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134 条记录 (耗时 0.015 秒)

    Crystalline forms of modafinil
    31.
    发明申请
    Crystalline forms of modafinil 有权
    莫达非尼的结晶形式

    公开(公告)号：US20050034652A1

    公开(公告)日：2005-02-17

    申请号：US10947227

    申请日：2004-09-23

    申请人： Arina Ceausu ,  Anita Lieberman ,  Judith Aronhime

    发明人： Arina Ceausu ,  Anita Lieberman ,  Judith Aronhime

    IPC分类号： A61K20060101 ,  A61K31/165 ,  C07C20060101 ,  C07C315/02 ,  C07C315/06 ,  C07C317/44 ,  C30B7/00 ,  C30B21/02 ,  C30B28/06

    CPC分类号： C07C317/44 ,  A61K31/165 ,  C07B2200/13 ,  C07C315/02 ,  C07C315/06 ,  C30B7/00 ,  C30B29/54

    摘要： The present invention provides an improved process for preparing modafinil, whereby it may be isolated in high purity by a single crystallization. The process produces modafinil free of sulphone products of over-oxidation and other byproducts. The invention further provides new crystalline Forms II-VI of modafinil and processes for preparing them. Each of the new forms is differentiated by a unique powder X-ray diffraction pattern. The invention further provides pharmaceutical compositions containing novel modafinil Forms II-IV and VI.

    摘要翻译： 本发明提供了一种制备莫达非尼的改进方法，从而可以通过单一结晶将其高纯度地分离出来。 该方法产生不含过氧化和其他副产物的砜类产物的莫达非尼。 本发明进一步提供了莫达非尼的新的晶型II-VI及其制备方法。 每种新形式都可以通过独特的粉末X射线衍射图进行区分。 本发明进一步提供了含有新型莫达非尼形式II-IV和VI的药物组合物。

    Electrophotographic toner
    33.
    发明授权
    Electrophotographic toner 失效
    电子照相墨粉

    公开(公告)号：US5382490A

    公开(公告)日：1995-01-17

    申请号：US931705

    申请日：1992-08-18

    申请人： Shigeo Yamamura ,  Junko Yamamoto ,  Tadayuki Kiyoyanagi ,  Masaharu Nomura

    发明人： Shigeo Yamamura ,  Junko Yamamoto ,  Tadayuki Kiyoyanagi ,  Masaharu Nomura

    IPC分类号： C07C315/06 ,  C07C317/22 ,  G03G9/097 ,  G03G9/00

    CPC分类号： G03G9/09775 ,  C07C315/06

    摘要： An electrophotographic toner containing a specific compound as the charge control agent is described. The electrophotographic toner according to the present invention have a sharper distribution of charge and better moisture resistance and charge durability than those of a toner wherein a conventional charge control agent is used. Therefore it can provide an image having a very high gradation and has a very high capability of repeatedly forming an image. Since the charge control agent, as such, is essentially colorless, a colorant can freely be selected according to a hue required of a color toner and the toner is not detrimental to the hue inherent in a dye and a pigment. The charge control agent is highly safe to environment.

    摘要翻译： 描述了含有特定化合物作为电荷控制剂的电子照相调色剂。 根据本发明的电子照相调色剂具有比使用常规电荷控制剂的调色剂更高的电荷分布和更好的耐湿性和电荷耐久性。 因此，可以提供具有非常高等级的图像，并具有非常高的重复形成图像的能力。 由于电荷控制剂本来基本上是无色的，所以可以根据彩色调色剂所需的色调自由地选择着色剂，并且调色剂不会对染料和颜料中固有的色调产生不利影响。 电荷控制剂对环境高度安全。

    Purification of halogenated aromatic sulfones or ketones
    35.
    发明授权
    Purification of halogenated aromatic sulfones or ketones 失效
    卤代芳香砜或酮的纯化

    公开(公告)号：US5260489A

    公开(公告)日：1993-11-09

    申请号：US953362

    申请日：1992-09-30

    申请人： Rex L. Robsein ,  Jimmie J. Straw ,  Darryl R. Fahey

    发明人： Rex L. Robsein ,  Jimmie J. Straw ,  Darryl R. Fahey

    IPC分类号： C07C45/81 ,  C07C315/06 ,  C07C317/14 ,  C07C45/61

    CPC分类号： C07C45/81 ,  C07C315/06

    摘要： A process for purifying a halogenated aromatic sulfone or ketone compound comprises contacting the compound with a mixture containing a solvent having a normal boiling point less than about 225.degree. C. and water to form a second mixture, heating the second mixture at a temperature sufficient to substantially dissolve the halogenated compound to form a third mixture, cooling the third mixture to purify and recrystallize the compound, and recovering the purified, recrystallized compound. A second embodiment of the invention comprises repeating the purification process steps at least once to further purify the halogenated aromatic sulfone or ketone compound.

    摘要翻译： 一种用于纯化卤代芳香砜或酮化合物的方法包括使化合物与含有正常沸点小于约225℃的溶剂和水的混合物接触以形成第二混合物，将第二混合物在足以 基本上溶解卤代化合物以形成第三混合物，冷却第三混合物以纯化和重结晶化合物，并回收纯化的重结晶化合物。 本发明的第二个实施方案包括至少一次重复纯化方法步骤以进一步纯化卤代芳香砜或酮化合物。

    Process for separating dichlorodiphenylsulfone isomers
    38.
    发明授权
    Process for separating dichlorodiphenylsulfone isomers 失效
    二氯二苯砜异构体分离方法

    公开(公告)号：US4876390A

    公开(公告)日：1989-10-24

    申请号：US233706

    申请日：1988-08-19

    申请人： Beth McCulloch

    发明人： Beth McCulloch

    IPC分类号： C07C315/06 ,  C07C317/14

    CPC分类号： C07C315/06

    摘要： A process for the liquid phase adsorptive separation of 4,4'-dichlorodiphenylsulfone (4,4'-DCDPS) from crystallization residue feed mixture also containing other DCDPS isomers. The feed is contacted with an X or Y type zeolite, substituted with a cation of a Group IA or IIA metal or ammonium. The other isomers are selectively adsorbed to the substantial exclusion of 4,4'-DCDPS. The 4,4'-DCDPS is recovered in high purity by fractionating the raffinate to recover the desorbent, aliphatic alcohols having 4-8 carbon atoms either used alone or diluted with an aromatic compound.

    摘要翻译： 从含有其他DCDPS异构体的结晶残渣进料混合物中液相吸附分离4,4'-二氯二苯砜（4,4'-DCDPS）的方法。 进料与X或Y型沸石接触，被IA或IIA族金属或铵的阳离子取代。 其他异构体被选择性地吸附到4,4'-DCDPS的基本排除物上。 通过分馏残液以回收脱附剂，具有4-8个碳原子的脂族醇，单独使用或用芳族化合物稀释，可以高纯度地回收4,4'-DCDPS。

    Process for the optical resolution of racemic mixtures of .alpha.-naphthyl-propionic acids
    39.
    发明授权
    Process for the optical resolution of racemic mixtures of .alpha.-naphthyl-propionic acids 失效
    光学拆分α-萘基 - 丙酸的外消旋混合物的方法

    公开(公告)号：US4661628A

    公开(公告)日：1987-04-28

    申请号：US668301

    申请日：1984-11-05

    申请人： Vincenzo Cannata ,  Giancarlo Tamerlani

    发明人： Vincenzo Cannata ,  Giancarlo Tamerlani

    IPC分类号： C07C59/64 ,  C07B31/00 ,  C07B57/00 ,  C07C51/00 ,  C07C51/06 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C231/12 ,  C07C231/20 ,  C07C235/32 ,  C07C309/73 ,  C07C313/00 ,  C07C315/06 ,  C07C317/46 ,  C07C323/20 ,  C07C323/62 ,  C07D233/56 ,  C07C103/26 ,  C07C149/41 ,  C07D209/18 ,  C07D233/64

    CPC分类号： C07C51/06

    摘要： A new process for the optical resolution of racemic mixtures of .alpha.-naphthyl-propionic acids of formula ##STR1## This process comprises reacting a racemic mixture of a compound of formula ##STR2## with an optically active substance of formula R.sub.4 --NH.sub.2 (III), said substance being a .beta.-aminoalcohol, thus forming a pair of diastereoisomeric amides which are resolved into the single diastereoisomers by fractional crystallization. The obtained single diastereoisomeric amide is then hydrolyzed to give the desired optically active .alpha.-naphthyl-propionic acid of formula ##STR3## In the above compound I.fwdarw.III and VI, R.sub.1 is (C.sub.1-6)alkyl, R.sub.2 stands for hydrogen, halogen, mercapto, (C.sub.1-6)alkylthio, phenylthio, benzylthio, (C.sub.1-6)alkylsulfonyl, benzenesulfonyl, benzenesulfonyl substituted by halogen or (C.sub.1-4)alkyl, R.sub.3 is a reactive group and R.sub.4 is the residue of a primary or secondary alcohol.

    摘要翻译： 用于光学拆分式（I）的α-萘基 - 丙酸的外消旋混合物的新方法该方法包括将式II化合物的外消旋混合物与式R4-NH2的光学活性物质 III），所述物质是β-氨基醇，从而形成一对非对映异构体酰胺，其通过分级结晶分解成单一非对映异构体。 然后将获得的单一非对映异构体酰胺水解，得到所需的式VI的光学活性α-萘基 - 丙酸在上述化合物I> III和VI中，R 1是（C 1-6）烷基，R 2代表氢 ，卤素，巯基，（C 1-6）烷硫基，苯硫基，苄硫基，（C 1-6）烷基磺酰基，苯磺酰基，被卤素或（C 1-4）烷基取代的苯磺酰基，R 3是反应性基团，R 4是伯 或仲醇。