公开(公告)号：US20060100233A1

公开(公告)日：2006-05-11

申请号：US10522254

申请日：2003-07-01

Applicant: Manuela Villa ,  Francesca Abrate ,  Daniele Fancelli ,  Mario Varasi ,  Anna Vulpetti

Inventor： Manuela Villa ,  Francesca Abrate ,  Daniele Fancelli ,  Mario Varasi ,  Anna Vulpetti

IPC: A61K31/4745 ,  C07D471/02

CPC classification number: C07D471/04

Abstract: The present invention provides a method for treating diseases caused by and/or associated with an altered protein kinase activity which comprises administering to a mammal in need thereof an effective amount of a pyrazole-tetrahydro pyridine derivative. The invention also provides specific pyrazole-tetrahydro pyridines, a library comprising at least two of them, a process for their preparation and the pharmaceutical compositions containing them, which are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, viral infections, autoimmune diseases and neurodegenerative disorders.

Abstract translation: 本发明提供了治疗由变化的蛋白激酶活性引起和/或与其相关的疾病的方法，其包括向有需要的哺乳动物施用有效量的吡唑 - 四氢吡啶衍生物。 本发明还提供特异性的吡唑 - 四氢吡啶，其中包含其中至少两个的文库，其制备方法和含有它们的药物组合物，其可用于治疗由改变的蛋白激酶引起的和/或与其相关的疾病 活动如癌症，细胞增殖性疾病，病毒感染，自身免疫性疾病和神经变性疾病。