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公开(公告)号:US06447773B1
公开(公告)日:2002-09-10
申请号:US09416874
申请日:1999-10-13
申请人: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Andrew Fosberry , Elizabeth J Lawlor
发明人: Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Raymond Winfield Reichard , Richard Oakley Nicholas , Martin Karl Russel Burnham , Julie M Pratt , Martin Rosenberg , Judith M Ward , Andrew Fosberry , Elizabeth J Lawlor
IPC分类号: A61K3848
CPC分类号: C07K16/1275 , A61K39/00 , C07K14/31 , C12N9/78 , C12Y305/04025
摘要: The invention provides clpL polypeptides and DNA (RNA) encoding clpL polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing polypeptides to screen for antibacterial compounds.
摘要翻译: 本发明提供了clpL多肽和编码clpL多肽的DNA(RNA)和通过重组技术产生这种多肽的方法。 还提供了利用多肽来筛选抗菌化合物的方法。
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公开(公告)号:US5869290A
公开(公告)日:1999-02-09
申请号:US752132
申请日:1996-11-21
IPC分类号: G01N33/53 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/04 , C07K14/395 , C07K14/40 , C07K16/14 , C12N5/10 , C12N15/09 , C12N15/31 , C12Q1/68 , C12N15/00 , C07K14/00
CPC分类号: C07K14/40 , A61K38/00 , A61K48/00 , Y10S530/824
摘要: The invention provides caYAE1 polypeptides and DNA (RNA) encoding such caYAE1 and a procedure for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such caYAE1 for the treatment of infection, particularly fungal infections. Antagonists against such caYAE1 and their use as a therapeutic to treat infections, particularly fungal infections are also provided. Further provided are diagnostic assays for detecting diseases related to the presence of caYAE1 nucleic acid sequences and the polypeptides in a host. Also provided are diagnostic assays for detecting polynucleotides encoding caYAE1 and for detecting the polypeptide in a host.
摘要翻译: 本发明提供了编码这种caYAE1的caYAE1多肽和DNA(RNA),以及通过重组技术产生此类多肽的方法。 还提供了利用这种caYAE1治疗感染,特别是真菌感染的方法。 还提供了抗这种caYAE1的拮抗剂及其用作治疗感染特别是真菌感染的治疗剂。 还提供了用于检测与宿主中caYAE1核酸序列和多肽的存在相关的疾病的诊断测定。 还提供了用于检测编码caYAE1的多核苷酸并用于检测宿主中的多肽的诊断测定。
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