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公开(公告)号:US09000186B2
公开(公告)日:2015-04-07
申请号:US13983248
申请日:2012-02-01
申请人: Takashi Sawada , Tomohiro Danjo , Keiichi Motosawa , Takayuki Furuta , Maki Ichioka , Masamori Sugawara , Noriaki Uesaka
发明人: Takashi Sawada , Tomohiro Danjo , Keiichi Motosawa , Takayuki Furuta , Maki Ichioka , Masamori Sugawara , Noriaki Uesaka
IPC分类号: C07D235/02 , C07D471/04 , A61K31/4184 , A61K31/42 , A61K31/4355 , A61K31/4439 , A61K31/4525 , A61K31/497 , A61K31/519 , C07D487/04 , C07D519/00
CPC分类号: C07D471/04 , A61K31/4184 , A61K31/42 , A61K31/4355 , A61K31/4439 , A61K31/4525 , A61K31/497 , A61K31/519 , C07D487/04 , C07D519/00
摘要: A ring-fused heterocyclic derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof having a T-type calcium channel regulatory effect and useful as a pruritus therapeutic and/or preventive agent, and the like are provided. In the general formula (I), R1 represents optionally substituted lower alkyl, and the like; R2 represents an optionally substituted cycloalkyl, and the like; Q represents a hydrogen atom, and the like; R3 represents —C(═O)NR8R9 (wherein R8 and R9 may be the same or different, and each represents a hydrogen atom, and the like), and the like; L1 represents —CR11AR11B— (wherein R11A and R11B may be the same or different, and each represents a hydrogen atom, and the like), and the like; and W1 and W2 may be the same or different, and each represents C—R12 (wherein R12 represents a hydrogen atom, and the like), and the like.
摘要翻译: 提供由具有T型钙通道调节作用并可用作瘙痒治疗和/或预防剂的由以下通式(I)表示的环稠合杂环衍生物或其药学上可接受的盐。 在通式(I)中,R 1表示任选取代的低级烷基等; R2表示任选取代的环烷基等; Q表示氢原子等; R 3表示-C(= O)NR 8 R 9(其中R 8和R 9可以相同或不同,各自表示氢原子等)等。 L1表示-CR11AR11B-(其中R11A和R11B可以相同或不同,各自表示氢原子等)等。 并且W1和W2可以相同或不同,并且各自表示C-R12(其中R12表示氢原子等)等。