利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

47 条记录 (耗时 0.03 秒)

    4-(phenyl-(piperidin-4-yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
    34.
    发明授权
    4-(phenyl-(piperidin-4-yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders 失效
    4-（苯基 - （哌啶-4-基） - 氨基） - 苯甲酰胺衍生物及其用于治疗疼痛，焦虑或胃肠道疾病

    公开(公告)号：US07226933B2

    公开(公告)日：2007-06-05

    申请号：US10477852

    申请日：2002-05-16

    申请人： William Brown ,  Andrew Griffin ,  Christopher Walpole

    发明人： William Brown ,  Andrew Griffin ,  Christopher Walpole

    IPC分类号： C07D211/58

    CPC分类号： C07D401/06 ,  C07D211/58 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06 ,  Y02P20/55

    摘要： Compounds of general formula I R1 is selected from any one of phenyl, pyridinyl, pyrrolyl, thienyl, furanyl, imidazolyl, triazolyl, and pyridine N-oxide; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1–C6alkyl, NO2, CF3, C1–C6alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.

    摘要翻译： 通式I R 1的化合物选自苯基，吡啶基，吡咯基，噻吩基，呋喃基，咪唑基，三唑基和吡啶N-氧化物中的任一种; 其中每个R 1苯基环和R 1个杂芳族环可以任选和独立地被1,2或3个选自直链和支链C 1〜 C 1 -C 6烷基，NO 2，CF 3，C 1 -C 6烷基，C 1 -C 6烷基， 烷氧基，氯，氟，溴和碘。 苯环上和杂芳环上的取代可以在所述环体系上的任何位置进行; 在本申请中公开和要求保护，以及它们的药学上可接受的盐和药物组合物，其包含新化合物及其在治疗中的用途，特别是在治疗疼痛，焦虑和功能性胃肠疾病中的用途。

    4-(phenyl-(piperidin-4yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
    36.
    发明授权
    4-(phenyl-(piperidin-4yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders 失效
    4-（苯基 - （哌啶-4-基） - 氨基） - 苯甲酰胺衍生物及其用于治疗疼痛，焦虑或胃肠道疾病

    公开(公告)号：US07008952B2

    公开(公告)日：2006-03-07

    申请号：US10477636

    申请日：2002-05-16

    申请人： William Brown ,  Andrew Griffin ,  Christopher Walpole

    发明人： William Brown ,  Andrew Griffin ,  Christopher Walpole

    IPC分类号： A61K31/55 ,  C07D211/58

    CPC分类号： C07D401/06 ,  C07D211/58 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06

    摘要： Compounds of general formula I[Chemical formula should be inserted here. Please see paper copy] R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl and pyridine N-oxide; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1–C6alkyl, NO2, CF3, C1–C6alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.

    摘要翻译： 通式Ⅰ化合物[化学式应在此插入。 R 1选自苯基，吡啶基，噻吩基，呋喃基，咪唑基，吡咯基，三唑基，噻唑基和吡啶N-氧化物中的任何一种。 其中每个R 1苯基环和R 1个杂芳族环可以任选和独立地被1,2或3个选自直链和支链C 1〜 C 1 -C 6烷基，NO 2，CF 3，C 1 -C 6烷基，C 1 -C 6烷基， 烷氧基，氯，氟，溴和碘。 苯环上和杂芳环上的取代可以在所述环体系上的任何位置进行; 在本申请中公开和要求保护，以及包含新化合物的盐和药物组合物及其在治疗中的用途，特别是在治疗疼痛，焦虑和功能性胃肠道疾病中的用途。

    Process for the preparation diaryl-4-amino-piperidinyl compounds
    37.
    发明授权
    Process for the preparation diaryl-4-amino-piperidinyl compounds 失效
    二芳基-4-氨基 - 哌啶基化合物的制备方法

    公开(公告)号：US06835840B2

    公开(公告)日：2004-12-28

    申请号：US10433719

    申请日：2003-06-04

    申请人： Andrew Griffin

    发明人： Andrew Griffin

    IPC分类号： C07D21158

    CPC分类号： C07D211/58

    摘要： The present invention discloses a now and improved process for the preparation 1-substituted di-aryl-4-amino-piperidinyl compounds by a one-pot double arylation followed by optional deprotection step(s).

    摘要翻译： 本发明公开了通过一锅双芳基化，然后通过任选的脱保护步骤制备1-取代的二芳基-4-氨基 - 哌啶基化合物的现在和改进的方法。