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    Pharmaceutical Formulation
    43.
    发明申请
    Pharmaceutical Formulation 审中-公开
    药物配方

    公开(公告)号：US20160228386A1

    公开(公告)日：2016-08-11

    申请号：US15133062

    申请日：2016-04-19

    申请人： Reckitt Benckiser LLC

    发明人： Nils Ahlgren ,  Mark Nuttall ,  Jeannie Wong ,  Venkatesh Balasubramanian ,  Craig Belongie ,  Ashfaq Khan ,  Neil Campbell Muir

    IPC分类号： A61K31/09 ,  A61K9/20 ,  A61K9/48 ,  A61K9/50 ,  A61K31/485 ,  A61K9/24

    CPC分类号： A61K31/09 ,  A61K9/20 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/209 ,  A61K9/4808 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5047 ,  A61K31/137 ,  A61K31/485 ,  A61K45/06 ,  A61K2300/00

    摘要： A pharmaceutical composition in the form of a tablet including a first portion and a second portion, wherein the first portion includes guaifenesin having an immediate release profile and a second drug having a sustained release profile, and wherein the second portion includes guaifenesin having a sustained release profile. The second drug can be in the form of a drug-resin complex. The second drug can be either an anti-tussive or a decongestant. The drug-resin complex includes a drug complexed to an ion exchange resin. The ion exchange resin can be a polystyrene sulfonate resin, polacrilex resin, polacrilin potassium, cholestyramine resin, or a colestyramine resin. The drug-resin complex can be provided with a coating, the coating thickness being selected to obtain the desired release profile. The drug-resin complex can be provided with a coating level of from 5% to 50%. The coating level can be from 10% to 35%.

    摘要翻译： 一种片剂形式的药物组合物，包括第一部分和第二部分，其中第一部分包括立即释放曲线的愈创甘油醚和具有持续释放曲线的第二药物，其中第二部分包括具有持续释放的愈创甘油醚 个人资料 第二种药物可以是药物 - 树脂复合物的形式。 第二种药物可以是抗咳嗽或减充血剂。 药物 - 树脂复合物包括与离子交换树脂络合的药物。 离子交换树脂可以是聚苯乙烯磺酸酯树脂，聚乙烯树脂，聚丙烯酸钾，考来烯胺树脂或考来烯胺树脂。 药物 - 树脂复合物可以设置有涂层，选择涂层厚度以获得所需的释放曲线。 药物 - 树脂复合物可以具有5％至50％的包衣水平。 涂层水平可以为10％至35％。

    Dispensing Containers for Wipe Articles
    50.
    发明申请
    Dispensing Containers for Wipe Articles 有权
    分配容器擦拭物品

    公开(公告)号：US20140367400A1

    公开(公告)日：2014-12-18

    申请号：US14357298

    申请日：2012-11-20

    申请人： Reckitt Benckiser LLC

    发明人： Andrew Dennis Crudge ,  Jesse Del Gigante ,  Christopher Michael Evans ,  Christopher Leonard Padain

    IPC分类号： A47K10/38

    CPC分类号： A47K10/38 ,  A47K10/3818 ,  A47K2010/3266 ,  B65D47/0804 ,  B65D83/0805

    摘要： Disclosed is a dispensing cap adapted to be removably, or permanently affixed to a container which container contains a plurality of individual wipes interconnected to one another but separable along one or more perforations between individual wipes, which dispensing cap includes a partly stationary and partly moveable plate having a dispensing orifice which is offset from the center part of the dispensing cap, said dispensing orifice being surrounded by a plurality of individual flexible lobes, a portion of the dispensing orifice being defined by the stationary plate part, a further portion of the dispensing orifice being defined by a moveable hinged plate part of the dispensing orifice which is moveable along a hinge line from which the hinged plate part depends from a part of the stationary plate, and further wherein the hinged plate part includes a depending brace wall which extends downwardly from the hinged plate part from the underside thereof, which brace wall is located at or near the periphery of the said remaining portion of the dispensing orifice present on the hinged plate part.

    摘要翻译： 公开了一种分配帽，其适于可移除地或永久地固定到容器，该容器包含彼此互连的但可沿着单个擦拭物之间的一个或多个穿孔分开的多个单独的擦拭物，所述分配帽包括部分固定的和部分可移动的板 具有从所述分配帽的中心部分偏移的分配孔，所述分配孔由多个单独的柔性瓣包围，所述分配孔的一部分由所述固定板部分限定，所述分配孔的另一部分 由分配孔的可移动的铰链板部分限定，该铰链板部分可沿着铰链线移动，铰链板部分从该铰链线从固定板的一部分从该铰链线移动，并且其中铰链板部分包括从 铰链板部分从其下侧，该支撑壁位于或 靠近存在于铰链板部分上的分配孔的所述剩余部分的周边。