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    System and method for X-ray generation by inverse compton scattering
    41.
    发明授权
    System and method for X-ray generation by inverse compton scattering 失效
    通过反向柯顿散射产生X射线的系统和方法

    公开(公告)号：US07310408B2

    公开(公告)日：2007-12-18

    申请号：US11096488

    申请日：2005-03-31

    申请人： Robert John Filkins ,  John Scott Price ,  Brian Lee Lawrence ,  Matthew Christian Nielsen ,  Joseph John Manak ,  Bruce Matthew Dunham

    发明人： Robert John Filkins ,  John Scott Price ,  Brian Lee Lawrence ,  Matthew Christian Nielsen ,  Joseph John Manak ,  Bruce Matthew Dunham

    IPC分类号： H05G2/00

    CPC分类号： H05G2/00

    摘要： A system for generating a tunable X-ray pulse comprises a first electron beam source configured to direct a first electron pulse of predetermined energy and pulse length towards a first interaction zone, a laser beam source configured to direct a first photon pulse of predetermined energy and pulse length towards the first interaction zone to interact with the first electron pulse. The first interaction produces a substantially monochromatic second photon pulse of higher photon energy directed towards a second interaction zone, and a second electron beam source configured to direct a second electron pulse of predetermined energy and pulse length towards the second interaction zone so that the second interaction produces an X-ray pulse of predetermined energy and pulse length in a cascaded inverse Compton scattering (ICS) configuration.

    摘要翻译： 一种用于产生可调谐X射线脉冲的系统包括：第一电子束源，被配置为将预定能量和脉冲长度的第一电子脉冲引导到第一相互作用区域，激光束源被配置为引导预定能量的第一光子脉冲;以及 脉冲长度朝向第一相互作用区域与第一电子脉冲相互作用。 所述第一相互作用产生指向第二相互作用区的较高光子能量的基本上单色的第二光子脉冲，以及被配置成将预定能量和脉冲长度的第二电子脉冲引向所述第二相互作用区域的第二电子束源， 在级联反康普顿散射（ICS）配置中产生预定能量和脉冲长度的X射线脉冲。

    Methods and systems for digitally enhancing an image of a stained material
    43.
    发明授权
    Methods and systems for digitally enhancing an image of a stained material 有权
    用于数字增强染色材料图像的方法和系统

    公开(公告)号：US08948488B2

    公开(公告)日：2015-02-03

    申请号：US12533406

    申请日：2009-07-31

    申请人： Ali Can ,  Cemal Cagatay Bilgin ,  Jens Rittscher ,  Robert John Filkins

    发明人： Ali Can ,  Cemal Cagatay Bilgin ,  Jens Rittscher ,  Robert John Filkins

    IPC分类号： G06K9/00 ,  G06T5/00

    CPC分类号： G06T5/004 ,  G06T2207/10024 ,  G06T2207/30024

    摘要： Methods and systems for digitally enhancing an initial image of a material to which a plurality of stains were previously applied, that generally comprise: unmixing the image into a plurality of individual reconstructed images, each individual image corresponding to one of the stains; estimating a residual image corresponding to the difference between the original image and the reconstructed images; adjusting one or more components of the individual images; mixing the adjusted components using one or more estimated mixing coefficients; and adding the residual image to the mixed adjusted components to generate an enhanced image.

    摘要翻译： 用于数字增强先前施加多个污渍的材料的初始图像的方法和系统，其通常包括：将图像混合成多个单独的重建图像，每个单独的图像对应于一个污渍; 估计对应于原始图像和重建图像之间的差的残差图像; 调整各个图像的一个或多个分量; 使用一个或多个估计的混合系数混合调整的组分; 并将残差图像添加到混合调整的分量以产生增强图像。

    Sequential analysis of biological samples
    44.
    发明授权
    Sequential analysis of biological samples 有权
    生物样品的顺序分析

    公开(公告)号：US08822147B2

    公开(公告)日：2014-09-02

    申请号：US13457531

    申请日：2012-04-27

    申请人： Anup Sood ,  Michael Christopher Montalto ,  Michael Gerdes ,  Maximilian Lewis Seel ,  Robert John Filkins

    发明人： Anup Sood ,  Michael Christopher Montalto ,  Michael Gerdes ,  Maximilian Lewis Seel ,  Robert John Filkins

    IPC分类号： C12Q1/68 ,  G01N33/58 ,  G01N33/542 ,  G01N33/53

    CPC分类号： G01N33/53 ,  C12Q1/68 ,  G01N33/542 ,  G01N33/582 ,  Y10T436/143333

    摘要： Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample with a second probe; physically binding the second probe to a second target; and observing a second signal from the second probe. The methods disclosed herein also provide for multiple iterations of binding, observing, signal modification for deriving information about multiple targets in a single sample. An associated kit and device are also provided.

    摘要翻译： 提供了用于检测生物样品中多个靶的方法。 所述方法包括使样品与第一探针接触; 将第一探针物理地绑定到第一靶; 观察来自第一探针的第一信号; 施用化学试剂来修饰第一信号; 使样品与第二探针接触; 将第二探针物理地绑定到第二靶上; 并观察来自第二探测器的第二信号。 本文公开的方法还提供绑定，观察，信号修改的多次迭代，用于导出关于单个样本中的多个目标的信息。 还提供了相关的套件和设备。

    Method and apparatus for ultraviolet scan planning
    46.
    发明授权
    Method and apparatus for ultraviolet scan planning 有权
    紫外线扫描计划的方法和装置

    公开(公告)号：US08063385B2

    公开(公告)日：2011-11-22

    申请号：US12474306

    申请日：2009-05-29

    申请人： Robert John Filkins ,  Robert William Tait ,  Kevin Bernard Kenny ,  Christina Chirappuram Royce

    发明人： Robert John Filkins ,  Robert William Tait ,  Kevin Bernard Kenny ,  Christina Chirappuram Royce

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6452 ,  G01N21/6458 ,  G01N21/6486 ,  G02B21/16 ,  G02B2207/113

    摘要： The invention provides method for locating one or more substantially circular-shaped tissue sample positioned on a solid support. The method involves the steps of transmitting light of a preselected wavelength onto a tissue sample, wherein the light induces the tissue sample to autofluoresce, identifying the center location of the tissue sample using the autofluoresced light, correlating the coordinates of the center location of the tissue sample on the solid support using an x, y-coordinate system, and mapping the coordinates of the tissue sample on the solid support to differentiate tissue sample containing regions from blank regions on the solid support. In a second aspect, the invention provides an apparatus for locating one or more substantially circular-shaped tissue sample positioned on a solid support.

    摘要翻译： 本发明提供了一种用于定位位于固体支持体上的一个或多个基本圆形的组织样本的方法。 该方法包括以下步骤：将预选波长的光透射到组织样本上，其中光诱导组织样本自发荧光，使用自发荧光识别组织样本的中心位置，将组织的中心位置的坐标相关联 使用x，y坐标系统在固体支持物上进行样品测绘，并将组织样本的坐标映射到固体支持物上，以将含有区域的组织样本与固体支持物上的空白区域区分开。 在第二方面，本发明提供了一种用于定位位于固体支撑体上的一个或多个基本圆形的组织样本的装置。

    PREDICTIVE AUTOFOCUSING
    48.
    发明申请
    PREDICTIVE AUTOFOCUSING 有权
    预测自动注册

    公开(公告)号：US20080266440A1

    公开(公告)日：2008-10-30

    申请号：US11843754

    申请日：2007-08-23

    申请人： Siavash Yazdanfar ,  Robert John Filkins ,  Elizabeth Lokenberg Dixon ,  Walter Vincent Dixon ,  Krenar Tasimi ,  Kevin Bernard Kenny

    发明人： Siavash Yazdanfar ,  Robert John Filkins ,  Elizabeth Lokenberg Dixon ,  Walter Vincent Dixon ,  Krenar Tasimi ,  Kevin Bernard Kenny

    IPC分类号： H04N5/225 ,  H04N5/232

    CPC分类号： G02B21/244 ,  G02B21/365

    摘要： A method of autofocusing includes capturing first, second and third images of a sample, at respective first, second and third sample distances and respective first, second and third lateral positions determined with respect to an objective; determining a quantitative characteristic for the first, second and third images; determining a primary sample distance based upon at least the quantitative characteristics for the first, second, and third images; and capturing a primary image of the sample at the primary sample distance and at a primary lateral position that is offset from the first, second and third lateral positions.

    摘要翻译： 自动对焦的方法包括：以相对于目标确定的各自的第一，第二和第三采样距离以及相应的第一，第二和第三横向位置捕获样本的第一，第二和第三图像; 确定第一，第二和第三图像的定量特性; 至少基于第一，第二和第三图像的定量特性来确定主样本距离; 以及在所述主要采样距离处和在偏离所述第一，第二和第三横向位置的主横向位置处捕获所述样本的主要图像。

    Tunable laser
    49.
    发明授权
    Tunable laser 有权
    可调谐激光

    公开(公告)号：US07411991B2

    公开(公告)日：2008-08-12

    申请号：US10815907

    申请日：2004-03-31

    申请人： Brian Lee Lawrence ,  Marc Dubois ,  Robert John Filkins

    发明人： Brian Lee Lawrence ,  Marc Dubois ,  Robert John Filkins

    IPC分类号： H01S3/081

    CPC分类号： H01S3/09415 ,  G11B7/0065 ,  G11B7/127 ,  H01S3/0815 ,  H01S3/1062 ,  H01S3/109 ,  H01S3/1623 ,  H01S3/1631

    摘要： Embodiments of methods, apparatuses, devices, and/or systems for a tunable laser are described. An apparatus includes: a tunable laser cavity including at least three mirrors, at least one filter and a plurality of crystals, wherein the three mirrors are substantially arranged in a lambda configuration, the filter includes a birefringent filter and an etalon, at least one of the crystals comprises a Cologuiriite crystal, and at least one other of the crystals comprises a nonlinear crystal, wherein the mirrors, the filter, and the plurality are configured for providing electromagnetic radiation of an approximately single frequency; and at least one electromagnetic radiation source being coupled to the laser cavity, wherein the electromagnetic radiation source is capable of providing electromagnetic radiation having an approximately particular wavelength to the laser cavity.

    摘要翻译： 描述了可调谐激光器的方法，装置，装置和/或系统的实施例。 一种装置包括：可调激光腔，包括至少三个反射镜，至少一个滤光器和多个晶体，其中三个反射镜基本上以λ构型布置，滤光器包括双折射滤光器和标准具，至少一个 所述晶体包括Cologuiriite晶体，并且所述晶体中的至少一个晶体包括非线性晶体，其中所述反射镜，所述滤光器和所述多个晶体被配置用于提供近似单个频率的电磁辐射; 以及耦合到所述激光腔的至少一个电磁辐射源，其中所述电磁辐射源能够向所述激光腔提供具有近似特定波长的电磁辐射。