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公开(公告)号：US20140011779A1
公开(公告)日：2014-01-09
申请号：US13787924
申请日：2013-03-07
申请人： Umecrine AB
IPC分类号： C07J7/00
CPC分类号： C07J7/009 , C07J1/00 , C07J1/0011 , C07J5/0015 , C07J7/00 , C07J7/002 , C07J7/0065 , C07J7/007 , C07J41/00 , C07J41/0016 , C07J41/005
摘要： Steroid compounds having increased resistance against metabolism and increased water solubility are disclosed, together with methods for their production. These substances are suitable for the manufacture of pharmaceuticals for the treatment of steroid related or steroid induced CNS disorders and for use in methods of prevention, alleviation or treatment of such disorders.
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32.发明授权公开(公告)号：US08580983B2
公开(公告)日：2013-11-12
申请号：US11943555
申请日：2007-11-20
IPC分类号： C07J5/00
CPC分类号： C07J7/009 , C07J1/00 , C07J1/0011 , C07J5/0015 , C07J7/00 , C07J7/002 , C07J7/0065 , C07J7/007 , C07J41/00 , C07J41/0016 , C07J41/005
摘要： Steroid compounds having increased resistance against metabolism and increased water solubility are disclosed, together with methods for their production. These substances are suitable for the manufacture of pharmaceuticals for the treatment of steroid related or steroid induced CNS disorders and for use in methods of prevention, alleviation or treatment of such disorders.
摘要翻译： 公开了具有增加的耐代谢性和增加的水溶性的类固醇化合物及其生产方法。 这些物质适用于制备用于治疗类固醇相关或类固醇诱导的中枢神经系统疾病的药物，并且用于预防，减轻或治疗这些疾病的方法。
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33.发明申请公开(公告)号：US20130102578A1
公开(公告)日：2013-04-25
申请号：US13716794
申请日：2012-12-17
申请人： Umecrine AB
IPC分类号： C07J1/00
CPC分类号： C07J7/009 , C07J1/00 , C07J1/0011 , C07J5/0015 , C07J7/00 , C07J7/002 , C07J7/0065 , C07J7/007 , C07J41/00 , C07J41/0016 , C07J41/005
摘要： Steroid compounds having increased resistance against metabolism and increased water solubility are disclosed, together with methods for their production. These substances are suitable for the manufacture of pharmaceuticals for the treatment of steroid related or steroid induced CNS disorders and for use in methods of prevention, alleviation or treatment of such disorders.
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公开(公告)号：US20110009442A1
公开(公告)日：2011-01-13
申请号：US12810600
申请日：2008-12-24
申请人： Brian C. Austad , Andre Lescarbeau , Lin-Chen Yu
发明人： Brian C. Austad , Andre Lescarbeau , Lin-Chen Yu
IPC分类号： A61K31/4355 , C07D221/00 , A61P35/00
CPC分类号： C07J7/009 , C07B2200/09 , C07D471/10 , C07D491/22 , C07J1/0011 , C07J5/0053 , C07J9/00 , C07J21/00 , C07J43/006 , C07J63/00 , C07J65/00 , C07J69/00 , C07J71/0005
摘要： The invention is directed to a method to reduce a C—C double bond of an enone of a steroidal compound to produce a mixture of β ketone product and α ketone product, comprising treating a solution or suspension of the steroidal compound in a solvent with hydrogen gas in the presence of a catalyst and a substituted pyridine.
摘要翻译： 本发明涉及一种降低甾族化合物的烯酮的C-C双键以产生“bgr”的混合物的方法。 酮产物和α-酮产物，包括在催化剂和取代吡啶的存在下，用氢气处理溶剂中的甾族化合物的溶液或悬浮液。
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35.发明申请NEW STEROIDS HAVING INCREASED WATER SOLUBILITY AND RESISTANCE AGAINST METABOLISM, AND METHODS FOR THEIR PRODUCTION 失效具有提高水分溶解性和抗性的新型甾体化合物及其生产方法公开(公告)号：US20080119416A1
公开(公告)日：2008-05-22
申请号：US11943555
申请日：2007-11-20
CPC分类号： C07J7/009 , C07J1/00 , C07J1/0011 , C07J5/0015 , C07J7/00 , C07J7/002 , C07J7/0065 , C07J7/007 , C07J41/00 , C07J41/0016 , C07J41/005
摘要： Steroid compounds having increased resistance against metabolism and increased water solubility are disclosed, together with methods for their production. These substances are suitable for the manufacture of pharmaceuticals for the treatment of steroid related or steroid induced CNS disorders and for use in methods of prevention, alleviation or treatment of such disorders.
摘要翻译： 公开了具有增加的耐代谢性和增加的水溶性的类固醇化合物及其生产方法。 这些物质适用于制备用于治疗类固醇相关或类固醇诱导的中枢神经系统疾病的药物，并且用于预防，减轻或治疗这些疾病的方法。
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36.发明授权17-hydroxyiminoalkyl and 17-hydroxyiminomethylalkenyl cyclopentaneperhydrophenanthrene derivatives active on the cardiovascular system, a process for their preparation and pharmaceutical compositions containing the same 失效对心血管系统有活性的17-羟基亚氨基烷基和17-羟基亚氨基甲基烯基环戊烷四氢菲衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US5792759A
公开(公告)日：1998-08-11
申请号：US648962
申请日：1996-05-17
IPC分类号： A61K31/56 , A61K31/575 , A61P9/00 , A61P43/00 , C07J7/00 , C07J9/00 , C07J41/00 , C07J43/00 , C07J75/00 , A61K31/58
CPC分类号： C07J9/00 , C07J41/0038 , C07J41/0055 , C07J43/003 , C07J7/009
摘要： Novel 17-hydroxyiminoalkyl and 17-hydroxyiminomethylalkenyl steroids of the general formula (I) ##STR1## where A, R.sup.1 and R.sup.2 are defined in the specification are disclosed. The compounds have cardiovascular activity. Pharmaceutical compositions containing compounds of formula (I) are also disclosed for the treatment of heart failure and hypertension.
摘要翻译： 公开了通式（I）的新型17-羟基亚氨基烷基和17-羟基亚氨基甲基烯基甾族化合物，其中A，R1和R2在说明书中定义。 该化合物具有心血管活性。 还公开了含有式（I）化合物的药物组合物用于治疗心力衰竭和高血压。
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公开(公告)号：US4076737A
公开(公告)日：1978-02-28
申请号：US717854
申请日：1976-08-26
申请人： Georg Anner , Charles Meystre
发明人： Georg Anner , Charles Meystre
CPC分类号： C07J13/007 , C07J7/008 , C07J7/009
摘要： The derivatives of 1-dehydro-6.alpha.,9.alpha.-difluoro-16.alpha.-methyl-corticosterone having an aldehyde group in 21-position instead of the hydroxyl group, and derivatives of such aldehydes having a 2-chlorine atom, the corresponding hydrates, as well as their functional aldehyde derivatives, such as the acetals, display an antiinflammatory and thymolytic action. They are prepared by conventional methods.
摘要翻译： 具有21位醛基而不是羟基的1-脱氢-6α，9α-二氟-16α-甲基 - 皮质酮衍生物，以及具有2-氯原子的醛的衍生物，相应的水合物 ，以及它们的官能醛衍生物，例如缩醛，显示出抗炎和胸腺的作用。 它们是通过常规方法制备的。
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公开(公告)号：US09822142B2
公开(公告)日：2017-11-21
申请号：US14399780
申请日：2013-05-06
CPC分类号： C07J7/009 , C07B2200/13 , C07J3/005 , C07J31/006 , C07J71/0005 , C07J71/0031 , Y10T428/2982
摘要： The present invention further provides method of preparing nanocrystals of a hydrophobic therapeutic agent such as fluticasone or triamcinolone, pharmaceutical compositions (e.g., topical or intranasal compositions) thereof and methods for treating and/or preventing the signs and/or symptoms of disorders such as blepharitis, meibomian gland dysfunction or skin inflammation or a respiratory disease (e.g., asthma).
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公开(公告)号：US20170247406A1
公开(公告)日：2017-08-31
申请号：US15319503
申请日：2015-06-18
CPC分类号： C07J41/005 , C07J1/0011 , C07J5/0015 , C07J7/002 , C07J7/007 , C07J7/0085 , C07J7/009 , C07J13/007 , C07J17/00 , C07J21/00 , C07J21/006 , C07J21/008
摘要： Described herein are steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein R1, R2a, R2b, R3, R4, R5a, R5b, R6, and Z are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.
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公开(公告)号：US09428541B2
公开(公告)日：2016-08-30
申请号：US14026957
申请日：2013-09-13
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , The Chancellor, Masters and Scholars of the University of Oxford
IPC分类号： A61K31/45 , A61K31/7008 , C07D211/46 , A61K31/513 , C07J43/00 , C07D211/94 , A61K31/7072 , A61K31/661 , A61K31/575 , C07D473/16 , A61K31/708 , C07J7/00 , C07H19/20 , A61K31/6615 , A61K31/197 , C07H19/06 , A61K31/675 , A61K31/445 , A61K31/40 , A61K31/5375 , A61K31/7012 , A61K31/685 , A61K31/42 , A61K31/58 , A61K31/431 , A61K31/52 , A61K31/195
CPC分类号： C07J43/003 , A61K31/195 , A61K31/197 , A61K31/40 , A61K31/42 , A61K31/431 , A61K31/445 , A61K31/513 , A61K31/52 , A61K31/5375 , A61K31/575 , A61K31/58 , A61K31/661 , A61K31/6615 , A61K31/675 , A61K31/685 , A61K31/7008 , A61K31/7012 , A61K31/7072 , A61K31/708 , C07D211/94 , C07D473/16 , C07H19/06 , C07H19/20 , C07J7/009
摘要： The present invention provides a compound which is an inhibitor of sphingolipid biosynthesis for use in the treatment of a disease which has a secondary Niemann-Pick type C disease like cellular phenotype.
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