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35 条记录 (耗时 0.012 秒)

    {8 (Azidomethyl)thio{9 acetylcephalosporins
    31.
    发明授权
    {8 (Azidomethyl)thio{9 acetylcephalosporins 失效
    {8（叠氮甲基）硫代{9乙酰头孢菌素

    公开(公告)号：US3897422A

    公开(公告)日：1975-07-29

    申请号：US33780473

    申请日：1973-03-05

    申请人： SQUIBB & SONS INC

    发明人： BREUER HERMANN ,  TREUNER UWE D

    IPC分类号： C07D333/24 ,  C07D261/08 ,  C07D277/20 ,  C07D277/30 ,  C07D307/54 ,  C07D501/20 ,  C07D99/24

    CPC分类号： C07D501/20

    摘要： New ((azidomethyl)thio)acetylcephalosporins of the following general formula, and their salts,

    WHEREIN R is hydrogen, lower alkyl, aralkyl, tri(lower alkyl)silyl, a salt forming ion or the group

    R1 is hydrogen or lower alkyl; R2 is hydrogen, lower alkyl, aryl or a heterocyclic group; R3 is lower alkyl, aryl or aralkyl; and X is hydrogen, hydroxy, lower alkanoyloxy, lower alkoxy, lower alkylthio, lower alkylthiazolylthio, azido, the radical of a nitrogen base, or together X and R represent a bond linking carbon and oxygen in a lactone ring; are useful as antibacterial agents.

    摘要翻译： 新的具有下列通式的[（叠氮基甲基）硫代]乙酰头孢菌素及其盐，其中R是氢，低级烷基，芳烷基，三（低级烷基） - 甲硅烷基，成盐离子或基团R 1是氢或低级烷基; R2是氢，低级烷基，芳基或杂环基; R3是低级烷基，芳基或芳烷基; 和X是氢，羟基，低级烷酰氧基，低级烷氧基，低级烷硫基，低级烷基噻唑硫基，叠氮基，氮碱基，或一起X和R表示内酯环中碳和氧的连接键; 作为抗菌剂是有用的。

    Indane derivatives of thiocarbamic acids
    33.
    发明授权
    Indane derivatives of thiocarbamic acids 失效
    氨基酸的衍生物

    公开(公告)号：US3636032A

    公开(公告)日：1972-01-18

    申请号：US3636032D

    申请日：1968-08-06

    申请人： SQUIBB & SONS INC

    发明人： BREUER HERMANN

    IPC分类号： C07C333/02 ,  C07C155/08

    CPC分类号： C07C333/02

    摘要： THIS INVENTION RELATES TO NEW INDANE DERIVATIVES OF SUBSTITUTED THIOCARBAMIC ACIDS, MORE PARTICULARLY, THOSE HAVING THE FORMULA

    3-((INDAN-5-YL)-N(-R1)-C(=S)-O-)NAPHTHALENE

    WHEREIN R1 IS HYDROGEN OR LOWER ALKYL. THESE NEW COMPOUNDS ARE USEFUL AS ANTIFUNGAL AGENTS.

    5-nitrofuryl-1,2,4-oxadiazine derivatives
    34.
    发明授权
    5-nitrofuryl-1,2,4-oxadiazine derivatives 失效
    5-硝基-1,2,4-氧杂环丁烷衍生物

    公开(公告)号：US3574201A

    公开(公告)日：1971-04-06

    申请号：US3574201D

    申请日：1969-07-30

    申请人： SQUIBB & SONS INC

    发明人： BREUER HERMANN

    IPC分类号： A61K31/535 ,  C07D405/06 ,  C07D87/52

    CPC分类号： C07D405/06 ,  A61K31/535

    摘要： 5-NITROFURYL-1,2,4-OXADIAZINES OF THE FORMULA

    3-(O2N-(2,5-FURYLENE)-(CH=CH)N-),5-(R=)-

    5,6-DIHYDRO-4H-1,2,4-OXADIAZINE

    WHEREIN R IS OXYGEN AN IMINO GROUP OR A LOWER ALKANOYLIMINO GROUP AND N IS ZERO OR ONE, ARE USEFUL AS ANTIMICROBIAL AGENTS. A 3-(5-NITRO-2-FURYL)-5HALOMETHYL-1,2,4OXADIAZOLE, UPON TREATMENT WITH AQUEOUS ALKALI IN A SOLVENT OR WITH LIQUID AMOMNIA YIELDS, RESPECTIVELY, A COMPOUND OF THE ABOVE FORMULA WHEREIN R IS OXYGEN OR IMINO. THE IMINO GROUP MAY THEN BE ACYLATED.