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    METHOD AND APPARATUS FOR EFFECTING TRANSFER OF REACTION RECEPTACLES IN AN INSTRUMENT FOR MULTI-STEP ANALYTICAL PROCEDURES
    31.
    发明申请
    METHOD AND APPARATUS FOR EFFECTING TRANSFER OF REACTION RECEPTACLES IN AN INSTRUMENT FOR MULTI-STEP ANALYTICAL PROCEDURES 有权
    用于多步骤分析程序的仪器中反应接头的转移的方法和装置

    公开(公告)号：US20120128451A1

    公开(公告)日：2012-05-24

    申请号：US13320746

    申请日：2010-05-17

    申请人： Norbert D. Hagen ,  Byron J. Knight ,  David Opalsky ,  Jason F. Rhubottom ,  Olaf Hörger ,  Heiko Sayer ,  Harald Thahedl ,  Stefan Habrich

    发明人： Norbert D. Hagen ,  Byron J. Knight ,  David Opalsky ,  Jason F. Rhubottom ,  Olaf Hörger ,  Heiko Sayer ,  Harald Thahedl ,  Stefan Habrich

    IPC分类号： B65G47/00

    CPC分类号： B65G47/901 ,  G01N35/026 ,  G01N35/04 ,  G01N2035/0413 ,  G01N2035/0422 ,  G01N2035/0484

    摘要： Systems for effecting transfer of reaction receptacles between modules of an instrument for performing multi-step analytical procedures and for adjusting for variations in the positions of such modules includes a receptacle carrier supported on a track on which the carrier translates between different modules located adjacent to the track. The carrier includes a receptacle distribution head supported on a receptacle carrier carriage. The distribution head includes a receptacle moving mechanism adapted to move receptacles into and out of the distribution head and into and out of a module. The carriage is engaged with the track and adapted for translation along the track. Drive systems effect powered translation of the carriage, powered elevation and rotation of the distribution head, and powered movement of receptacles into and out of the distribution head. A transfer position locating system automatically determines a receptacle transfer position of the receptacle carrier with respect to each module.

    摘要翻译： 用于在仪器的模块之间进行反应容器的传送以用于执行多步骤分析程序并用于调整这些模块的位置变化的系统包括支撑在轨道上的插座载体，载体在载体上在不同模块之间平移， 跟踪。 托架包括支撑在插座托架上的插座分配头。 分配头包括容纳移动机构，其适于将容器移入和移出分配头并进出模块。 滑架与轨道接合并适应轨道的翻译。 驱动系统影响滑架的动力翻转，分配头的动力升降和旋转，以及插座进出分配头的动力运动。 传送位置定位系统自动确定插座托架相对于每个模块的插座传送位置。

    Apparatus for monitoring bioluminescence of biological samples
    32.
    发明授权
    Apparatus for monitoring bioluminescence of biological samples 失效
    用于监测生物样品生物发光的装置

    公开(公告)号：US07407797B2

    公开(公告)日：2008-08-05

    申请号：US10985955

    申请日：2004-11-12

    申请人： Masahiro Ishiura ,  Kazuhisa Okamoto ,  Kiyoshi Onai ,  Takayoshi Furusawa

    发明人： Masahiro Ishiura ,  Kazuhisa Okamoto ,  Kiyoshi Onai ,  Takayoshi Furusawa

    IPC分类号： C12M1/34

    CPC分类号： C12M41/36 ,  C12M23/12 ,  G01N21/13 ,  G01N21/253 ,  G01N21/763 ,  G01N35/028 ,  G01N2035/0422

    摘要： An apparatus of monitoring the bioluminescence of organism samples comprises a culture part including a plurality of plates for putting plural organism samples and capable of cultivating said plural organism samples, a monitoring part for monitoring bioluminescences of said plural organism samples, a convey means for conveying said plural plates to said monitoring part, a control part for controlling a movement of said convey means and controlling a monitoring condition of the bioluminescence of said organism sample, and a computer for record and analysis, wherein said monitoring part, control part and computer are separated from each other.

    摘要翻译： 监测生物样品的生物发光的装置包括培养部分，其包括用于放置多个生物体样品并能够培养所述多个生物体样本的多个平板，用于监测所述多个有机体样品的生物体系的监测部分， 用于控制所述传送装置的运动并控制所述生物样品的生物发光的监测条件的控制部分和用于记录和分析的计算机，其中所述监测部分，控制部分和计算机被分离 从彼此。

    Device for drug-drug interaction testing sample preparation
    33.
    发明申请
    Device for drug-drug interaction testing sample preparation 审中-公开
    药物相互作用试验样品制备装置

    公开(公告)号：US20030069699A1

    公开(公告)日：2003-04-10

    申请号：US10065544

    申请日：2002-10-29

    发明人： Sean Ekins ,  Diane Lynn Johnson ,  Kevin George Kelly

    IPC分类号： G06F019/00

    CPC分类号： C12Q1/26 ,  B01L3/50255 ,  G01N1/4077 ,  G01N33/5076 ,  G01N35/028 ,  G01N35/1074 ,  G01N2035/0422

    摘要： A method and device for the automated large scale preparation for testing of drug-drug interactions, particularly with determination of IC50 and Ki, as a screening tool enhancement for determining viability of large numbers of compounds as drug candidates. Small samples of specific probe substrates and new compound inhibitors are automatically dispensed en masse into multi-welled reaction plates which are prefilled with thawed human microsomes, buffer and cofactor. The reaction plates are incubated and the reaction products are tested within degradation time limits, for initial biological determinations of relevant interaction effects of the compounds. The device used for the preparations comprises computer controlled multiple liquid handling cannulas, micropipetting members, refrigeration, freezer and temperature controlled incubator units, vacuum filtration device, bar code tracking of the plates, transport mechanisms for movement and manipulation of multiwell plates and sample mixing elements with co-ordinated timing of all operations within limited timeframe testing parameters.

    摘要翻译： 用于测定药物 - 药物相互作用的自动化大规模制备的方法和装置，特别是通过测定IC50和Ki作为用于确定作为药物候选物的大量化合物的活力的筛选工具增强。 特定探针底物和新化合物抑制剂的小样本被自动分配到预先充满解冻的人微粒体，缓冲液和辅因子的多孔反应板中。 将反应板温育，并在降解时间限度内测试反应产物，以初步测定化合物的相互作用效应。 用于制备的装置包括计算机控制的多液体处理插管，微量移液构件，制冷，冷冻和温度控制的培养箱单元，真空过滤装置，板的条码跟踪，用于移动和操纵多孔板和样品混合元件的输送机构 在有限的时间范围内进行所有操作的协调定时测试参数。

    Method for extraction, using extraction cartridge and automated extraction processing system
    36.
    发明授权
    Method for extraction, using extraction cartridge and automated extraction processing system 失效
    提取方法，采用提取筒和自动提取处理系统

    公开(公告)号：US5658800A

    公开(公告)日：1997-08-19

    申请号：US419539

    申请日：1995-04-10

    申请人： Denis Lessard ,  John Henry Burrows

    发明人： Denis Lessard ,  John Henry Burrows

    IPC分类号： G01N1/40 ,  G01N30/00 ,  G01N30/06 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

    CPC分类号： G01N30/06 ,  G01N35/0099 ,  G01N35/026 ,  G01N1/405 ,  G01N2001/4061 ,  G01N2030/009 ,  G01N2030/062 ,  G01N2035/00752 ,  G01N2035/0422 ,  G01N2035/0491 ,  G01N2035/1025 ,  G01N35/1004 ,  Y10T29/49604 ,  Y10T436/113332 ,  Y10T436/255

    摘要： An extraction cartridge, for extracting a component from a composition, contains a packing composition including a buffer composition, diatomaceous earth and absorbent. The cartridge is made by heating each component to assure it is free from contaminants. The diatomaceous earth is sifted to obtain a particular particle size. The cartridge also includes frits and filters for holding the packing composition within the cartridge. All of the components of the cartridge are selected or processed to assure that no contaminants are leached into the sample being extracted. A processing system automatically processes a plurality of cartridges. The processing system, which is capable of continuous operation, includes a platform, a rack for holding the cartridges, sample vials and extraction tubes. A walking beam conveyor system moves the rack along the platform and a system of robotic arms automatically transfers the sample to be extracted from the sample vial to the extraction cartridge and adds a predetermined amount of solvent into the extraction cartridge. The extraction process includes adding a sample into the extraction cartridge, waiting a predetermined time, adding a predetermined amount of solvent and collecting the solvent in a collection tube. The processing system can be controlled by a computer system including a dual microprocessor.

    摘要翻译： 用于从组合物中提取组分的萃取柱含有包含缓冲组合物，硅藻土和吸收剂的包装组合物。 墨盒是通过加热每个组件来确保其没有污染物。 将硅藻土筛分以获得特定的粒度。 墨盒还包括用于将包装组合物保持在墨盒内的玻璃料和过滤器。 选择或处理墨盒的所有组件，以确保没有污染物浸出到要提取的样品中。 处理系统自动处理多个盒。 能够连续操作的处理系统包括平台，用于保持盒的支架，样品瓶和提取管。 步进梁输送系统沿着平台移动机架，并且机器人手臂系统自动将要从样品瓶抽出的样品转移到提取盒，并将预定量的溶剂添加到提取盒中。 提取过程包括将样品添加到提取盒中，等待预定时间，加入预定量的溶剂并将溶剂收集在收集管中。 处理系统可以由包括双微处理器的计算机系统来控制。

    Programmable automated inoculator/replicator
    37.
    发明授权
    Programmable automated inoculator/replicator 失效
    可编程自动化机构/更换器

    公开(公告)号：US5206171A

    公开(公告)日：1993-04-27

    申请号：US628156

    申请日：1990-12-17

    申请人： Jo-Anne Dillon ,  Kwok-Him Yeung ,  Sam S. Lightstone

    发明人： Jo-Anne Dillon ,  Kwok-Him Yeung ,  Sam S. Lightstone

    IPC分类号： C12M1/32 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

    CPC分类号： C12M23/50 ,  C12M33/04 ,  G01N35/0099 ,  G01N2035/0422 ,  G01N2035/0462 ,  G01N35/028 ,  G01N35/1065 ,  Y10S435/809

    摘要： Laboratory apparatus for performing repetitive tacks includes a table and first and second bearing ways below the table. First and second carriages are mounted on corresponding bearing ways for independent motion therealong, the second carrriage moving in a plane below and parallel to the first carriage. An independently operable transfer device moves objects between the table and a selected carriage or between the carriages, as desired, and apparatus is provided adjacent to the table for performing operations on objects located on the table or on the carriages, the transfer device, and the operating apparatus being capable of repetitive operation.

    摘要翻译： 用于执行重复打标的实验室设备包括桌子和桌子下的第一和第二轴承方式。 第一和第二托架安装在相应的轴承方式上，用于独立运动，第二托架在平面下方平行于第一托架移动。 独立可操作的传送装置根据需要在桌子和选定的托架之间或托架之间移动物体，并且在桌子附近提供设备，用于对位于桌子上的物体或托架，传送装置和 操作装置能够重复操作。

    Laboratory product transport element and path arrangement
    40.
    发明授权
    Laboratory product transport element and path arrangement 有权

    公开(公告)号：US09658239B2

    公开(公告)日：2017-05-23

    申请号：US15282599

    申请日：2016-09-30

    申请人： Beckman Coulter, Inc.

    发明人： Michael Eberhardt ,  Martin Mueller ,  Sebastian Wiessner ,  Thomas Moix ,  Guillaume Ding ,  Jurjen Zoethout

    IPC分类号： G06F7/00 ,  G01N35/04

    CPC分类号： G01N35/00584 ,  G01N35/04 ,  G01N2035/0422 ,  G01N2035/0467 ,  G01N2035/0489

    摘要： The invention concerns a laboratory product transport element for a laboratory transport system with an energy receiver and/or energy accumulator to provide drive power, at least one signal receiver to receive control signals, a control unit to generate drive signals as a function of at least one control signal obtained from the at least one signal receiver, movement devices for independent movement of the laboratory product transport element on a transfer path as a function of the drive signals of the control unit, in which the drive devices are driven by the drive power and at least one holder to hold a laboratory product being transported. The invention also concerns a laboratory transport system with at least one laboratory product transport element according to an embodiment of the invention and a transfer path arrangement. The invention also concerns methods for operation of laboratory transport systems according to an embodiment of the invention.