公开(公告)号：US5670171A

公开(公告)日：1997-09-23

申请号：US482092

申请日：1995-06-07

申请人： Giancarlo Santus ,  Giuseppe Bottoni ,  Ettore Bilato

发明人： Giancarlo Santus ,  Giuseppe Bottoni ,  Ettore Bilato

IPC分类号： A61K9/00 ,  A61K9/50 ,  A61K9/52 ,  A61K31/19 ,  A61K31/192 ,  A61K9/16

CPC分类号： A61K9/0095 ,  A61K31/19 ,  A61K31/192 ,  A61K9/5073

摘要： Disclosed is a liquid-suspension controlled-release enteric-coated pharmaceutical formulation for the administration of naproxen, comprising (a) microgranules of naproxen and an excipient; (b) four successive coats of polymeric hydrophilic and hydrophobic materials, at least the innermost of said coats imparting controlled-release properties to said naproxen according to a predetermined release profile, and at least the outermost of said coats imparting resistance to dissolution in gastric fluids; and (c) a liquid administration vehicle. This composition enables the oral administration of naproxen as a single daily dose the adjustment of the dosage to a patient's requirements, and avoids detrimental effects of prolonged contact of naproxen with the gastric mucosa thus aiding oral intake and minimizing the drug's typical side effects.

摘要翻译： 公开了一种用于施用萘普生的液体 - 悬液控释肠溶衣制剂，其包含（a）萘普生微粒和赋形剂; （b）四个连续的聚合亲水和疏水材料的涂层，至少最内层的所述涂层根据预定的释放曲线赋予所述萘普生的控制释放性能，并且至少所述涂层的最外面赋予对胃液中溶解的抵抗力 ; 和（c）液体给药载体。 该组合物能够以单次日剂量口服给予萘普生，根据患者的要求调整剂量，并避免萘普生与胃粘膜长时间接触的有害作用，从而有助于口服摄取，并使药物的典型副作用最小化。

公开(公告)号：US5405619A

公开(公告)日：1995-04-11

申请号：US191013

申请日：1994-02-01

申请人： Giancarlo Santus ,  Roberto Golzi

发明人： Giancarlo Santus ,  Roberto Golzi

IPC分类号： A61K9/00 ,  A61K9/50 ,  A61K31/192 ,  A61K9/16

CPC分类号： A61K9/0095 ,  A61K31/192 ,  A61K9/5073

摘要： Disclosed is a controlled release pharmaceutical dosage form, including: (a) microgranules of a pharmaceutical and an excipient; (b) a plurality of polymeric lipidic and wax-like coatings applied to the microgranules, the coated microgranules having dimensions which allow suspension of the coated microgranules in a liquid administration vehicle; and (c) a liquid administration vehicle for the coated microgranules, the vehicle including an effective amount of the pharmaceutical in a form immediately available upon ingestion. A process for the preparation of the controlled release therapeutic system is also described.

摘要翻译： 公开了一种控释药物剂型，其包括：（a）药物和赋形剂的微粒; （b）施用于微粒的多个聚合脂质和蜡状涂层，所述涂覆的微粒具有允许将涂覆的微粒悬浮在液体给药载体中的尺寸; 和（c）用于涂覆的微粒的液体给药载体，所述载体包含在摄取后立即可获得的形式的有效量的药物。 还描述了用于制备控制释放治疗系统的方法。