公开(公告)号：US20060263850A1

公开(公告)日：2006-11-23

申请号：US11458360

申请日：2006-07-18

申请人： Donald Foster ,  Wenfeng Xu ,  Karen Madden ,  James Kelly ,  Cindy Sprecher ,  Cameron Brandt ,  Mark Rixon ,  Scott Presnell ,  Brian Fox

发明人： Donald Foster ,  Wenfeng Xu ,  Karen Madden ,  James Kelly ,  Cindy Sprecher ,  Cameron Brandt ,  Mark Rixon ,  Scott Presnell ,  Brian Fox

IPC分类号： C07K14/715 ,  C12P21/06

CPC分类号： C07K16/2866 ,  A61K38/00 ,  C07K14/7155 ,  C07K2319/00

摘要： A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.

公开(公告)号：US20060263851A1

公开(公告)日：2006-11-23

申请号：US11458367

申请日：2006-07-18

申请人： Donald Foster ,  Wenfeng Xu ,  Karen Madden ,  James Kelly ,  Cindy Sprecher ,  Cameron Brandt ,  Mark Rixon ,  Scott Presnell ,  Brian Fox

发明人： Donald Foster ,  Wenfeng Xu ,  Karen Madden ,  James Kelly ,  Cindy Sprecher ,  Cameron Brandt ,  Mark Rixon ,  Scott Presnell ,  Brian Fox

IPC分类号： C12P21/06 ,  C07K14/715

CPC分类号： C07K16/2866 ,  A61K38/00 ,  C07K14/7155 ,  C07K2319/00

摘要： A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.

公开(公告)号：US20050003475A1

公开(公告)日：2005-01-06

申请号：US09745792

申请日：2000-12-22

申请人： Donald Foster ,  Wenfeng Xu ,  Karen Madden ,  James Kelly ,  Cindy Sprecher ,  Cameron Brandt ,  Mark Rixon ,  Scott Presnell ,  Brian Fox

发明人： Donald Foster ,  Wenfeng Xu ,  Karen Madden ,  James Kelly ,  Cindy Sprecher ,  Cameron Brandt ,  Mark Rixon ,  Scott Presnell ,  Brian Fox

IPC分类号： A61K38/00 ,  C07K14/715 ,  A61K38/17 ,  C07H21/04

CPC分类号： C07K16/2866 ,  A61K38/00 ,  C07K14/7155 ,  C07K2319/00

摘要： A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.

摘要翻译： 具有两个多肽亚单位IL-20RA（以前称为ZcytoR7）和IL-20RB（以前称为DIRS1）的IL-20的可溶性受体。 两个亚基优选连接在一起。 在一个实施方案中，一个亚基与免疫球蛋白的轻链的恒定区融合，另一个亚基与免疫球蛋白的重链的恒定区融合。 轻链和重链通过二硫键连接。

公开(公告)号：US20070048303A1

公开(公告)日：2007-03-01

申请号：US11552243

申请日：2006-10-24

申请人： Cindy Sprecher ,  Scott Presnell ,  Zeren Gao ,  Theodore Whitmore ,  Joseph Kuijper ,  Mark Maurer

发明人： Cindy Sprecher ,  Scott Presnell ,  Zeren Gao ,  Theodore Whitmore ,  Joseph Kuijper ,  Mark Maurer

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： C07K14/715

摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

公开(公告)号：US20070141051A1

公开(公告)日：2007-06-21

申请号：US11552238

申请日：2006-10-24

申请人： Cindy Sprecher ,  Scott Presnell ,  Zeren Gao ,  Theodore Whitmore ,  Joseph Kuijper ,  Mark Maurer

发明人： Cindy Sprecher ,  Scott Presnell ,  Zeren Gao ,  Theodore Whitmore ,  Joseph Kuijper ,  Mark Maurer

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： C07K14/715

摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

公开(公告)号：US20050214801A1

公开(公告)日：2005-09-29

申请号：US10982555

申请日：2004-11-05

申请人： Cindy Sprecher ,  Scott Presnell ,  Zeren Gao ,  Theodore Whitmore ,  Joseph Kuijper ,  Mark Maurer

发明人： Cindy Sprecher ,  Scott Presnell ,  Zeren Gao ,  Theodore Whitmore ,  Joseph Kuijper ,  Mark Maurer

IPC分类号： C07K14/715 ,  C12Q1/68 ,  C07H21/04 ,  C12N15/09

CPC分类号： C07K14/715

摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zcytor17，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor17的多核苷酸位于染色体5上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。

公开(公告)号：US20070049528A1

公开(公告)日：2007-03-01

申请号：US11551337

申请日：2006-10-20

申请人： Cindy Sprecher ,  Scott Presnell ,  Zeren Gao ,  Theodore Whitmore ,  Joseph Kuijper ,  Mark Maurer

发明人： Cindy Sprecher ,  Scott Presnell ,  Zeren Gao ,  Theodore Whitmore ,  Joseph Kuijper ,  Mark Maurer

IPC分类号： A61K38/17 ,  C07K14/715

CPC分类号： C07K14/715

摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

公开(公告)号：US20070049527A1

公开(公告)日：2007-03-01

申请号：US11551328

申请日：2006-10-20

申请人： Cindy Sprecher ,  Scott Presnell ,  Zeren Gao ,  Theodore Whitmore ,  Joseph Kuijper ,  Mark Maurer

发明人： Cindy Sprecher ,  Scott Presnell ,  Zeren Gao ,  Theodore Whitmore ,  Joseph Kuijper ,  Mark Maurer

IPC分类号： A61K38/17 ,  C07K14/715 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K14/715

摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zcytor17，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor17的多核苷酸位于染色体5上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。

公开(公告)号：US20070105777A1

公开(公告)日：2007-05-10

申请号：US11620994

申请日：2007-01-08

申请人： Cindy Sprecher ,  Scott Presnell ,  Zeren Gao ,  Theodore Whitmore ,  Joseph Kuijper ,  Mark Maurer

发明人： Cindy Sprecher ,  Scott Presnell ,  Zeren Gao ,  Theodore Whitmore ,  Joseph Kuijper ,  Mark Maurer

IPC分类号： A61K38/17 ,  C07K14/715 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K14/715

摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytorl7, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zcytor17，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor17的多核苷酸位于染色体5上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。

公开(公告)号：US20070048309A1

公开(公告)日：2007-03-01

申请号：US11551347

申请日：2006-10-20

申请人： Cindy Sprecher ,  Scott Presnell ,  Zeren Gao ,  Theodore Whitmore ,  Joseph Kuijper ,  Mark Maurer

发明人： Cindy Sprecher ,  Scott Presnell ,  Zeren Gao ,  Theodore Whitmore ,  Joseph Kuijper ,  Mark Maurer

IPC分类号： A61K38/17 ,  C07K14/715 ,  C07H21/04 ,  C12P21/06 ,  A61K39/395

CPC分类号： C07K14/715

摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor17, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.