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31.发明申请NON-AQUEOUS, SINGLE TUBE DENTRIFICE WHITENING COMPOSITIONS, METHODS OF USE AND MANUFACTURE THEREOF 审中-公开非水性单体组合物，其使用方法及制造方法公开(公告)号：US20120244091A1
公开(公告)日：2012-09-27
申请号：US13513640
申请日：2009-12-04
CPC分类号： A61K8/66 , A61K8/60 , A61K2800/28 , A61K2800/70 , A61Q11/00
摘要： This invention relates to oral care composition, methods of use and methods of manufacture thereof including a single-tube, non-aqueous dentifrice whitening composition containing at least an enzyme and a substrate.
摘要翻译： 本发明涉及口腔护理组合物，其使用方法及其制备方法，其包括至少含有酶和底物的单管非水洁牙剂增白组合物。
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公开(公告)号：US10098829B2
公开(公告)日：2018-10-16
申请号：US14116371
申请日：2011-06-02
申请人： Steven Fisher , Lynette Zaidel , Michael Prencipe
发明人： Steven Fisher , Lynette Zaidel , Michael Prencipe
摘要： A dentifrice composition having a low water phase comprising effective amounts of polyphosphate and ionic active ingredients. The composition comprises a source of metal ions, an inorganic phosphate salt having four or more phosphorus atoms and a cross-linked polyvinylpyrrolidone thickening agent in a single phase. Preferred metal ions are stannous, copper and zinc, in particular from zinc citrate and stannous fluoride.
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33.发明授权公开(公告)号：US09937365B2
公开(公告)日：2018-04-10
申请号：US13262010
申请日：2010-04-01
CPC分类号： A61Q11/00 , A61K8/19 , A61K8/20 , A61K8/25 , A61K2800/412
摘要： The invention encompasses combinations of bioactive glass composition and potassium salts that are useful in conjunction with delivery agent such as, for example, toothpastes, mouthwashes, and oral gels. In certain embodiments, the compositions of the invention form a rapid and continuous reaction with body fluids (e.g., saliva) to promote the immediate and long-tem release of Ca and P ions to produce a stable crystalline layer deposited onto and into the dentin tubules for the immediate and long term reduction of dentin hypersensitivity and tooth surface remineralization.
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公开(公告)号：US08591868B2
公开(公告)日：2013-11-26
申请号：US13296282
申请日：2011-11-15
CPC分类号： A61K8/22 , A61K8/20 , A61K8/25 , A61K8/463 , A61K8/737 , A61K8/8152 , A61K8/8176 , A61K8/86 , A61K8/88 , A61K8/89 , A61Q11/00
摘要： The invention provides a single phase whitening dentifrice that includes (i) a whitening agent selected from the group consisting of hydrogen peroxide, a bound peroxide and a solid peroxide (ii) an abrasive and (iii) a substantially anhydrous orally acceptable carrier, for example, polyethylene glycol. The bound peroxide may be hydrogen peroxide and a polymer and/or any peroxide compound and a porous cross-linked polymer, such as polymers of polyvinyl pyrrolidone, polyacrylates, a polymethacrylates, and a polyitaconates. The solid peroxide may be sodium perborate or urea peroxide. The invention also provides methods of whitening the tooth surfaces by contacting the surface with the composition.
摘要翻译： 本发明提供了一种单相增白洁齿剂，其包括（i）选自过氧化氢，结合过氧化物和固体过氧化物的增白剂（ii）研磨剂和（iii）基本上无水的口服可接受的载体，例如 ， 聚乙二醇。 结合过氧化物可以是过氧化氢和聚合物和/或任何过氧化物化合物和多孔交联聚合物，例如聚乙烯吡咯烷酮聚合物，聚丙烯酸酯，聚甲基丙烯酸酯和多赖氨酸盐。 固体过氧化物可以是过硼酸钠或过氧化脲。 本发明还提供了通过使表面与组合物接触而使牙齿表面变白的方法。
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公开(公告)号：US20120058059A1
公开(公告)日：2012-03-08
申请号：US13296282
申请日：2011-11-15
CPC分类号： A61K8/22 , A61K8/20 , A61K8/25 , A61K8/463 , A61K8/737 , A61K8/8152 , A61K8/8176 , A61K8/86 , A61K8/88 , A61K8/89 , A61Q11/00
摘要： The invention provides a single phase whitening dentifrice that includes (i) a whitening agent selected from the group consisting of hydrogen peroxide, a bound peroxide and a solid peroxide (ii) an abrasive and (iii) a substantially anhydrous orally acceptable carrier, for example, polyethylene glycol. The bound peroxide may be hydrogen peroxide and a polymer and/or any peroxide compound and a porous cross-linked polymer, such as polymers of polyvinyl pyrrolidone, polyacrylates, a polymethacrylates, and a polyitaconates. The solid peroxide may be sodium perborate or urea peroxide. The invention also provides methods of whitening the tooth surfaces by contacting the surface with the composition.
摘要翻译： 本发明提供了一种单相增白洁齿剂，其包括（i）选自过氧化氢，结合过氧化物和固体过氧化物的增白剂（ii）研磨剂和（iii）基本上无水的口服可接受的载体，例如 ， 聚乙二醇。 结合过氧化物可以是过氧化氢和聚合物和/或任何过氧化物化合物和多孔交联聚合物，例如聚乙烯吡咯烷酮聚合物，聚丙烯酸酯，聚甲基丙烯酸酯和多赖氨酸盐。 固体过氧化物可以是过硼酸钠或过氧化脲。 本发明还提供了通过使表面与组合物接触而使牙齿表面变白的方法。
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公开(公告)号：US20090092562A1
公开(公告)日：2009-04-09
申请号：US12275361
申请日：2008-11-21
CPC分类号： A61K8/04 , A61K8/25 , A61K8/8164 , A61K2800/412 , A61Q11/00
摘要： The invention includes an oral care composition that reduces and/or eliminates the perception of tooth sensitivity. The composition includes an adherent material and particles having an average particle size of about 8 microns or less. The particles are present in the composition in an amount of about 5% by weight. Also included within the scope of the invention are related methods, such as methods of occluding a dentin tubule.
摘要翻译： 本发明包括减少和/或消除牙齿敏感性感觉的口腔护理组合物。 组合物包括粘附材料和具有约8微米或更小的平均粒度的颗粒。 颗粒在组合物中的存在量为约5重量％。 也包括在本发明的范围内的是相关方法，例如封闭牙本质小管的方法。
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公开(公告)号：US20060142411A1
公开(公告)日：2006-06-29
申请号：US11025583
申请日：2004-12-29
申请人： Sayed Ibrahim , Suryakant Patel , Suman Chopra , Michael Prencipe
发明人： Sayed Ibrahim , Suryakant Patel , Suman Chopra , Michael Prencipe
摘要： A tooth whitening composition for imparting a natural white appearance to dental enamel, comprising: a whitening particulate comprising hydroxyapatite and a delivery system comprising a silicone resin and a silicone adhesive. Methods of imparting whiteness to a tooth in a mammal are also provided.
摘要翻译： 一种赋予牙釉质天然白色外观的牙齿增白组合物，包括：包含羟基磷灰石的增白颗粒和包含有机硅树脂和硅氧烷粘合剂的递送系统。 还提供了赋予哺乳动物的牙齿白度的方法。
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公开(公告)号：US20050063923A1
公开(公告)日：2005-03-24
申请号：US10915125
申请日：2004-08-10
申请人： Michael Prencipe , Suman Chopra , Michael Collins
发明人： Michael Prencipe , Suman Chopra , Michael Collins
CPC分类号： A61K8/89 , A61C19/066 , A61K8/22 , A61K8/8176 , A61K8/891 , A61K8/895 , A61Q11/00
摘要： A tooth whitening system comprising a dental tray having a surface operable to confront a tooth surface, and a tooth whitening composition comprising a whitening agent and a hydrophobic polymer carrier. The tooth whitening composition is preferably substantially non-water soluble. A tooth whitening kit is also provided using a dental tray and the tooth whitening composition comprising a whitening composition and a hydrophobic polymer carrier.
摘要翻译： 一种牙齿美白系统，其包括具有可操作以面对牙齿表面的表面的牙托盘，和包含增白剂和疏水性聚合物载体的牙齿增白组合物。 牙齿美白组合物优选基本上是非水溶性的。 还使用牙科托盘和含有美白组合物和疏水性聚合物载体的牙齿增白组合物来提供牙齿美白试剂盒。
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公开(公告)号：US20050036959A1
公开(公告)日：2005-02-17
申请号：US10641963
申请日：2003-08-15
申请人： Sayed Ibrahim , Suman Chopra , Michael Prencipe
发明人： Sayed Ibrahim , Suman Chopra , Michael Prencipe
CPC分类号： A61K8/0208 , A61K8/24 , A61K8/8176 , A61K8/891 , A61K2800/412 , A61K2800/43 , A61Q11/00
摘要： A composition for the rapid, temporary whitening of teeth comprising a combination of an adhesive material and hydroxyapatite.
摘要翻译： 一种用于牙齿快速，暂时增白的组合物，其包括粘合剂材料和羟基磷灰石的组合。
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公开(公告)号：US20050281757A1
公开(公告)日：2005-12-22
申请号：US10870848
申请日：2004-06-17
申请人： Sayed Ibrahim , Suman Chopra , Michael Prencipe
发明人： Sayed Ibrahim , Suman Chopra , Michael Prencipe
CPC分类号： A61K8/0208 , A61K8/8135 , A61K8/8176 , A61K8/8182 , A61Q11/00
摘要： A composition for delivery of an oral care substance to a dental surface upon application of the composition thereto is a flexible film comprising the oral care substance dispersed in a film-forming effective amount of a polymeric matrix having a hydrophilic component, e.g., vinylpyrrolidone (VP), and a hydrophobic component, e.g., vinyl acetate (VA), in a weight ratio selected such that the film is substantially dissolvable in saliva in a period of time effective for delivery of the oral care substance. The polymeric matrix illustratively comprises a poly(VP/VA) copolymer having a VP/VA weight ratio of about 90:10 to about 10:90.
摘要翻译： 用于将组合物施用于口腔护理物质到牙齿表面的组合物是包含分散在成膜有效量的具有亲水组分的聚合物基质例如乙烯基吡咯烷酮（VP）的柔性膜 ）和疏水组分，例如乙酸乙烯酯（VA），其选择的重量比使得该膜在有效递送口腔护理物质的时间段内基本上可溶于唾液中。 聚合物基体示例性地包含VP / VA重量比为约90:10至约10:90的聚（VP / VA）共聚物。
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