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110 条记录 (耗时 0.057 秒)

    Modulators of Metabolism and the Treatment of Disorders Related Thereto
    31.
    发明申请
    Modulators of Metabolism and the Treatment of Disorders Related Thereto 审中-公开
    代谢调节剂及其相关疾病的治疗

    公开(公告)号：US20100160359A1

    公开(公告)日：2010-06-24

    申请号：US11992024

    申请日：2006-09-14

    申请人： Robert M. Jones ,  Juerg Lehmann

    发明人： Robert M. Jones ,  Juerg Lehmann

    IPC分类号： A61K31/506 ,  C07D401/14 ,  A61P3/00 ,  A61P3/10 ,  A61P3/06

    CPC分类号： C07D401/14

    摘要： The present invention relates to 4-[5-methyl-6-(2-methyl-pyridin-3-yloxy)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester, pharmaceutically acceptable salts, solvates and hydrates thereof that are modulators of glucose metabolism. Accordingly, compounds of the present invention are useful in the treatment of metabolic-related disorders and complications thereof, such as, diabetes and obesity.

    摘要翻译： 本发明涉及4- [5-甲基-6-（2-甲基 - 吡啶-3-基氧基） - 嘧啶-4-基氧基] - 哌啶-1-甲酸异丙酯，其药学上可接受的盐，溶剂合物和水合物 这是葡萄糖代谢的调节剂。 因此，本发明的化合物可用于治疗代谢相关疾病及其并发症，例如糖尿病和肥胖症。

    Crystalline forms and processes for the preparation of cannabinoid receptor modulators
    35.
    发明授权
    Crystalline forms and processes for the preparation of cannabinoid receptor modulators 有权
    用于制备大麻素受体调节剂的结晶形式和方法

    公开(公告)号：US09458136B2

    公开(公告)日：2016-10-04

    申请号：US14001133

    申请日：2012-02-24

    申请人： Anthony C. Blackburn ,  Sangdon Han ,  Robert M. Jones ,  Antonio Garrido Montalban ,  Biman B. Pal ,  Jaimie Karyn Rueter

    发明人： Anthony C. Blackburn ,  Sangdon Han ,  Robert M. Jones ,  Antonio Garrido Montalban ,  Biman B. Pal ,  Jaimie Karyn Rueter

    IPC分类号： A61K31/4965 ,  C07D403/04 ,  A61K31/497

    CPC分类号： C07D403/04 ,  A61K31/497 ,  A61P29/00 ,  C07B2200/13

    摘要： The present invention relates to crystalline forms of (1aS,5aS)-2-(4-oxy-pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid ((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-amide (Compound 1) and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor and are therefore useful in the treatment of CB2 receptor-mediated disorders, for example, osteoarthritis; pain; hyperalgesia; allodynia; inflammatory hyperalgesia; neuropathic hyperalgesia; acute nociception; osteoporosis; multiple sclerosis-associated spasticity; autoimmune disorders; allergic reactions; CNS inflammation for example; atherosclerosis; undesired immune cell activity, and inflammation associated with a disorder selected from: osteoarthritis, anaphylaxis, Behcet's disease, graft rejection, vasculitis, gout, spondylitis, viral disease, bacterial disease, lupus, inflammatory bowel disease, autoimmune hepatitis, and type 1 diabetes mellitus; age-related macular degeneration; cough; leukemia; lymphoma; CNS tumors; prostate cancer; Alzheimer's disease; stroke-induced damage; dementia; amyotrophic lateral sclerosis; and Parkinson's disease.

    摘要翻译： 本发明涉及（1aS，5aS）-2-（4-氧 - 吡嗪-2-基）-1a，2,5,5a-四氢-1H-2,3-二氮杂 - 环丙烷[a] 顺式-4-羧酸（（S）-1-羟甲基-2,2-二甲基 - 丙基） - 酰胺（化合物1）及其药物组合物，其调节大麻素CB2受体的活性，因此可用于治疗 CB2受体介导的疾病，例如骨关节炎; 疼痛; 痛觉过敏 异常性疼痛 炎性痛觉过敏; 神经性痛觉过敏; 急性伤害感受 骨质疏松症 多发性硬化相关性痉挛状态; 自身免疫性疾病 过敏反应; CNS炎症例如; 动脉粥样硬化 不良免疫细胞活性和与选自以下的疾病相关的炎症：骨关节炎，过敏反应，贝切特氏病，移植排斥反应，血管炎，痛风，脊椎炎，病毒性疾病，细菌性疾病，狼疮，炎性肠病，自身免疫性肝炎和1型糖尿病 ; 年龄相关性黄斑变性; 咳嗽; 白血病; 淋巴瘤 CNS肿瘤; 前列腺癌; 阿尔茨海默氏病; 中风引起的损伤; 痴呆; 肌萎缩性侧索硬化; 和帕金森病。

    CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF CANNABINOID RECEPTOR MODULATORS
    36.
    发明申请
    CRYSTALLINE FORMS AND PROCESSES FOR THE PREPARATION OF CANNABINOID RECEPTOR MODULATORS 有权
    用于制备CANNABINOID受体调节剂的晶体形式和方法

    公开(公告)号：US20140135345A1

    公开(公告)日：2014-05-15

    申请号：US14001133

    申请日：2012-02-24

    申请人： Anthony C. Blackburn ,  Sangdon Han ,  Robert M. Jones ,  Antonio Garrido Montalban ,  Biman B. Pal ,  Jaimie Karyn Rueter

    发明人： Anthony C. Blackburn ,  Sangdon Han ,  Robert M. Jones ,  Antonio Garrido Montalban ,  Biman B. Pal ,  Jaimie Karyn Rueter

    IPC分类号： C07D403/04

    CPC分类号： C07D403/04 ,  A61K31/497 ,  A61P29/00 ,  C07B2200/13

    摘要： The present invention relates to crystalline forms of (1aS,5aS)-2-(4-oxy-pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid ((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-amide (Compound 1) and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor and are therefore useful in the treatment of CB2 receptor-mediated disorders, for example, osteoarthritis; pain; hyperalgesia; allodynia; inflammatory hyperalgesia; neuropathic hyperalgesia; acute nociception; osteoporosis; multiple sclerosis-associated spasticity; autoimmune disorders; allergic reactions; CNS inflammation for example; atherosclerosis; undesired immune cell activity, and inflammation associated with a disorder selected from: osteoarthritis, anaphylaxis, Behcet's disease, graft rejection, vasculitis, gout, spondylitis, viral disease, bacterial disease, lupus, inflammatory bowel disease, autoimmune hepatitis, and type 1 diabetes mellitus; age-related macular degeneration; cough; leukemia; lymphoma; CNS tumors; prostate cancer; Alzheimer's disease; stroke-induced damage; dementia; amyotrophic lateral sclerosis; and Parkinson's disease.

    摘要翻译： 本发明涉及（1aS，5aS）-2-（4-氧 - 吡嗪-2-基）-1a，2,5,5a-四氢-1H-2,3-二氮杂 - 环丙烷[a] 顺式-4-羧酸（（S）-1-羟甲基-2,2-二甲基 - 丙基） - 酰胺（化合物1）及其药物组合物，其调节大麻素CB2受体的活性，因此可用于治疗 CB2受体介导的病症，例如骨关节炎; 疼痛; 痛觉过敏 异常性疼痛 炎性痛觉过敏; 神经性痛觉过敏; 急性伤害感受 骨质疏松症 多发性硬化相关性痉挛状态; 自身免疫性疾病 过敏反应; CNS炎症例如; 动脉粥样硬化 不良免疫细胞活性和与选自以下的疾病相关的炎症：骨关节炎，过敏反应，贝切特氏病，移植排斥反应，血管炎，痛风，脊椎炎，病毒性疾病，细菌性疾病，狼疮，炎性肠病，自身免疫性肝炎和1型糖尿病 ; 年龄相关性黄斑变性; 咳嗽; 白血病; 淋巴瘤 CNS肿瘤; 前列腺癌; 阿尔茨海默氏病; 中风引起的损伤; 痴呆; 肌萎缩性侧索硬化; 和帕金森病。

    Generic crimped rotor for an electric brushless direct current motor
    39.
    发明授权
    Generic crimped rotor for an electric brushless direct current motor 有权
    用于电动无刷直流电动机的通用卷曲转子

    公开(公告)号：US07994675B2

    公开(公告)日：2011-08-09

    申请号：US12569890

    申请日：2009-09-29

    申请人： Robert M. Jones ,  Joseph M. Lisiecki

    发明人： Robert M. Jones ,  Joseph M. Lisiecki

    IPC分类号： H02K1/30

    CPC分类号： H02K1/278 ,  H02K3/38 ,  H02K5/04 ,  H02K5/18 ,  H02K5/225 ,  H02K11/33 ,  H02K16/00 ,  H02K21/16 ,  H02K29/08 ,  H02K2213/12

    摘要： A rotor having a substantially cylindrical configuration for use in a brushless direct current electric motor having a high torque to size ratio. The rotor has an outer peripheral surface. The rotor also has a central rotor shaft and a first and second retaining ends mounted on the central rotor shaft and spaced from one another. The rotor also has a plurality of magnets configured to provide a magnetic flux with a stator disposed around the central rotor shaft. The magnets are radially disposed on the shaft and the rotor also has a sheath. The sheath is crimped around the radially disposed permanent magnets, and holds the magnets around the shaft. The sheath is lightweight and minimizes a gap between the permanent magnets and the stator to provide for an electromagnetic flux between the magnets and the stator windings, and for rotation of the central rotor shaft.

    摘要翻译： 具有大体圆柱形构造的转子，用于具有高扭矩与大尺寸比的无刷直流电动机。 转子具有外周面。 转子还具有中心转子轴和安装在中心转子轴上并彼此间隔开的第一和第二保持端。 转子还具有多个磁体，其被配置为提供磁通量，该定子设置在中心转子轴周围。 磁体径向设置在轴上，转子也具有护套。 鞘被卷绕在径向设置的永磁体周围，并将磁体保持在轴周围。 护套是轻质的，并且使永磁体和定子之间的间隙最小化，以提供磁体和定子绕组之间的电磁通量，并且用于中心转子轴的旋转。