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公开(公告)号:US20070020308A1
公开(公告)日:2007-01-25
申请号:US11184223
申请日:2005-07-19
申请人: Robert Richard , Rudolf Faust
发明人: Robert Richard , Rudolf Faust
IPC分类号: A61K31/74
CPC分类号: A61K47/58
摘要: Therapeutic polymers are described, which contain at least one polymeric portion and at least one therapeutic agent. The therapeutic agent and the polymeric portion are covalently linked via one or more linkages which hydrolyze in an aqueous environment, for example, one or more linkages selected from an Si—N linkage, an Si—O linkage, and a combination of the same. Other aspects the invention are directed to methods of making the above therapeutic polymers.
摘要翻译: 描述了含有至少一个聚合物部分和至少一种治疗剂的治疗性聚合物。 治疗剂和聚合物部分通过在水性环境中水解的一种或多种键共价连接,例如一种或多种选自Si-N键,Si-O键及其组合的键。 本发明的其它方面涉及制备上述治疗性聚合物的方法。
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公开(公告)号:US20060171981A1
公开(公告)日:2006-08-03
申请号:US11048613
申请日:2005-02-01
申请人: Robert Richard , Marlene Schwarz , Rudolf Faust
发明人: Robert Richard , Marlene Schwarz , Rudolf Faust
摘要: According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions. These polymeric regions, in turn, contain one or more polymers, at least one of which is a copolymer that includes the following: (a) one or more unsaturated hydrocarbon monomer species and (b) one or more heteroatom-containing monomer species.
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公开(公告)号:US20050187414A1
公开(公告)日:2005-08-25
申请号:US10902280
申请日:2004-07-29
申请人: Rudolf Faust , Yonghua Zhou
发明人: Rudolf Faust , Yonghua Zhou
IPC分类号: C08F8/12 , C08F210/10 , C08F216/12 , C08F297/00 , C11D7/18
CPC分类号: C08F216/12 , C08F210/10 , C08F297/00 , C08F216/14 , C08F2500/03
摘要: Novel copolymers, including block copolymers, that comprise: (a) a plurality of constitutional units that correspond to one or more branched olefin monomer species and (b) a plurality of constitutional units that correspond to one or more vinyl ether monomer species, which vinyl ether monomer species are selected from (i) hydrolysable vinyl ether monomer species and (ii) elevated-Tg vinyl ether monomer species. Also described herein are methods of forming such copolymers. Also described are novel copolymers, including block copolymers, which comprise: (a) a plurality of constitutional units that correspond to one or more branched olefin monomer species and (b) a plurality of constitutional units that correspond to vinyl alcohol.
摘要翻译: 新型共聚物,包括嵌段共聚物,其包含:(a)对应于一种或多种支链烯烃单体种类的多个结构单元和(b)对应于一种或多种乙烯基醚单体种类的多个结构单元,所述乙烯基 醚单体种类选自(i)可水解的乙烯基醚单体种类和(ii)升高的T O乙烯基醚单体种类。 本文还描述了形成这种共聚物的方法。 还描述了包括嵌段共聚物的新型共聚物,其包含:(a)对应于一种或多种支链烯烃单体种类的多个结构单元和(b)对应于乙烯醇的多个结构单元。
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公开(公告)号:US20050143526A1
公开(公告)日:2005-06-30
申请号:US10872134
申请日:2004-06-18
申请人: Rudolf Faust , Axel Mueller
发明人: Rudolf Faust , Axel Mueller
CPC分类号: C08F297/00 , C08F8/30 , C08F110/10 , C08F295/00 , C08F297/02 , C08F297/026 , C08F2810/40 , C08F8/00 , C08F10/10 , C08F8/42 , C08F4/00 , C08F2/38 , C08F2500/03 , C08F8/34
摘要: Methods are described herein for converting carbocationically terminated polymers to anionically terminated polymers. These methods comprise: (a) providing a carbocationically terminated polymeric moiety; (b) reacting the carbocationically terminated polymeric moiety with a heterocyclic compound of the formula where —X— is selected from —S—, —O—, —NH— and —NR—, and where R is an alkyl group or an aryl group, thereby providing an end-capped polymeric moiety; and (c) reacting the end-capped polymeric moiety with an organolithium compound to yield an anionically terminated polymeric moiety. Also described are block copolymers in which a first polymer block comprising cationically polymerized monomers is linked to a second polymer block comprising anionically polymerized monomers by a group, as well as a polymer in which a polymer block comprising cationically polymerized monomers is linked to a halogenated silane residue or a carbosilane residue by a group.
摘要翻译: 本文描述了将碳阳离子封端的聚合物转化成阴离子封端的聚合物的方法。 这些方法包括:(a)提供碳阳离子封端的聚合物部分; (b)使碳阳离子封端的聚合物部分与下式的杂环化合物反应,其中-X-选自-S-, - O - , - NH-和-NR-,其中R是烷基或芳基 ,从而提供封端的聚合物部分; 和(c)使封端的聚合物部分与有机锂化合物反应,得到阴离子封端的聚合物部分。 还描述了嵌段共聚物,其中包含阳离子聚合的单体的第一聚合物嵌段与包含阴离子聚合的单体的第二聚合物嵌段连接,其中包含阳离子聚合的单体的聚合物嵌段与卤代硅烷 残基或碳硅烷残基。
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公开(公告)号:US06750267B2
公开(公告)日:2004-06-15
申请号:US10036096
申请日:2001-12-24
IPC分类号: C08F250
摘要: Disclosed herein are radiation-curable polymers, a method of preparing radiation-curable polymers and compositions containing radiation-curable polymers. Radiation-curable polymers and compositions containing radiation-curable polymers are useful as coatings and adhesives.
摘要翻译: 本文公开了可辐射固化聚合物,制备可辐射固化聚合物的方法和含有可辐射固化聚合物的组合物。 含可辐射固化聚合物的可辐射固化聚合物和组合物可用作涂料和粘合剂。
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公开(公告)号:US06469115B1
公开(公告)日:2002-10-22
申请号:US09572135
申请日:2000-05-16
IPC分类号: C08F400
CPC分类号: C08F210/10 , C08F4/00 , C08F2/38
摘要: A method for preparing a moisture-curable, virtually telechelic, silyl-functional polyisobutylene is disclosed, said method comprising reacting, in the presence of a Lewis acid, (A) isobutylene; (B) an initiator of the formula (C) a styryl comonomer of the formula wherein R is selected from H or methyl group, R′ is a divalent non-aromatic hydrocarbon group having 1 to 6 carbon atoms, R″ is independently selected from alkyl groups having 1 to 10 carbon atoms or aryl groups having 6 to 10 carbon atoms, R′″ is a divalent non-aromatic hydrocarbon group having 2 to 6 carbon atoms, X is independently a halogen group, Y is halogen and n is independently 1, 2 or 3.
摘要翻译: 公开了一种制备湿气固化的,实际上是遥爪的甲硅烷基官能的聚异丁烯的方法,所述方法包括在路易斯酸存在下使(A)异丁烯反应;(B)式(C)的引发剂,苯乙烯基 式中R的共聚单体选自H或甲基,R'是具有1至6个碳原子的二价非芳族烃基,R“独立地选自具有1至10个碳原子的烷基或具有6个 至10个碳原子,R“是具有2至6个碳原子的二价非芳族烃基,X独立地为卤素基团,Y为卤素且n独立地为1,2或3。
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公开(公告)号:US5777044A
公开(公告)日:1998-07-07
申请号:US979451
申请日:1997-11-24
申请人: Rudolf Faust
发明人: Rudolf Faust
IPC分类号: C08F297/00 , C08F297/08 , C08F10/10
CPC分类号: C08F297/08 , C08F297/00
摘要: A method for coupling a cationic polymer includes forming a reaction mixture of a cationic polymer and a bis(diphenylethylene). The reaction mixture is exposed to a temperature which causes the bis(diphenylethylene) to react with the cationic polymer, thereby coupling the cationic polymer. In another embodiment, the method includes forming a reaction mixture of an oxo-acid and a isopropenyl polyisobutylene. The reaction mixture is exposed to a temperature below about -30.degree. C., whereby the oxo-acid reacts with isopropenyl polyisobutylene, thereby coupling the polymer.
摘要翻译: 用于偶联阳离子聚合物的方法包括形成阳离子聚合物和双(二苯基乙烯)的反应混合物。 将反应混合物暴露于导致双(二苯基乙烯)与阳离子聚合物反应的温度,从而偶联阳离子聚合物。 在另一个实施方案中,该方法包括形成含氧酸和异丙烯基聚异丁烯的反应混合物。 将反应混合物暴露于低于约-30℃的温度,由此含氧酸与异丙烯基聚异丁烯反应,从而偶联聚合物。
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公开(公告)号:US5665837A
公开(公告)日:1997-09-09
申请号:US173493
申请日:1993-12-23
申请人: Rudolf Faust , Lajos Balogh
发明人: Rudolf Faust , Lajos Balogh
IPC分类号: C08F2/38 , C08F4/14 , C08F10/10 , C08F110/10 , C08F297/00
CPC分类号: C08F297/00 , C08F10/10 , C08F110/10
摘要: A composition of the invention includes a polymer component which consists essentially of an asymmetric telechelic polymer having a boron-containing head group. These asymmetric telechelic polymers can also have halogen tail groups. The end group functionalities make these polymers extremely useful because, for example, the functionalities facilitate subsequent elaboration of the polymer. A method of forming the composition includes forming a reaction mixture which consists essentially of an olefin, a Lewis acid, and a base which will react with essentially all protic impurities in the reaction mixture, thereby preventing protic initiation during polymerization of the olefin. The reaction mixture is exposed to conditions which cause the olefin to react to form an initiator in situ which can cause polymerization of additional olefin to form a polymerized olefin consisting essentially of a telechelic polymer. In another embodiment, the initiator has the structure BX.sub.2 --[CH.sub.2 --C(CH.sub.3).sub.2 ].sub.n A, where "n" is at least one, "X" is a halogen, and "A" is a leaving group.
摘要翻译: 本发明的组合物包括基本上由具有含硼头基的不对称遥爪聚合物组成的聚合物组分。 这些不对称遥爪聚合物也可以具有卤素基团。 端基官能团使得这些聚合物非常有用,因为例如,这些官能团促进了聚合物的后续制备。 形成组合物的方法包括形成基本上由烯烃,路易斯酸和碱反应的反应混合物,其将与反应混合物中的基本上所有的质子杂质反应,从而防止烯烃聚合过程中的质子起始。 将反应混合物暴露于使烯烃反应以原位形成引发剂的条件下,其可引起另外的烯烃的聚合以形成基本上由遥爪聚合物组成的聚合烯烃。 在另一个实施方案中,引发剂具有结构BX2- [CH2-C(CH3)2] nA,其中“n”为至少一个,“X”为卤素,“A”为离去基团。
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公开(公告)号:US4568732A
公开(公告)日:1986-02-04
申请号:US689828
申请日:1985-01-09
申请人: Joseph P. Kennedy , Rudolf Faust , Agota Fehervari
发明人: Joseph P. Kennedy , Rudolf Faust , Agota Fehervari
CPC分类号: C08F10/10
摘要: Novel telechelic halogenated polymers of cationically polymerized olefin monomers are formed carrying from 2 to about 6 terminal halogens by a continuous polymerization method. The continuous polymerization method being achieved by feeding to a stirred reactor a first stream composed of a solvent solution of at least one monomer and an inifer and another stream composed of a solvent solution of boron chloride to effect the polymerization of said monomer to a telechelic halogenated polymer product and withdrawing the reaction product from said reactor essentially in amounts equal to that of the sum of the two streams with the feeds to said reactor being simultaneously and continuously fed thereto while maintaining the temperature in the range of minus 10.degree. to minus 80.degree. C.
摘要翻译: 通过连续聚合法形成携带2至约6个末端卤素的阳离子聚合烯烃单体的新型遥爪卤化聚合物。 连续聚合方法是通过向搅拌反应器中加入由至少一种单体和未反应物的溶剂溶液组成的第一流和由氯化硼的溶剂溶液组成的另一流来实现的,以使所述单体聚合成远端卤代 聚合物产物,并且基本上以等于两种料流之和的量与所述反应器的进料同时并连续地进料到所述反应器中的反应产物,同时保持温度在-10°至-80°的范围内 C。
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公开(公告)号:US09574043B2
公开(公告)日:2017-02-21
申请号:US12685858
申请日:2010-01-12
申请人: Rudolf Faust , Umaprasana Ojha
发明人: Rudolf Faust , Umaprasana Ojha
IPC分类号: C08G18/67 , C08G18/32 , A61L27/18 , A61L27/26 , A61L27/34 , A61L29/04 , A61L29/06 , A61L29/08 , A61L31/06 , A61L31/10 , C08G18/40 , C08G18/48 , C08G18/62 , C08G18/65 , C08G18/76
CPC分类号: C08G18/6204 , A61L27/18 , A61L27/26 , A61L27/34 , A61L29/049 , A61L29/06 , A61L29/085 , A61L31/06 , A61L31/10 , C08G18/32 , C08G18/3206 , C08G18/4063 , C08G18/4854 , C08G18/6511 , C08G18/7671 , C08L75/04
摘要: An elastomeric polymer, comprising (1) a hard segment in the amount of 10% to 60% by weight of the elastomeric polymer, wherein the hard segment includes a urethane, urea or urethaneurea; and (2) a soft segment in the amount of 40% to 90% by weight of the elastomeric polymer. The soft segment comprises (a) at least 2% by weight of the soft segment of at least one polyether macrodiol, and/or at least one polycarbonate macrodiol; and (b) at least 2% by weight of the soft segment of at least one polyisobutylene macrodiol and/or diamine.
摘要翻译: 一种弹性体聚合物,其包含(1)所述弹性体聚合物的10至60重量%的硬链段,其中所述硬链段包括氨基甲酸酯,脲或氨基脲; 和(2)弹性体聚合物的40重量%至90重量%的软链段。 软链段包含(a)至少2重量%的至少一个聚醚大分子二醇的软链段和/或至少一个聚碳酸酯大分子二醇; 和(b)至少2重量%的至少一种聚异丁烯大分子二醇和/或二胺的软链段。
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