摘要:
The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要:
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
摘要:
The present invention provides compounds of Formula I: wherein R1, R2, R3, and X are as defined herein. The compounds of Formula (I) and pharmaceutical compositions thereof are useful for the treatment of cancer, and B-Raf-associated diseases.
摘要:
A medically implantable electrical connector includes a housing having a bore with an internal V-groove or a flat bottom groove therein along with radial garter spring disposed in the V-groove or an axial garter spring disposed in the flat bottom groove. A pin is provided and sized for insertion in the housing bore. The housing, spring and pin are formed from a combination of medically implantable materials in order to control electrical resistivity between the housing, the garter spring and the pin.
摘要:
A protective case for a portable device having a touch screen is constructed from a back frame, a front frame and a stretchable cover. The back frame receives the portable device through an open front and the stretchable cover is stretched over the back frame and the device. A portion of the cover stretches over the back frame and portable device such that the portable device is securely held in the back frame and the touch screen can be accessed and used when the device is mounted in the back frame and stretchable cover. A front frame with a transparent screen protector that allows the touch screen of the portable device to be used while the device is fully enclosed in the case is removably coupled to the back frame with grasping arms that connect to mounting portions on the back frame that extend through openings in the stretchable cover. A debris resistant seal is created between the front frame and the stretchable cover through a compression fit.
摘要:
The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要:
The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.
摘要:
A connector assembly is provided for connecting two planar surfaces or structures together to permit electrical transmission between the two. As described, the connector have at least two housing sections having grooves formed therein for receiving springs, such as canted coil springs. The springs are configured to provide constant mechanical and electrical connection between multiple parts and allow for small motions between such parts. By allowing for movement of the connected parts, adequate connection during thermal changes and/or vibrations is maintained. This is possible due to the spring contact interface between the connector assembly and the connecting parts, which allows relative movement between the springs and the connecting parts.