公开(公告)号：US20110189203A1

公开(公告)日：2011-08-04

申请号：US12745023

申请日：2008-11-27

申请人： Guy Hermans ,  Hilde Adi Pierrette Revets ,  Michael John Scott Saunders

发明人： Guy Hermans ,  Hilde Adi Pierrette Revets ,  Michael John Scott Saunders

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K16/24 ,  C07K16/28 ,  C07H21/04 ,  C12P21/06 ,  C12N5/16 ,  A61P35/00

CPC分类号： C07K16/2863 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/3007 ,  C07K16/32 ,  C07K16/468 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/32 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/569 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/94 ,  C07K2319/00

摘要： The present invention relates to protein and polypeptide constructs that comprise single variable domains that are linked to an Fc portion. The immunoglobulin constructs comprise two polypeptide chains in which each polypeptide chain comprises two or more single variable domains that are linked, usually via a suitable hinge region or linker, to one or more constant domains that, together, form an Fc portion. The invention also relates to polypeptide chains that form part of such constructs and/or that can be used to form such constructs. The invention further relates to nucleotide sequences and nucleic acids that encode or can be used to express such constructs or polypeptide chains; to methods for producing such constructs and polypeptides chains; to compositions (and in particular pharmaceutical compositions) that comprise such constructs or polypeptide chains; and to uses of such constructs, polypeptide chains or compositions.

摘要翻译： 本发明涉及包含与Fc部分连接的单个可变结构域的蛋白质和多肽构建体。 免疫球蛋白构建体包含两条多肽链，其中每个多肽链包含两个或更多个单可变结构域，其通常通过合适的铰链区或接头连接到一个或多个恒定区，一起形成Fc部分。 本发明还涉及形成这种构建体的一部分的多肽链和/或可用于形成此类构建体的多肽链。 本发明还涉及编码或可用于表达此类构建体或多肽链的核苷酸序列和核酸; 涉及产生这种构建体和多肽链的方法; 包括这样的构建体或多肽链的组合物（特别是药物组合物）; 以及这种构建体，多肽链或组合物的用途。