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31.Substituted 2-thio-3, 5-dicyano-4-phenyl-6-aminopyridines and their use as adenosine receptor-selective ligands 失效
标题翻译: 取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶并将其用作腺苷受体选择配体公开(公告)号:US07045631B2
公开(公告)日:2006-05-16
申请号:US10484133
申请日:2002-07-03
申请人: Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch
发明人: Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch
IPC分类号: C07D213/62 , C07D417/12
CPC分类号: C07D417/12 , C07D213/85
摘要: Compounds of the formula (I) a process for preparing them, and their use as medicaments are described.
摘要翻译: 描述了式(I)化合物的制备方法及其作为药物的用途。
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32.Substituted 2-oxy-3,5-dicyano-4-aryl-6-aminopyridines and use thereof 失效
标题翻译: 取代的2-氧基-3,5-二氰基-4-芳基-6-氨基吡啶及其用途公开(公告)号:US20050261502A1
公开(公告)日:2005-11-24
申请号:US10469556
申请日:2002-02-20
申请人: Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
发明人: Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
IPC分类号: A61K31/44 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61P1/16 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/10 , A61P15/10 , A61P17/00 , A61P25/00 , A61P25/04 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , C07D213/85 , C07D405/04 , C07D409/14 , C07D417/14 , C07D213/84
CPC分类号: C07D405/04 , C07D213/85 , C07D409/14 , C07D417/14
摘要: The use of compounds of formula (I) as medicaments, novel compounds of formula (I) and a method for production thereof are disclosed. Compounds of formula (I) are effective as adenosine receptor ligands.
摘要翻译: 公开了使用式(I)化合物作为药物,新的式(I)化合物及其制备方法。 式(I)化合物作为腺苷受体配体是有效的。
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33.Substituted 2, 6-diamino-3, 5-dicyano-4-arylpyridines and their use as adenosine-receptor-selective ligands 失效
标题翻译: 取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶及其作为腺苷受体选择配体的用途公开(公告)号:US20070213372A1
公开(公告)日:2007-09-13
申请号:US11607262
申请日:2006-12-01
申请人: Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
发明人: Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
IPC分类号: A61K31/44 , C07D213/02
CPC分类号: C07D401/12 , C07D213/85 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/14
摘要: The present invention relates to substituted 2,6-diamino-3,5-dicyano-4-arylpyridines of the formula (I) wherein the definitions of substituent groups R1-R7 are as provided in the specification and claims, to a pharmaceutical composition containing such a compound, to a process for preparation of such materials, and to their use as medicaments for the treatment of cardiovascular disorders and diabetes.
摘要翻译: 本发明涉及式(I)的取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶,其中取代基R 1〜R 7的定义< SUP>如说明书和权利要求书中所述,涉及含有这种化合物的药物组合物,其制备方法和用作治疗心血管疾病和糖尿病的药物。
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公开(公告)号:US20060264432A1
公开(公告)日:2006-11-23
申请号:US11359927
申请日:2006-02-21
申请人: Ulrich Rosentreter , Rolf Henning , Marcus Bauser , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Klaus Dembowsky , Olga Salcher-Schraufstatter , Johannes-Peter Stasch , Thomas Krahn , Elisabeth Perzborn
发明人: Ulrich Rosentreter , Rolf Henning , Marcus Bauser , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Klaus Dembowsky , Olga Salcher-Schraufstatter , Johannes-Peter Stasch , Thomas Krahn , Elisabeth Perzborn
IPC分类号: A61K31/5377 , A61K31/496 , A61K31/4545 , A61K31/4439 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号: C07D401/12 , C07D213/85 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: The invention relates to compounds of general formula (I), a method for the production thereof and the use thereof as pharmacologically effective substances for a broad medical indication spectrum. Furthermore, selective adenosine receptor ligands, preferably selective adenosine A1-, adenosine A2a- and/or adenosine A2b-receptor ligands are provided for the prophylaxis and/or the treatment of diseases, especially cardiovascular diseases, diseases of the urogenital region, diseases of the respiratory tract, inflammatory and neuroinflammatory diseases, diabetes, especially pancreatic diabetes, neurodegenerative diseases, pain states, cancer as well as liver fibrosis and liver cirrhosis.
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公开(公告)号:US20060154969A1
公开(公告)日:2006-07-13
申请号:US10471079
申请日:2002-02-28
申请人: Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
发明人: Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
IPC分类号: A61K31/44 , C07D213/84
CPC分类号: C07D401/12 , C07D213/85 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14
摘要: The invention relates to the compounds of formula (I), to a method for producing the same and to the use thereof as medicaments.
摘要翻译: 本发明涉及式(I)化合物,其制备方法及其作为药物的用途。
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36.Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same 有权
标题翻译: 取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶并使用它们公开(公告)号:US20050227972A1
公开(公告)日:2005-10-13
申请号:US10497120
申请日:2002-11-28
申请人: Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
发明人: Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
IPC分类号: A61K31/454 , A61K31/4545 , A61K31/5377 , A61K45/00 , A61P3/10 , A61P9/00 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/10 , A61P15/00 , A61P15/10 , A61P17/00 , A61P25/00 , A61P25/04 , A61P25/28 , A61P29/00 , A61P29/02 , A61P35/00 , A61P43/00 , C07D213/85 , C07D417/12 , C07D417/14 , A61K31/541 , A61K31/444 , A61K31/496 , C07D413/14
CPC分类号: C07D417/12 , C07D213/85 , C07D417/14
摘要: Compounds of the formula (I) a process for their preparation and their use as medicaments are described.
摘要翻译: 描述了式(I)化合物的制备方法及其作为药物的用途。
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公开(公告)号:US20080269300A1
公开(公告)日:2008-10-30
申请号:US11661820
申请日:2005-08-30
申请人: Jens-Kerim Erguden , Gunter Karig , Ulrich Rosentreter , Barbara Albrecht , Kerstin Henninger , Joachim Hutter , Nicole Diedrichs , Peter Nell , Sabine Arndt , Walter Hubsch , Andreas Knorr , Karl-Heinz Schlemmer , Dirk Brohm
发明人: Jens-Kerim Erguden , Gunter Karig , Ulrich Rosentreter , Barbara Albrecht , Kerstin Henninger , Joachim Hutter , Nicole Diedrichs , Peter Nell , Sabine Arndt , Walter Hubsch , Andreas Knorr , Karl-Heinz Schlemmer , Dirk Brohm
IPC分类号: A61K31/4439 , C07D417/12 , A61P9/12
CPC分类号: C07D417/12
摘要: The present application relates to novel phenylaminothiazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译: 本申请涉及新的苯基氨基噻唑衍生物,其制备方法,其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途,优选用于治疗和/ 或预防高血压和其他心血管疾病。
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38.
公开(公告)号:US5418243A
公开(公告)日:1995-05-23
申请号:US166775
申请日:1993-12-14
申请人: Rolf Angerbauer , Peter Fey , Walter Hubsch , Thomas Philipps , Hilmar Bischoff , Hans-Peter Krause , Jorg Peterson-von Gehr , Delf Schmidt
发明人: Rolf Angerbauer , Peter Fey , Walter Hubsch , Thomas Philipps , Hilmar Bischoff , Hans-Peter Krause , Jorg Peterson-von Gehr , Delf Schmidt
IPC分类号: A61K31/44 , A61K31/4418 , A61K31/4425 , A61K31/443 , A61K31/4433 , A61K31/66 , A61P3/06 , A61P9/10 , A61P31/00 , A61P43/00 , C07D213/64 , C07D213/79 , C07D405/06 , C07F7/18 , C07F9/32 , C07F9/58 , C07F9/6574
CPC分类号: C07D213/64 , C07D405/06 , C07F7/1856 , C07F9/582
摘要: Substituted 4-phenyl-pyridones and 4-phenyl-2-alkoxypyridines are prepared by reducing corresponding 4-phenyl-pyridone and 4-phenyl-2-alkoxypyridine derivatives. The substituted 4-phenyl-pyridones and 4-phenyl-2-alkoxypyridines can be employed as active compounds in medicaments, in particular for the treatment of hyperlipoproteinaemia.
摘要翻译: 通过还原相应的4-苯基 - 吡啶酮和4-苯基-2-烷氧基吡啶衍生物制备取代的4-苯基 - 吡啶酮和4-苯基-2-烷氧基吡啶。 取代的4-苯基 - 吡啶酮和4-苯基-2-烷氧基吡啶可用作药物中的活性化合物,特别是用于治疗高脂蛋白血症。
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39.Substituted pyridines heptenoic acid derivatives, useful for treating arterioscleros, lipopotaemia and the like 失效
标题翻译: 可用于治疗动脉硬化,脂肪血症等的取代的吡啶庚烯酸衍生物公开(公告)号:US5401746A
公开(公告)日:1995-03-28
申请号:US916928
申请日:1992-07-20
申请人: Rolf Angerbauer , Peter Fey , Walter Hubsch , Thomas Philipps , Hilmar Bischoff , Dieter Petzinna , Delf Schmidt , Gunter Thomas
发明人: Rolf Angerbauer , Peter Fey , Walter Hubsch , Thomas Philipps , Hilmar Bischoff , Dieter Petzinna , Delf Schmidt , Gunter Thomas
IPC分类号: C07D213/55 , C07D213/80 , C07D213/82 , C07D213/85 , C07D213/89 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07F7/08 , C07F7/18 , A61K31/44
CPC分类号: C07D213/80 , C07D213/55 , C07D213/82 , C07D213/85 , C07D213/89 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07F7/0812 , C07F7/0818 , C07F7/1856
摘要: Novel compounds for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis of the formula ##STR1## in which A, B, D and E can have varied meanings,X is --CH.sub.2 --CH.sub.2 or --CH.dbd.CH--, andR is ##STR2## wherein R.sup.21 --denotes hydrogen or alkyl andR.sup.22 --denotes hydrogen,denotes alkyl, aryl or aralkyl, ordenotes a cation,and their oxidation products.
摘要翻译: 用于治疗高蛋白血症,脂蛋白血症或动脉硬化的新型化合物具有下式:X为-CH 2 -CH 2或-CH = CH-,R为R 22为氢,表示烷基,芳基或芳烷基,或表示阳离子,和 它们的氧化产物。
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公开(公告)号:US5138090A
公开(公告)日:1992-08-11
申请号:US486050
申请日:1990-02-27
申请人: Peter Fey , Rolf Angerbauer , Walter Hubsch , Thomas Philipps , Hilmar Bischoff , Peter Petzinna , Delf Schmidt
发明人: Peter Fey , Rolf Angerbauer , Walter Hubsch , Thomas Philipps , Hilmar Bischoff , Peter Petzinna , Delf Schmidt
IPC分类号: A61K31/19 , A61K31/215 , A61K31/365 , A61K31/366 , A61P3/06 , C07C17/26 , C07C22/04 , C07C33/26 , C07C43/178 , C07C45/30 , C07C45/51 , C07C47/277 , C07C47/575 , C07C51/09 , C07C59/48 , C07C59/64 , C07C67/00 , C07C67/31 , C07C69/14 , C07C69/675 , C07C69/732 , C07C69/734 , C07C69/738 , C07C251/24 , C07C255/46 , C07C309/30 , C07D309/30 , C07F7/18 , C07F15/00
CPC分类号: C07F15/006 , C07C22/04 , C07C33/26 , C07C43/1782 , C07C45/305 , C07C45/516 , C07C47/277 , C07C47/575 , C07D309/30 , C07F7/1852
摘要: Substituted biphenyls can be prepared by reduction of appropriate ketones and, if appropriate, subsequent hydrolysis, cyclization, hydrogenation and separation of isomers. The substituted biphenyls can be used as active compounds in medicaments.
摘要翻译: 取代的联苯可以通过还原适当的酮,如果合适的话,可以随后的水解,环化,氢化和异构体的分离来制备。 取代的联苯可以用作药物中的活性化合物。
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