公开(公告)号：US20180355416A1

公开(公告)日：2018-12-13

申请号：US15989100

申请日：2018-05-24

Applicant: The Regents of the University of California ,  Ludwig Institute for Cancer Research Ltd

Inventor： Paul Mischel ,  Prashant Mali ,  Vineet Bafna ,  Kristen Turner ,  Viraj Deshpande ,  Doruk Beyter

IPC: C12Q1/6841

CPC classification number: C12Q1/6841

Abstract: Provided herein are, inter alia, methods and compositions to detect, monitor and treat cancer, wherein the cancer includes amplified extrachromosomal oncogenes. The methods are useful for personalized treatment and exploit differential expression of amplified extrachromosomal oncogenes in cancer cells versus healthy cells.