摘要:
The invention relates to new diazephines of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined herein, processes for preparing them and their use as pharmaceutical compositions useful for treating PAF-induced disease.
摘要:
The invention relates to new thieno-triazolo-1,4-diazepino-2-carboxylic acid amides of formula I ##STR1## wherein R.sub.1 represents hydrogen, a C.sub.1-C.sub.4 straight-chained or branched alkyl which can optionally be substituted by halogen, preferably C1 or Br, or by hydroxy, cyclopropyl, C.sub.1 -C.sub.3 alkoxy, preferably methoxy, or halogen, preferably chlorine or bromine;R.sub.2 and R.sub.3, each independently, represent hydrogen, a C.sub.1 -C.sub.4 straight-chained or branched alkyl, C.sub.1 -C.sub.4 hydroxyalkyl or the two groups R.sub.2 and R.sub.3 together with the nitrogen atom represent a 5-, 6- or 7-membered ring which optionally contains a nitrogen, oxygen or sulfur atom as a further heteroatom, the second nitrogen atom optionally being substituted by a C.sub.1 -C.sub.4 alkyl, preferably a methyl group;R.sub.4 represents alpha-pyridyl or a phenyl in which the phenyl ring can be substituted preferably in the 2-position, by methyl, halogen, preferably chlorine or bromine, nitro or trifluoromethyl;n represents one of the numbers 0, 1, 2, 3, 4, 5, 6, 7 or 8; and novel intermediates therefor.The compounds of formula I are useful in the treatment of pathological conditions and diseases in which platelet activating factor is implicated.
摘要:
A two-way communication system for transmitting command signals to and receiving operating data from a winning machine utilized in underground mining operations. The system includes a send-receive facility positioned remote from the winning machine for transmitting command information to the winning machine. A receiving means is positioned at the winning machine for receiving signals sent by the send-receive facility, and a transmitting means is positioned at the winning machine for transmitting signals corresponding to operating data of the winning machine. The send-receive facility receives the information transmitted by the transmitting means, and a separable memory is separably attached to the send-receive facility for storing such operating data and the command information. Because the memory is separable, the memory may be removed to allow the data contained therein to be analyzed at a remote location.
摘要:
The invention discloses a method of treating an individual having a disorder responsive to PAF-antagonist activity by treating the individual with a compound of formula I or II ##STR1## wherein A is an anellated and optionally substituted benzene or 5- or 6-membered heterocyclic ring; R.sub.5 and Z are each independently hydrogen or an optionally substituted C.sub.1 -C.sub.8 alkyl, alkenyl or alkynyl; R.sub.6 is an optionally substituted phenyl, or is thienyl or is .alpha.-pyridyl; Y is CO, CS or CH.sub.2 ; and nontoxic, pharmaceutically acceptable acid addition salts thereof.
摘要翻译:本发明公开了一种通过用式I或II化合物或其药学上可接受的盐或其药物可接受的方法治疗患有对PAF拮抗剂活性的病症的个体的方法。 取代的苯或5-或6-元杂环; R 5和Z各自独立地为氢或任选取代的C 1 -C 8烷基,烯基或炔基; R6是任选取代的苯基,或是噻吩基或是α-吡啶基; Y是CO,CS或CH2; 和无毒的药学上可接受的酸加成盐。
摘要:
This invention relates to a compound of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4, which may be the same or different, each represent a hydrogen or halogen atom or an alkyl or alkoxy group of from 1 to 6 carbon atoms;R.sub.5 and R.sub.6, which may be the same or different, each represent a hydrogen atom, an alkyl group of from 1 to 6 carbon atoms, or an alkenyl group of from 3 to 6 carbon atoms, or R.sub.5 and R.sub.6 together with the nitrogen atom to which they are attached represent a pyrrolidino, piperidino, or morpholino group; andX represents oxygen, sulfur, or a methylene group,or a non-toxic, pharmacologically acceptable acid addition salt thereof, or a racemate, enantiomer, or mixture of enantiomers thereof. The compounds of Formula I are useful in pharmaceutical compositions for treating bronchial asthma and allergic bronchitis.
摘要:
The invention relates to new pseudopeptides having an antiviral action, oft he general formula (I) ##STR1## with the meanings given in the description for the substituents, to a process for their preparation and to their use as antiviral agents, in particular against cytomegaloviruses.
摘要:
A drum-cutter mining machine for longwall mining operations which is adaptable for use upon longwall conveyor systems having rack structures positioned on either, or both, sides thereof. Drive motors are removably supported in a capstan housing of the mining machine, and positioned such that rotating shafts thereof extend toward either or both sides of the mining machine. Drive wheels coupled to the rotating shafts through reduction gears engage with the rack structures to allow translation of the machine therealong. When the mining machine is to be utilized on a longwall conveyor system having an alternate rack structure position, the drive motors may be removed, reoriented, reinserted into the capstan housing, and the drive wheels may be repositioned to allow operation of the mining machine.
摘要:
The invention relates to a device for setting fastener elements or pins, particularly to a screw-setting device. The device comprises a housing in which a retainer shaft for a setting tool is mounted at least for axial displacement, at least one advance drive mechanism within the housing and adapted to be connected to the retainer shaft, a switching sleeve mounted for displacement together with the retainer shaft and defining at least one switch-off point, at least one sensor device supported in the housing for defining the switch-off point, and an adjustment mechanism for adjusting the switch-off point. In known devices of this type, the accurate and rapid adjustment of the switch-off point is difficult. According to the invention the adjustment mechanism is provided within the housing between the switching sleeve and the retainer shaft. The retainer shaft additionally or alternatively cooperates with a stop to limit its stroke within the range of the stroke of the advance drive mechanism with the aid of the switching sleeve to thereby prevent the retainer shaft from being advanced excessively beyond the switch-off point in the absence of a fastener element.