-
公开(公告)号:US5622989A
公开(公告)日:1997-04-22
申请号:US449402
申请日:1995-05-23
申请人: Gabriele Br aunlich , R udiger Fischer , Mazen Es-Sayed , Rudolf Hanko , Stephen Tudhope , Graham Sturton , Trevor Abram , Wendy J. McDonald-Gibson , Mary F. Fitzgerald
发明人: Gabriele Br aunlich , R udiger Fischer , Mazen Es-Sayed , Rudolf Hanko , Stephen Tudhope , Graham Sturton , Trevor Abram , Wendy J. McDonald-Gibson , Mary F. Fitzgerald
IPC分类号: C07D333/56 , A61K31/34 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/4025 , A61K31/42 , A61K31/44 , A61K31/443 , A61K31/4433 , A61P1/00 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/08 , A61P29/00 , A61P43/00 , C07D307/80 , C07D307/83 , C07D307/84 , C07D333/60 , C07D405/06 , C07D405/10 , C07D405/12 , C07D409/10 , C07D409/12 , C07D413/12
CPC分类号: C07D405/06 , C07D307/80 , C07D307/83 , C07D307/84 , C07D405/10 , C07D405/12 , C07D409/10 , C07D409/12 , C07D413/12
摘要: 6-Amino-benzofuryl- and thienyl-derivatives can be prepared by reacting appropriate amino-substituted benzoyl phenols with appropriate substituted acetophenones and subsequent modification of the substituents. The compounds are useful for the treatment of actual and chronic inflammatory diseases, particularly of the airways and the gastro-intestinal tract.
摘要翻译: 6-氨基 - 苯并呋喃基和噻吩基衍生物可以通过使合适的氨基取代的苯甲酰基苯酚与适当的取代的苯乙酮反应并随后修饰取代基来制备。 这些化合物可用于治疗实际和慢性炎性疾病,特别是气道和胃肠道。
-
公开(公告)号:US5385918A
公开(公告)日:1995-01-31
申请号:US15688
申请日:1993-02-09
IPC分类号: A61K31/40 , A61K31/401 , A61K31/445 , A61K38/00 , A61P37/06 , A61P43/00 , C07D207/16 , C07D211/60 , C07K5/02 , C07K5/078 , C07D207/10 , C07D211/32
CPC分类号: C07K5/06165 , C07K5/0207 , C07K5/06139 , A61K38/00
摘要: Compounds which suppress human T-lymphocyte proliferation are disclosed. The active compounds essentially contain at least the following structure: ##STR1## wherein A, R.sup.1, R.sup.2, R.sup.3, n, X.sup.1 and Z are defined in the specification.
摘要翻译: 公开了抑制人T淋巴细胞增殖的化合物。 活性化合物基本上至少包含以下结构:其中A,R1,R2,R3,n,X1和Z在说明书中定义。
-