公开(公告)号：US20140127783A1

公开(公告)日：2014-05-08

申请号：US14086840

申请日：2013-11-21

Applicant: Allergan, Inc.

Inventor： Lance E. Steward ,  Sanjiv Ghanshani ,  Ester Fernandez-Salas ,  Marcella A. Gilmore ,  Joseph Francis ,  Kei Roger Aoki

IPC: C12N9/52

CPC classification number: C12N9/52 ,  A61K38/4893 ,  C07K14/33 ,  C12Y304/24069

Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.

公开(公告)号：US20130288334A1

公开(公告)日：2013-10-31

申请号：US13846364

申请日：2013-03-18

Applicant: Allergan, Inc.

Inventor： Lance E. Steward ,  Sanjiv Ghanshani ,  Ester Fernandez-Salas ,  Marcella A. Gilmore ,  Joseph Francis ,  Kei Roger Aoki

IPC: C12N9/52

CPC classification number: C12N9/52 ,  A61K38/4893 ,  C07K14/33 ,  C12Y304/24069

Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.

公开(公告)号：US20130273633A1

公开(公告)日：2013-10-17

申请号：US13846307

申请日：2013-03-18

Applicant: ALLERGAN, INC.

Inventor： Lance E. Steward ,  Sanjiv Ghanshani ,  Ester Fernandez-Salas ,  Marcella A. Gilmore ,  Joseph Francis ,  Kei Roger Aoki

IPC: C12N9/52

CPC classification number: C12N9/52 ,  A61K38/4893 ,  C07K14/33 ,  C12Y304/24069

Abstract: The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.

公开(公告)号：US20130230502A1

公开(公告)日：2013-09-05

申请号：US13682398

申请日：2012-11-20

Applicant: ALLERGAN, INC.

Inventor： Birgitte P.S. Jacky ,  Patton E. Garay ,  Yanira Molina ,  Dean G. Stathakis ,  Joseph Francis ,  Kei Roger Aoki ,  Ester Fernandez-Salas

IPC: A61K38/43

CPC classification number: A61K38/43 ,  A61K38/4893 ,  C07K14/33 ,  C07K2319/00

Abstract: The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating cancer in a mammal using such TVEMP compositions.

Abstract translation: 本说明书公开了TVEMP，包含这样的TVEMP的组合物和使用这种TVEMP组合物治疗哺乳动物癌症的方法。