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31.发明授权Method and compositions using (+) norcisapride in combination with proton pump inhibitors or H2 receptor antagonist 失效使用（+）诺西沙必利与质子泵抑制剂或H2受体拮抗剂组合的方法和组合物公开(公告)号：US06353005B1
公开(公告)日：2002-03-05
申请号：US09507965
申请日：2000-02-22
Applicant: Paul D. Rubin , Timothy J. Barberich
Inventor： Paul D. Rubin , Timothy J. Barberich
IPC: A61K31445
CPC classification number: A61K31/135 , A61K31/415 , A61K31/445 , A61K38/16 , A61K45/06 , A61K2300/00
Abstract: The invention relates to methods and compositions for the prevention, treatment, or management of gastrointestinal disorders or symptoms thereof, employing two or more agents or compounds to provide a triple site action on 5-HT3 receptors, 5-HT4 receptors, and at least one of H2 receptors and proton pumps.
Abstract translation: 本发明涉及用于预防，治疗或管理胃肠道疾病或其症状的方法和组合物，其采用两种或多种药剂或化合物来提供对5-HT 3受体，5-HT 4受体和至少一种 的H2受体和质子泵。
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32.发明授权Method for inducing bronchodilation using optically pure R(-) albuterol 失效使用光学纯的R（ - ）沙丁胺醇诱导支气管扩张的方法
公开(公告)号：US5844002A
公开(公告)日：1998-12-01
申请号：US63551
申请日：1998-04-21
Applicant: Timothy J. Barberich , James W. Young
Inventor： Timothy J. Barberich , James W. Young
IPC: A61K31/135 , A61K31/137
CPC classification number: A61K31/137 , A61K31/135 , Y10S514/826
Abstract: The optically pure R(-) isomer of albuterol, which is substantially free of the S(+) isomer, is a potent bronchodilator for relieving the symptoms associated with asthma in individuals. A method is disclosed utilizing the optically pure R(-) isomer of albuterol for treating asthma while minimizing the side effects associated with albuterol.
Abstract translation: 基本上不含S（+）异构体的沙丁胺醇的光学纯的R（ - ）异构体是一种有效的支气管扩张剂，用于缓解个体与哮喘相关的症状。 公开了利用沙丁胺醇的光学纯的R（ - ）异构体治疗哮喘，同时最小化与沙丁胺醇相关的副作用的方法。
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公开(公告)号：US5362755A
公开(公告)日：1994-11-08
申请号：US163581
申请日：1993-12-07
Applicant: Timothy J. Barberich , James W. Young
Inventor： Timothy J. Barberich , James W. Young
IPC: A61K31/135 , A61K31/137
CPC classification number: A61K31/137 , A61K31/135 , Y10S514/826
Abstract: The optically pure R(-) isomer of albuterol, which is substantially free of the S(+) isomer, is a potent bronchodilator for relieving the symptoms associated with asthma in individuals. A method is disclosed utilizing the optically pure R(-) isomer of albuterol for treating asthma while minimizing the side effects associated with chronic administration of racemic albuterol.
Abstract translation: 基本上不含S（+）异构体的沙丁胺醇的光学纯的R（ - ）异构体是一种有效的支气管扩张剂，用于缓解个体与哮喘相关的症状。 公开了一种利用沙丁胺醇的光学纯的R（ - ）异构体治疗哮喘，同时最小化与外消旋沙丁胺醇的慢性施用相关的副作用的方法。
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34.发明授权Methods and compositions for treating depression using optically pure fluoxetine 失效使用光学纯氟西汀治疗抑郁症的方法和组合物
公开(公告)号：US5104899A
公开(公告)日：1992-04-14
申请号：US566655
申请日：1990-08-13
Applicant: James W. Young , Timothy J. Barberich
Inventor： James W. Young , Timothy J. Barberich
IPC: A61K31/135
CPC classification number: A61K31/135
Abstract: A method and composition are disclosed utilizing the pure S(+) isomer of fluoxetine, which is a potent antidepressant substantially free of adverse toxic or psychological effects, having a rapid onset of action and a high response rate.
Abstract translation: 公开了使用氟西汀的纯S（+）异构体的方法和组合物，其是具有快速起效和高反应率的基本上没有不利毒性或心理作用的强效抗抑郁药。
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