated with a neurovascular bundle, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating inflammatory disorders. The invention provides improved ways of treating inflammatory disorders which minimize off-target effects.

公开(公告)号：US20220080208A1

公开(公告)日：2022-03-17

申请号：US17415599

申请日：2019-12-13

Applicant: Galvani Bioelectronics Limited

Inventor： David Karl Lee Peterson ,  Daniel John Chew ,  Matteo Donega ,  Xu Meng

IPC: A61N1/36 ,  A61N1/05

Abstract: A system (1) for electrically stimulating a nerve (3), the system comprising: a first stimulator (5) and a second stimulator (7) for electrically stimulating the nerve, the first stimulator and the second stimulator spaced apart from one another by a first distance; and a controller (9) arranged to: a) set a time interval as a function of the first distance and the speed of propagation of an action potential in the nerve; b) activate the first stimulator for a first stimulation period, thus inducing electrical activity in the nerve; and c) activate the second stimulator for a second stimulation period after the time interval has elapsed after the end of the first time period. Preferably, the time interval is a sum of the first time period and a buffer time period for allowing the nerve to recover from stimulation.