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公开(公告)号：US20210040319A1
公开(公告)日：2021-02-11
申请号：US16531432
申请日：2019-08-05
发明人： Nathaniel H. Park , James L. Hedrick , Victoria A. Piunova , Gavin Jones , Yi Yan Yang , Pang Kern Jeremy Tan , Chuan Yang , Cherylette Anne Alexander
IPC分类号： C08L79/02
摘要： Techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided. For example, one or more embodiments described herein can comprise a chemical composition, which can comprise a polymer comprising a molecular backbone covalently bonded to a pendent guanidinium functional group, wherein the molecular backbone can comprise a polylysine structure.
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公开(公告)号：US20210040265A1
公开(公告)日：2021-02-11
申请号：US17072771
申请日：2020-10-16
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Chuan Yang , Yi Yan Yang
IPC分类号： C08G73/02 , A61P31/06 , A61K31/787 , A61K31/166 , C07C13/47
摘要： Techniques regarding killing of a pathogen with one or more ionene compositions having antimicrobial functionality are provided. For example, one or more embodiments can comprise a method, which can comprise contacting a Mycobacterium tuberculosis microbe with a chemical compound. The chemical compound can comprise an ionene unit. Also, the ionene unit can comprise a cation distributed along a molecular backbone. The ionene unit can have antimicrobial functionality. The method can further comprise electrostatically disrupting a membrane of the Mycobacterium tuberculosis microbe in response to the contacting.
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公开(公告)号：US20200221695A1
公开(公告)日：2020-07-16
申请号：US16829370
申请日：2020-03-25
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Chuan Yang , Yi Yan Yang
摘要： Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality.
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公开(公告)号：US10687528B2
公开(公告)日：2020-06-23
申请号：US15839397
申请日：2017-12-12
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Chuan Yang , Yi Yan Yang
IPC分类号： A01N25/04 , A01N27/00 , A01N33/04 , A01N43/08 , A01N37/02 , A01N37/20 , A01N47/12 , A01N33/12 , A61K8/84 , A61Q17/00
摘要： Techniques regarding ionene and/or polyionene compositions with antimicrobial functionalities are provided. For example, one or more embodiments can comprise a chemical compound, which can comprise an ionene unit. The ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a norspermidine structure having a carbonyl group. Also, the ionene unit can have antimicrobial functionality.
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公开(公告)号：US20190174756A1
公开(公告)日：2019-06-13
申请号：US15839270
申请日：2017-12-12
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Chuan Yang , Yi Yan Yang
摘要： Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality.
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公开(公告)号：US20190161562A1
公开(公告)日：2019-05-30
申请号：US15824153
申请日：2017-11-28
IPC分类号： C08F8/42 , A01N55/02 , C09D5/14 , C09D153/00
摘要： Techniques regarding a star polymer with light-activated enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a plurality of non-degradable copolymer arms comprising respective first ends and respective second ends. The respective first ends can be crosslinked to form a vinyl polymer core and the respective second ends can have antimicrobial functionality. Further, the polymer can comprise a singlet oxygen generator loaded within the vinyl polymer core. The singlet oxygen generator can generate a singlet oxygen species in response to light.
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公开(公告)号：US11525036B2
公开(公告)日：2022-12-13
申请号：US17072771
申请日：2020-10-16
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Chuan Yang , Yi Yan Yang
IPC分类号： A61K31/66 , A61K31/787 , A61P31/06 , C08G73/02 , A61K31/166 , C07C13/47
摘要： Techniques regarding killing of a pathogen with one or more ionene compositions having antimicrobial functionality are provided. For example, one or more embodiments can comprise a method, which can comprise contacting a Mycobacterium tuberculosis microbe with a chemical compound. The chemical compound can comprise an ionene unit. Also, the ionene unit can comprise a cation distributed along a molecular backbone. The ionene unit can have antimicrobial functionality. The method can further comprise electrostatically disrupting a membrane of the Mycobacterium tuberculosis microbe in response to the contacting.
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公开(公告)号：US11520310B2
公开(公告)日：2022-12-06
申请号：US16444565
申请日：2019-06-18
发明人： Dmitry Zubarev , Victoria A. Piunova , Nathaniel H. Park , James L. Hedrick , Sarath Swaminathan
IPC分类号： G05B19/4155 , G06N20/00 , G05B13/02
摘要： Techniques regarding autonomously controlling one or more chemical reactors using generative machine learning models are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a memory that can store computer executable components. The system can also comprise a processor, operably coupled to the memory, and that can execute the computer executable components stored in the memory. The computer executable components can comprise a model component that can build a generative machine learning model based on training data regarding a past chemical reactor operation. The generative machine learning model can generate a recommended chemical reactor control setting for experimental discovery of a polymer.
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公开(公告)号：US20210212314A1
公开(公告)日：2021-07-15
申请号：US17215700
申请日：2021-03-29
发明人： James L. Hedrick , Mareva B. Fevre , Nathaniel H. Park , Victoria A. Piunova , Yi Yan Yang , Pang Kern Jeremy Tan
IPC分类号： A01N25/10 , A01N43/50 , A01N37/26 , C07C279/10 , C08L79/02 , C08G69/26 , C08G73/02 , A01N47/44 , C08L101/00
摘要： Techniques regarding chemical compounds with antimicrobial functionality are provided. For example, one or more embodiments describe herein can comprise a monomer that can comprise a molecular backbone. The molecular backbone can comprise a bis(urea)guanidinium structure covalently bonded to a functional group, which can comprise a radical. Also, the monomer can have supramolecular assembly functionality.
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公开(公告)号：US11058110B2
公开(公告)日：2021-07-13
申请号：US16829370
申请日：2020-03-25
发明人： Mareva B. Fevre , James L. Hedrick , Nathaniel H. Park , Victoria A. Piunova , Pang Kern Jeremy Tan , Chuan Yang , Yi Yan Yang
摘要： Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality.
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