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39 条记录 (耗时 0.043 秒)

    Melanin Concentrating Hormone Receptor Ligands: Substituted Tetrahydroisoquinoline Analogues
    32.
    发明申请
    Melanin Concentrating Hormone Receptor Ligands: Substituted Tetrahydroisoquinoline Analogues 审中-公开
    黑色素浓度激素受体配体：取代的四氢异喹啉类似物

    公开(公告)号：US20080161344A1

    公开(公告)日：2008-07-03

    申请号：US10597641

    申请日：2005-02-09

    申请人： Cheryl K. Steenstra ,  Taeyoung Yoon ,  John M. Peterson

    发明人： Cheryl K. Steenstra ,  Taeyoung Yoon ,  John M. Peterson

    IPC分类号： A61K31/472 ,  C07D217/20 ,  C07D401/02

    CPC分类号： C07D217/06 ,  C07D217/04 ,  C07D217/22 ,  C07D217/24 ,  C07D401/06 ,  C07D491/04

    摘要： Melanin concentrating hormone receptor ligands (especially substituted tetrahydroisoquinoline analogues), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).

    摘要翻译： 提供能够调节MCH受体活性的黑色素浓缩激素受体配体（特别是取代的四氢异喹啉类似物）。 这样的配体可用于在体内或体外调节MCH与MCH受体的结合，并且特别可用于治疗人，驯养的伴侣动物和家畜中的各种代谢，喂养和性障碍。 还提供了用于治疗这种病症的药物组合物和方法，以及使用这些配体检测MCH受体的方法（例如受体定位研究）。

    Certain isoquinolinamine and phthalazinamine derivatives: corticotropin-releasing factor receptor CRF1 specific ligands
    38.
    发明授权
    Certain isoquinolinamine and phthalazinamine derivatives: corticotropin-releasing factor receptor CRF1 specific ligands 失效
    某些异喹啉胺和酞嗪胺衍生物：促肾上腺皮质激素释放因子受体CRF1特异性配体

    公开(公告)号：US06440969B2

    公开(公告)日：2002-08-27

    申请号：US09852991

    申请日：2001-05-10

    申请人： Jun Yuan ,  Taeyoung Yoon

    发明人： Jun Yuan ,  Taeyoung Yoon

    IPC分类号： C07D23730

    CPC分类号： C07D401/12 ,  C07D217/22 ,  C07D237/34

    摘要： Disclosed are compounds that are highly selective partial agonists or antagonists at human CRF1 receptors that are useful in the diagnosis and treatment of treating stress related disorders such as post traumatic stress disorder (PTSD) as well as depression, headache and anxiety. The compounds have the formula or the pharmaceutically acceptable salts thereof wherein Ar, R1, R2, R3, R4 and W are various organic and inorganic substituents.

    摘要翻译： 公开了在人CRF1受体上是高选择性部分激动剂或拮抗剂的化合物，其可用于治疗应激相关疾病如创伤后应激障碍（PTSD）以及抑郁症，头痛和焦虑症的诊断和治疗。 所述化合物具有其药学上可接受的盐，其中Ar，R 1，R 2，R 3，R 4和W是各种有机和无机取代基。

    Pyrido[2,3-b]indolizine derivatives and aza analogues thereof: CRF1 specific ligands
    39.
    发明授权
    Pyrido[2,3-b]indolizine derivatives and aza analogues thereof: CRF1 specific ligands 失效
    吡啶并[2,3-b]中氮茚衍生物及其氮杂类似物：CRF1特异性配体

    公开(公告)号：US06194574B1

    公开(公告)日：2001-02-27

    申请号：US09328179

    申请日：1999-06-08

    申请人： Taeyoung Yoon

    发明人： Taeyoung Yoon

    IPC分类号： C07D47114

    CPC分类号： C07D241/12 ,  C07D213/57 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04

    摘要： Disclosed are compounds of the formula: wherein Ar, R1, R2, R3, W, X, Y, and Z are substituents as defined herein, which compounds are highly selective partial agonists or antagonists at human CRF1 receptors and are useful in the diagnosis and treatment of treating stress related disorders such as post traumatic stress disorder (PTSD) as well as depression, headache and anxiety.

    摘要翻译： 公开了下式的化合物：其中Ar，R 1，R 2，R 3，W，X，Y和Z是如本文所定义的取代基，该化合物是人CRF1受体的高选择性部分激动剂或拮抗剂，并且可用于诊断和 治疗紧张相关疾病如创伤后应激障碍（PTSD）以及抑郁，头痛和焦虑。