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41.发明授权
公开(公告)号：US3845035A
公开(公告)日：1974-10-29
申请号：US27109872
申请日：1972-07-12
CPC分类号： C07H19/16
摘要： 1. N(6)-SUBSITUTED ADENOSINE COMPOUND OF THE FORMULA:
2-R1,6-((R3,R2-PHENYL)-CH2-NH-),9-(3,4-DI(HO-),5-(HO-
CH2-)-TETRAHYDROFUR-2-YL-)-9H-PURINE
WHEREIN R1 IS HYDROGEN, HALOGEN, AMINO, OR HYDROXYL; R2 IS CYANO OR HYDROXY-METHYL; AND R3 IS HYDROGEN, HALOGEN, LOWER ALKYL OR LOWER ALKOXY RADICAL; OR A PHARMACOLOGICALLY COMPATIBLE SALT THEREOF.-
公开(公告)号：US3841262A
公开(公告)日：1974-10-15
申请号：US26057972
申请日：1972-06-07
发明人： ROTHE W , SCHALK H , GROPPENBACHER G , RIECKMANN P , SCHELLHORN J
摘要： Process for coating tablet cores or the like with a film, comprising moving a plurality of tablet cores about within a container, introducing a current of gas through an outlet into said container into the body of moving tablet cores in such manner that a substantially tablet-free gas space is formed just beyond said gas outlet which is surrounded by said moving tablet cores, and spraying a suspension or solution of film-forming material into said current of gas. The process combines the best features of conventional coating processes in a rotating dragee kettle with the advantages of a fluidized bed coating operation.
摘要翻译： 用薄膜包覆片芯或类似物的方法，包括在容器内移动多个片芯，将气流通过出口进入所述容器进入移动片芯的主体， 在所述气体出口的正上方形成游离气体空间，所述气体出口由所述移动的片芯围绕，并且将成膜材料的悬浮液或溶液喷射到所述气体流中。 该方法结合了旋转糖衣锅中常规涂布方法的最佳特征和流化床涂层操作的优点。
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公开(公告)号：US3822285A
公开(公告)日：1974-07-02
申请号：US32620573
申请日：1973-01-24
发明人： WERNER W , VOGEL P , TIEDEMANN H , GUTHLEIN W
IPC分类号： C07D209/88 , C12Q1/54 , C07D27/68
CPC分类号： C07D209/88 , C12Q1/54
摘要： 9 -(Y - AMINOPROPYL) - 3 - AMINOCARBAZOLE, WHEN INCORPORATED INTO INDICATOR COMPOSITIONS ALSO COMPRISING OXIDATION INDICATORS SUCH AS O-TOLIDINE FOR THE ENZYMATIC DETECTION OF GLUCOSE, RESULTS IN OUTSTANDINLY STABLE INDICATOR COMPOSITIONS AND NOT ADVERSELY EFFECTED BY NORMALLY INTERFERING COMPONENTS IN THE TEST SAMPLE.
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公开(公告)号：US3806416A
公开(公告)日：1974-04-23
申请号：US24958972
申请日：1972-05-02
发明人： MOLLERING H , BEAUCAMP K , NELBOECK HOCHSTETTER M , BERGMEYER H
CPC分类号： C12Q1/34 , C12N9/78 , C12N9/86 , C12Q1/50 , G01N2333/9123 , G01N2333/978 , G01N2333/986 , Y10S435/815 , Y10S435/816 , Y10S435/824 , Y10S435/829 , Y10S435/933
摘要： CREATININE AMIDOHYDROLASE AND CREATINE AMIDINOHYDROLASE ARE PREPARED BY A PROCESS COMPRISING CULTURING A MICROORGANISM IN A CREATININE-CONTAINING MEDIUM, DIGESTING SAME, OBTAINING THE CREATININE AMIDOHYDROLASE IN SUBSTANTIALLY PURE FORM FROM THE WATER-SOLUBLE DIGESTION FRACTION AND, OPTIONALLY SEPARATING BY ION EXCHANGE CHROMATOGRAPHY ANY CREATINE AMIDINOHYDROLASE PRESENT
摘要翻译： 肌酸酐通过使用新的酶，肌酸酐酰胺水解酶来确定，肌酸酐酰胺水解酶将含肌酸酐样品中的肌酸酐转化为肌酸，后者以常规方式作为肌酸酐原始存在的量度测定。 该酶将肌酸酐转化为肌酸的能力也可用于监测浓缩过程对收集酶的功效，通过对该过程的每个步骤的产物进行取样，并确定其将加入其中的肌酸酐转化为肌酸的能力，如 这种产品中存在的酶的活性的量度。
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公开(公告)号：US3803125A
公开(公告)日：1974-04-09
申请号：US12491871
申请日：1971-03-16
发明人： WEIMANN G , BERGMEYER H , HAID E
CPC分类号： C07H1/02
摘要： NUCLEOSIDE DIPHOSPHATE AND ITS ESTERS ARE PREPARED IN GOOD YIELD, WITH SHORT REACTION TIMES AND WITHOUT SUBSTANTIAL FORMATION OF BY-PRODUCTS, BY REACTING (A) A NUCLEOSIDE MONOPHOSPHATE AMIDATE COMPOUND OF THE FORMULA:
X-O-PO2-1-AM
IN WHICH X IS NUCLEOSIDE RESIDUE, AND AM IS A RADICAL OF THE FORMULA:
-N(-R1)-R2
WHEREIN R1 AND R2, WHICH CAN BE THE SAME OR DIFFERENT ARE HYDROGEN ATOMS OR ALKYL RADICALS CONTAINING UP TO 4 CARBON ATOMS OR WHEREIN R1 AND R2, TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED, FORM A HETEROCYCLIC RING, WHICH CAN CONTAIN A FURTHER HETEROATOM; (B) A PHOSPHORIC ACID COMPOUND OF THE FORMULA:
O3P2- -O-R
IN WHICH R IS HYDROGEN ATOM OR THE RESIDUE OF A HYDROXYL GROUP-CONTAINING ORGANIC COMPOUND; IN AN ALIPHATIC ALCOHOL OF FROM 1 TO 4 CARBON ATOMS OR IN A DIALKYL KETONE OF FROM 1 TO 3 CARBON ATOMS PER ALKYL GROUP OR IN DIMETHYL FORMAMIDE, AT A PH OF FROM ABOUT 1 TO 6.5.-
公开(公告)号：US3787392A
公开(公告)日：1974-01-22
申请号：US3787392D
申请日：1971-11-26
发明人： BERGMEYER H , HAID E , NELBOECK HOCHSTETTER M , WEIMANN G
IPC分类号： C07H19/10 , C07H1/02 , C07H19/207 , C07D51/50
CPC分类号： C07H1/02
摘要： NUCLEOSIDE DIPHOSPHATE ESTERS ARE PREAPRED BY REACTING A NUCLEOSIDE MONOPHOSPHATE WITH A PHOSPHORIC ACID ESTER IN THE PRESENCE OF DICYCLOHEXYL CARBODIMIDE, WHEREIN A METHANOL SOLUTION OF A NUCELOSIDE MONOPHOSPHORIC ACID AND DICYCLOHEXYL CARBODIMIDE IS SLOWLY BROUGHT TOGETHER WITH A 1 TO 6.5 PH METHANOL SOLUTION OF A PHOSPHORIC ACID ESTER.
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47.发明授权Process for the chromatographic separation of multi-component mixtures containing glucose 失效含有葡萄糖的多组分混合物的色谱分离方法
公开(公告)号：US3785864A
公开(公告)日：1974-01-15
申请号：US15298071
申请日：1971-06-14
CPC分类号： C13K11/00 , B01D15/1871 , C13B20/12 , C13K1/08
摘要： Multi-component mixtures are chromatographically separated into their components on a large scale by using a separation column divided into two sections, passing the feed stream into the first section, removing the fractions containing impurities from the end of the first section, simultaneously passing an equivalent amount of elution agent into the second section, thereupon connecting the two column sections with each other until there appears at the end of the first section the fraction containing impurities from the next cycle of feed passed into the first section, and recovering the separated main components at the end of the second section.
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公开(公告)号：US3775253A
公开(公告)日：1973-11-27
申请号：US3775253D
申请日：1972-06-15
发明人： JAWOREK D , GRUBER W , BERGMEYER H
IPC分类号： C08F220/00 , A61K39/44 , C08F8/00 , C08F20/52 , C08F20/56 , C08F22/00 , C08F220/04 , C08G81/00 , C08G81/02 , C12N11/08 , G01N33/545 , C07G7/00 , C07G7/02
CPC分类号： C12N11/08 , A61K39/44 , C08F8/00 , C08F20/56 , C08F22/00 , Y10S530/815 , Y10S530/816 , C08F220/56 , C08F222/00
摘要： Water insoluble biologically active proteins are bound on novel copolymers consisting of (a) acrylamide (b) ethylene-maleic acid or its anhydride and/or (c) maleic acid and/or its anhydride and (d) N,N''-methylene-bis-acrylamide or ethylene diacrylate in a weight ratio a:b:c:d of 3 : 0.5 - 1.5 : 0.05 - 4 : 0.075 - 0.9, the weight ratio a : (b + c) being not more than 4, to provide compositions which are outstanding in their ability to yield up the bound protein, and with which precise substrate reactions can be carried out.
摘要翻译： 水不溶性生物活性蛋白质结合在由（a）丙烯酰胺（b）乙烯 - 马来酸或其酸酐和/或（c）马来酸和/或其酸酐和（d）N，N'-亚甲基 - 双丙烯酰胺或乙烯二丙烯酸酯的重量比a:b:c:d为3:0.5-1.5:0.05-4:0.075-0.9，重量比a:（b + c）不大于4，以提供 在产生结合蛋白的能力方面是突出的，并且可以进行精确的底物反应的组合物。
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49.发明授权
公开(公告)号：US3762609A
公开(公告)日：1973-10-02
申请号：US3762609D
申请日：1972-06-12
发明人： HAGEN A , MEWES D , GRUBER W , BERGMEYER H
CPC分类号： G01N35/1097 , G05D11/001 , G05D11/003
摘要： A sample to be analyzed is injected into a stream of carrier liquid by coupled dual valves in two branches of the stream. One of the two valves is open and the other closed at any one time. The bore of the closed valve provides a metering cavity which is filled with the sample to be analyzed, and the sample is injected by simultaneously closing the previously open valve and opening the sample-bearing closed valve. The specific, dual valve arrangement disclosed has a single movable disc arranged between two stationary discs, the discs being provided with passages filled and emptied in the necessary sequence when the movable disc is rotated.
摘要翻译： 待分析的样品通过在流的两个分支中的耦合双阀注入载液流中。 两个阀门中的一个是打开的，另一个在任何一个时间都关闭。 关闭阀的孔提供了一个填充有待分析样品的计量腔，并且通过同时关闭先前打开的阀并打开带样本的封闭阀注入样品。 所公开的具体的双阀装置具有设置在两个固定盘之间的单个可移动盘，当可移动盘旋转时，盘设置有以必要顺序填充和排空的通道。
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50.发明授权Diagnostic agent for the detection of nitrite and of nitrite-forming bacteria 失效用于检测硝酸盐和硝酸盐形成细菌的诊断试剂
公开(公告)号：US3712853A
公开(公告)日：1973-01-23
申请号：US3712853D
申请日：1970-07-15
发明人： RITTERSDORF W , RAY H , RIECKMANN P
IPC分类号： G01N33/493 , C12Q1/12 , G01N33/84 , C12K1/04
CPC分类号： C12Q1/12 , G01N33/84 , Y10S435/805
摘要： NITRITIES, E.G., NITRITES FORMED BY BACTERIA IN BODY FLUIDS, ARE DETECTED EVEN IN VERY SMALL CONCENTRATIONS, WITH A DIAGNOSTIC TEST REAGENT COMPRISING A DIAZOTIZABLE AMINE. A SOLID ORGANIC ACID, AND A COUPLING COMPONENT OF THE FORMULA
1-R,R''-1,2,3,4-TETRAHYDRO-BENZO(H)QUINOLINE
WHEREIN R IS HYDROGEN OR ALKYL, PREFERABLY LOWER ALKYL, AND R'' IS HYDROGEN, HYDROXYL OR ALKYL, PREFERABLY LOWER ALKYL, OR ACYLOXY, PREFERABLY LOWER ACYLOXY.
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