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168 条记录 (耗时 0.021 秒)

    Process for the preparation of enantiomerically enriched esters and alcohols
    33.
    发明授权
    Process for the preparation of enantiomerically enriched esters and alcohols 失效
    用于制备对映体富集的酯和醇的方法

    公开(公告)号：US06841691B2

    公开(公告)日：2005-01-11

    申请号：US10296840

    申请日：2001-05-21

    申请人： Gerardus Karel Maria Verzijl ,  Johannes Gerardus Vries De ,  Quirinus Bernardus Broxterman

    发明人： Gerardus Karel Maria Verzijl ,  Johannes Gerardus Vries De ,  Quirinus Bernardus Broxterman

    IPC分类号： C07B53/00 ,  C07B55/00 ,  C07C29/143 ,  C07C33/20 ,  C12P41/00 ,  C11G3/00

    CPC分类号： C12P41/004

    摘要： Method for the preparation of an enantiomerically enriched ester, in which a mixture of the enantiomers of the corresponding secondary alcohol is subjected, in the presence of an acyl donor, to an enantioselective conversion in the presence of a racemisation catalyst upon which the ester is formed and an acyl donor residue is obtained, and in which the acyl donor residue is irreversibly removed from the phase in which the enantioselective conversion takes place. Preferably the enantioselective conversion is carried out enzymatically and a transfer hydrogenation catalyst is used as racemisation catalyst.The secondary alcohol can be formed in situ from the corresponding ketone, in the presence of a hydrogen donor. It is also possible to use a mixture of the secondary alcohol and the corresponding ketone as substrate.Preferably the acyl donor is chosen so that the acyl donor residue is converted in situ into another compound and/or the acyl donor residue is removed via distillation under reduced pressure.The enantiomerically enriched esters obtained can subsequently be converted into the corresponding enantiomerically enriched alcohols, which are desirable intermediate products in the preparation of liquid crystals, agro chemicals or pharmaceuticals.

    摘要翻译： 制备对映异构体富集的酯的方法，其中将相应的仲醇的对映异构体的混合物在酰基供体的存在下在形成酯的外消旋催化剂存在下进行对映选择性转化 并且获得酰基供体残基，并且其中酰基供体残基从其中进行对映选择性转化的相不可逆地除去。 优选地，对映选择性转化酶进行酶促转移氢化催化剂作为外消旋化催化剂。仲醇可以在氢供体存在下由相应的酮原位形成。 还可以使用仲醇和相应的酮的混合物作为底物。优选地选择酰基供体，使得酰基供体残基原位转化成另一种化合物和/或通过蒸馏除去酰基供体残留物 所得到的对映异构体富集的酯可以随后转化成相应的对映异构体富集的醇，这在制备液晶，农用化学品或药物中是理想的中间产物。

    8-hydroxycymene preparation by dehydrogenation
    35.
    发明授权
    8-hydroxycymene preparation by dehydrogenation 失效
    通过脱氢制备8-羟基花青制剂

    公开(公告)号：US5313008A

    公开(公告)日：1994-05-17

    申请号：US42776

    申请日：1993-04-06

    申请人： Christopher P. Newman

    发明人： Christopher P. Newman

    IPC分类号： B01J23/44 ,  C07B61/00 ,  C07C29/00 ,  C07C33/20 ,  C07C27/00

    CPC分类号： C07C29/00 ,  C07C2101/14 ,  C07C2101/16

    摘要： The invention relates to a process for the conversion of 8-hydroxymenthenes into 8-hydroxycymenes by treating the 8-hydroxymenthenes in the vapour phase with an alkaline dehydrogenation catalyst, e.g. palladium on an alkaline support. The process is carried out above 145.degree. C. The hydroxymenthene vapour is preferably passed through the catalyst system at a pressure below 8 kPa and/or with the aid of an inert gas or vapour. Oxygen may be present as a hydrogen acceptor. The process is particularly suitable for converting 8-hydroxy-p-menth-1-ene into 8-hydroxy-p-cymene. The reaction products are of value as intermediates in the preparation of musk fragrance chemicals.

    摘要翻译： 本发明涉及一种通过用碱性脱氢催化剂处理气相中的8-羟基呫吨来转化8-羟基呫吨为8-羟基甙的方法。 钯在碱性载体上。 该方法在145℃以上进行。羟基乙烯蒸气优选通过催化剂体系在低于8kPa的压力下和/或借助惰性气体或蒸气进行。 氧可以作为氢受体存在。 该方法特别适用于将8-羟基 - 对甲烯-1-烯转化为8-羟基 - 对 - 异丙基苯。 反应产物在制备麝香香料中具有重要价值。

    Preparation of 3-arylisobutyl alcohols
    38.
    发明授权
    Preparation of 3-arylisobutyl alcohols 失效
    3-芳基异丁醇的制备

    公开(公告)号：US4987270A

    公开(公告)日：1991-01-22

    申请号：US397883

    申请日：1989-08-23

    申请人： Kaspar Bott ,  Herwig Hoffman ,  Walter Scheidmeir

    发明人： Kaspar Bott ,  Herwig Hoffman ,  Walter Scheidmeir

    IPC分类号： B01J23/04 ,  B01J31/02 ,  C07B61/00 ,  C07C29/34 ,  C07C29/44 ,  C07C33/20 ,  C07C33/34

    CPC分类号： C07C29/34 ,  C07C33/20

    摘要： 3-Arylisobutanols of the general formula I ##STR1## where R.sup.1 and R.sup.2 are each hydrogen or an alkyl or cyclo-alkyl radical of not more than 8 carbon atoms, preferably alkyl of 1 to 4 carbon atoms, are prepared by a process in which an arylcarbinol of the general formula II ##STR2## is reacted with n-propanol in the presence of a catalytic amount of an alkali metal hydroxide or an alkali metal alcoholate at from 250.degree. to 350.degree. C. in a closed reaction vessel.The process is of particular importance for the preparation of 3-arylisobutanols of the formula I, where R.sup.1 is alkyl of 1 to 4 carbon atoms and R.sup.2 is hydrogen. The p-methyl-, p-isopropyl- and p-tert-butylphenylisobutanols obtained here in very good selectivity are useful intermediates for the desirable scents jasmorange, cyclamen aldehyde and Lysmeral.RTM. (Lilial.RTM.).

    摘要翻译： 其中R 1和R 2各自为氢或不超过8个碳原子的烷基或环烷基，优选1至4个碳原子的烷基的3-芳基异丁醇通过以下步骤制备： 其中将通式II的芳基甲醇（II）与正丙醇在催化量的碱金属氢氧化物或碱金属醇化物的存在下在250-350℃下反应， 封闭的反应容器。 该方法对于制备式I的3-芳基异丁醇是特别重要的，其中R 1是1至4个碳原子的烷基且R 2是氢。 在这里以非常好的选择性获得的对甲基，对异丙基和对叔丁基苯基异丁醇是所需香料茉莉，仙客来醛和Lysmeral TM（Lilial TM）的有用中间体。