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公开(公告)号：US07728104B2
公开(公告)日：2010-06-01
申请号：US11977436
申请日：2007-10-24
摘要： Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the overall efficiency and yield of the process.
摘要翻译： 公开了制备具有含氨基侧链的糖肽膦酸酯衍生物的方法。 几个工艺步骤在单个反应容器中进行，而不分离中间反应产物，从而产生较少的废物并提高该方法的总体效率和产率。
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公开(公告)号：US20090069534A1
公开(公告)日：2009-03-12
申请号：US12082096
申请日：2008-04-08
申请人： Jyanwei Liu , Junning Lee
发明人： Jyanwei Liu , Junning Lee
IPC分类号： C07K7/64
CPC分类号： C07K9/008
摘要： Disclosed are hydrochloride salts of telavancin having a chloride ion content of from about 2.4 wt. % to about 4.8 wt. %. The disclosed salts have improved stability during storage at ambient temperatures compared to other hydrochloride salts. Also disclosed are processes for preparing such salts.
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公开(公告)号：US20080227963A1
公开(公告)日：2008-09-18
申请号：US11977436
申请日：2007-10-24
IPC分类号： C07G11/00
摘要： Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the overall efficiency and yield of the process.
摘要翻译： 公开了制备具有含氨基侧链的糖肽膦酸酯衍生物的方法。 几个工艺步骤在单个反应容器中进行，而不分离中间反应产物，从而产生较少的废物并提高该方法的总体效率和产率。
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34.发明申请公开(公告)号：US20080091034A1
公开(公告)日：2008-04-17
申请号：US11974982
申请日：2007-10-17
申请人： Mathai Mammen , David Oare , Junning Lee , Weijiang Zhang
发明人： Mathai Mammen , David Oare , Junning Lee , Weijiang Zhang
IPC分类号： C07D207/08
CPC分类号： C07D401/14
摘要： This invention provides 4-amino-1-(pyridylmethyl)piperidine and related compounds and pharmaceutically acceptable salts thereof which are useful as muscarinic receptor antagonists. This invention also provides pharmaceutical compositions containing such compounds; processes and intermediates useful for preparing such compounds; and methods for treating disease conditions mediated by muscarinic receptors, such as overactive bladder, irritable bowel syndrome and chronic obstructive pulmonary disease, using such compounds.
摘要翻译： 本发明提供了可用作毒蕈碱受体拮抗剂的4-氨基-1-（吡啶基甲基）哌啶及其相关化合物及其药学上可接受的盐。 本发明还提供含有这些化合物的药物组合物; 用于制备这些化合物的方法和中间体; 以及使用这些化合物治疗由毒蕈碱受体介导的疾病状况的方法，例如膀胱过度活动，肠易激综合征和慢性阻塞性肺疾病。
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公开(公告)号：US07301004B2
公开(公告)日：2007-11-27
申请号：US11437066
申请日：2006-05-19
IPC分类号： A61K38/14 , C07K9/0014
摘要： Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the overall efficiency and yield of the process.
摘要翻译： 公开了制备具有含氨基侧链的糖肽膦酸酯衍生物的方法。 几个工艺步骤在单个反应容器中进行，而不分离中间反应产物，从而产生较少的废物并提高该方法的总体效率和产率。
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公开(公告)号：US20060264607A1
公开(公告)日：2006-11-23
申请号：US11437066
申请日：2006-05-19
申请人： Michael Leadbetter , Martin Linsell , Junning Lee , Jyanwei Liu
发明人： Michael Leadbetter , Martin Linsell , Junning Lee , Jyanwei Liu
摘要： Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the overall efficiency and yield of the process.
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公开(公告)号：US07074890B2
公开(公告)日：2006-07-11
申请号：US10926148
申请日：2004-08-25
IPC分类号： A61K38/00
摘要： Disclosed are processes for preparing glycopeptide phosphonate derivatives having an amino-containing side chain. Several of the process steps are conducted in a single reaction vessel without isolation of intermediate reaction products, thereby generating less waste and improving the overall efficiency and yield of the process.
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公开(公告)号：US20050113561A1
公开(公告)日：2005-05-26
申请号：US10970128
申请日：2004-10-21
申请人： Jyanwei Liu , Junning Lee
发明人： Jyanwei Liu , Junning Lee
CPC分类号： C07K9/008
摘要： Disclosed are hydrochloride salts of telavancin having a chloride ion content of from about 2.4 wt. % to about 4.8 wt. %. The disclosed salts have improved stability during storage at ambient temperatures compared to other hydrochloride salts. Also disclosed are processes for preparing such salts.
摘要翻译： 公开了具有约2.4重量％的氯离子含量的特拉万宁的盐酸盐 ％至约4.8wt。 ％ 所公开的盐在与其它盐酸盐相比在环境温度下储存期间具有改善的稳定性。 还公开了制备这种盐的方法。
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