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55 条记录 (耗时 0.042 秒)

    Use of inositol-tripyrophosphate in treating tumors and diseases
    31.
    发明申请
    Use of inositol-tripyrophosphate in treating tumors and diseases 审中-公开
    使用肌醇三磷酸治疗肿瘤和疾病

    公开(公告)号：US20060106000A1

    公开(公告)日：2006-05-18

    申请号：US11175979

    申请日：2005-07-06

    申请人： Claude Nicolau ,  Ruth Greferath ,  Konstantina Fylaktakidou ,  Jean-Marie Lehn

    发明人： Claude Nicolau ,  Ruth Greferath ,  Konstantina Fylaktakidou ,  Jean-Marie Lehn

    IPC分类号： A61K31/66

    CPC分类号： A61K31/66

    摘要： Inositol-tripyrophosphate is an allosteric effector of hemoglobin due to its ability to cross the plasma membrane of red blood cells and deliver oxygen to solid tumors, by lowering the oxygen affinity of the hemoglobin of red blood cells. The present invention is directed to the use of inositol-tripyrophosphate to reduce hemoglobin's affinity for oxygen in circulating red blood cells. The present invention is further directed to the use of inositol-tripyrophosphate to inhibit angiogenesis and enhance radiation sensitivity of hypoxic tumors. The present invention is further directed to the use of inositol-tripyrophosphate to enhance PO2 in hypoxic tumors.

    摘要翻译： 肌醇三磷酸盐是血红蛋白的变构效应物，因为它能够通过降低红细胞血红蛋白的氧亲合力而穿过红细胞的质膜并将氧传递给实体瘤。 本发明涉及肌醇三磷酸降低血红蛋白在循环红细胞中对氧的亲和力的用途。 本发明还涉及肌醇三磷酸盐抑制血管发生和增强缺氧性肿瘤的放射敏感性的用途。 本发明还涉及肌醇三磷酸盐在缺氧性肿瘤中增强PO 2 N 2的用途。

    Rare earth cryptates, processes for their preparation, synthesis intermediates and application as fluorescent tracers
    33.
    发明授权
    Rare earth cryptates, processes for their preparation, synthesis intermediates and application as fluorescent tracers 失效
    稀土穴位，其制备方法，合成中间体和作为荧光示踪剂的应用

    公开(公告)号：US5457185A

    公开(公告)日：1995-10-10

    申请号：US257072

    申请日：1994-06-09

    申请人： Jean-Marie Lehn ,  Geatrice Mathis ,  Beatrice Alpha ,  Robert Deschenaux ,  Etienne Jolu

    发明人： Jean-Marie Lehn ,  Geatrice Mathis ,  Beatrice Alpha ,  Robert Deschenaux ,  Etienne Jolu

    IPC分类号： C07D471/22 ,  C07D498/22 ,  G01N33/533 ,  C07F5/00

    CPC分类号： C07D471/22 ,  G01N33/533 ,  G01N2458/40 ,  Y10S436/80

    摘要： The invention relates to rare earth cryptates consisting of at least one rare earth salt complexed by a macropolycyclic compound corresponding to one of formulae I or II below, in which:the ring ##STR1## is the N.sub.2 O.sub.4 macrocycle, the N.sub.2 O.sub.3 macrocycle or the bis-bipyridine macrocycle;Y is a spacer arm or group which consists of a divalent organic radical selected from linear or branched C.sub.1 to C.sub.20 alkylene groups optionally containing one or more double bonds and/or optionally being interrupted by one or more heteroatoms such as oxygen, nitrogen, sulfur or phosphorus, or from C.sub.5 to C.sub.8 cycloalkylene groups or C.sub.6 to C.sub.14 arylene groups, the said alkylene or arylene groups optionally being substituted by alkyl, aryl or sulfonate groups;Z is a functional group capable of bonding covalently with a biological substance;R is a methyl group or represents the group --Y--Z; andR' is hydrogen or a group --COOR", in which R" is a C.sub.1 to C.sub.10 alkyl group and preferably represents the methyl, ethyl or tert.-butyl group, or alternatively R' is a group --CO--NH--Y--Z. ##STR2##

    摘要翻译： 本发明涉及由至少一种由相应于下式I或II之一的大环化合物络合的稀土盐组成的稀土穴状化合物，其中：环是N 2 O 4大环，N 2 O 3大环或双 - 联吡啶大环 Y是间隔子臂或基团，其由选自直链或支链C1至C20亚烷基的二价有机基团组成，任选地含有一个或多个双键和/或任选被一个或多个杂原子例如氧，氮，硫或 磷，或从C5至C8亚环烷基或C6至C14亚芳基，所述亚烷基或亚芳基任选被烷基，芳基或磺酸酯基取代; Z是能够与生物物质共价键合的官能团; R是甲基或代表基团-Y-Z; 并且R'是氢或-COOR“基团，其中R”是C1至C10烷基，并且优选代表甲基，乙基或叔丁基，或者R'是基团-CO-NH -YZ。 II。图像II

    Monocyclic macrocyclic compounds and complexes thereof
    35.
    发明授权
    Monocyclic macrocyclic compounds and complexes thereof 失效
    单环大环化合物及其络合物

    公开(公告)号：US3966766A

    公开(公告)日：1976-06-29

    申请号：US560281

    申请日：1975-03-20

    申请人： Jean-Marie Lehn

    发明人： Jean-Marie Lehn

    IPC分类号： C07C51/27 ,  C07C59/125 ,  C07C59/135 ,  C07C59/68 ,  C07C323/25 ,  C07D209/48 ,  C07D273/00 ,  C07F9/50 ,  C07F9/54

    CPC分类号： C07D209/48 ,  C07C323/25 ,  C07C51/27 ,  C07C59/125 ,  C07C59/135 ,  C07C59/68 ,  C07D273/00 ,  C07F9/5027 ,  C07F9/5449

    摘要： Novel monocyclic macrocyclic compounds having nitrogen bridgehead atoms and having in the hydrocarbon bridging chains at least two additional hetero atoms selected from the group consisting of sulfur, oxygen, and nitrogen, when admixed with a compatible cation-donor compound form stable cation-containing macrocyclic complexes which, in turn, can be conveniently dissociated by addition of acid or a quaternizing agent. The novel macrocyclics are valuable for use in the same way and for the same purposes as chelating agents.

    摘要翻译： 具有氮桥头原子的新型单环大环化合物并且在烃桥连中具有选自硫，氧和氮的至少两个另外的杂原子，当与相容的阳离子供体化合物混合时形成稳定的含阳离子的大环络合物 这又可以通过加入酸或季铵化剂方便地解离。 新颖的大环境用于以与螯合剂相同的方式和相同的目的使用。

    USE OF INOSITOL-TRIPYROPHOSPHATE IN TREATING TUMORS AND DISEASES
    36.
    发明申请
    USE OF INOSITOL-TRIPYROPHOSPHATE IN TREATING TUMORS AND DISEASES 审中-公开
    在治疗肿瘤和疾病中使用非甾体 - 磷酸二氢钙

    公开(公告)号：US20120035137A1

    公开(公告)日：2012-02-09

    申请号：US13168728

    申请日：2011-06-24

    申请人： Konstantina C. Fylaktakidou ,  Jean-Marie Lehn ,  Claude Nicolau ,  Ruth Greferath

    发明人： Konstantina C. Fylaktakidou ,  Jean-Marie Lehn ,  Claude Nicolau ,  Ruth Greferath

    IPC分类号： A61K31/6615 ,  A61P35/02 ,  A61P35/04

    CPC分类号： A61K31/66 ,  C07F9/65746

    摘要： Inositol-tripyrophosphate is an allosteric effector of hemoglobin due to its ability to cross the plasma membrane of red blood cells and deliver oxygen to solid tumors, by lowering the oxygen affinity of the hemoglobin of red blood cells. The present invention is directed to the use of inositol-tripyrophosphate to reduce hemoglobin's affinity for oxygen in circulating red blood cells. The present invention is further directed to the use of inositol-tripyrophosphate to inhibit angiogenesis and enhance radiation sensitivity of hypoxic tumors. The present invention is further directed to the use of inositol-tripyrophosphate for the treatment of various types of cancers, Alzheimer's disease, stroke and osteoporosis.

    摘要翻译： 肌醇三磷酸盐是血红蛋白的变构效应物，因为它能够通过降低红细胞血红蛋白的氧亲合力而穿过红细胞的质膜并将氧传递给实体瘤。 本发明涉及肌醇三磷酸降低血红蛋白在循环红细胞中对氧的亲和力的用途。 本发明还涉及肌醇三磷酸盐抑制血管发生和增强缺氧性肿瘤的放射敏感性的用途。 本发明还涉及肌醇三磷酸盐用于治疗各种类型的癌症，阿尔茨海默氏病，中风和骨质疏松症的用途。

    CONTROLLED RELEASE OF ACTIVE COMPOUNDS FROM DYNAMIC MIXTURES
    38.
    发明申请
    CONTROLLED RELEASE OF ACTIVE COMPOUNDS FROM DYNAMIC MIXTURES 审中-公开
    从动态混合物控制活性化合物的释放

    公开(公告)号：US20100226875A1

    公开(公告)日：2010-09-09

    申请号：US12161780

    申请日：2007-01-19

    申请人： Andreas Herrmann ,  Jean-Marie Lehn ,  Guillaume Godin

    发明人： Andreas Herrmann ,  Jean-Marie Lehn ,  Guillaume Godin

    IPC分类号： A61K8/33 ,  A61Q13/00 ,  A01N35/00 ,  A23L1/221 ,  A61K8/35

    CPC分类号： A61Q13/00 ,  A01N25/18 ,  A61K8/40 ,  A61K8/41 ,  A61K2800/57 ,  A61Q17/02 ,  C11D3/507 ,  A01N35/02 ,  A01N35/04

    摘要： The present invention relates to a dynamic mixture in the form of a dynamic mixture obtained by reacting together, in the presence of water, at least one O-substituted hydroxylamine or S-substituted thiohydroxylamine derivative with at least one perfuming, flavoring, insect repellent or attractant, bactericide or fungicide aldehyde or ketone. This mixture is capable of releasing in a controlled and prolonged manner the aldehyde or ketone into the surrounding environment. Furthermore, the present invention concerns also the use of these dynamic mixtures as perfuming ingredients as well as the perfuming compositions or perfumed articles that include these mixtures.

    摘要翻译： 本发明涉及以动态混合物形式的动态混合物，其通过在水存在下使至少一种O-取代的羟胺或S-取代的硫羟基胺衍生物与至少一种加香，调味剂，驱虫剂或 引诱剂，杀菌剂或杀真菌剂醛或酮。 该混合物能够以受控和长时间的方式将醛或酮释放到周围环境中。 此外，本发明还涉及这些动态混合物作为加香成分以及包含这些混合物的加香组合物或香料制品的用途。

    Erythropoietin complementation or replacement
    40.
    发明申请
    Erythropoietin complementation or replacement 审中-公开
    红细胞生成素互补或替代

    公开(公告)号：US20080312138A1

    公开(公告)日：2008-12-18

    申请号：US12150946

    申请日：2008-05-01

    申请人： Claude Nicolau ,  Jean-Marie Lehn ,  Ruth Greferath

    发明人： Claude Nicolau ,  Jean-Marie Lehn ,  Ruth Greferath

    IPC分类号： A61K38/22 ,  A61K31/7042 ,  A61P7/06 ,  A61P7/00

    CPC分类号： A61K31/66 ,  A61K31/6615 ,  A61K35/15 ,  A61K38/1816 ,  A61K2300/00

    摘要： The present invention provides methods and compositions to replace up to 90% of erythropoietin use in the treatment of anemias and hypoxias. The method employs acid and salt forms of inositol-tripyrophosphate (ITPP) isomers to shift the P50 value of hemoglobin, thereby improving the rate and efficiency of oxygenation by blood even when red blood cell counts are low. Indications for the new method include anemias and hypoxia arising from infection, chemotherapy, premature birth, altitude change, compromised lung or heart function, aplastic anemia and anemia associated with a myelodysplastic syndrome, and other causes.

    摘要翻译： 本发明提供了用于替代高达90％的红细胞生成素用于治疗贫血和缺氧的方法和组合物。 该方法采用酸性和盐形式的肌醇三磷酸（ITPP）异构体来移动血红蛋白的P50值，从而即使红细胞计数低，也能提高血液氧合的速率和效率。 新方法的适应症包括感染，化疗，早产，高原变化，肺或心脏功能受损，再生障碍性贫血和与骨髓增生异常综合征相关的贫血引起的贫血和缺氧以及其他原因。