利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

62 条记录 (耗时 0.028 秒)

    Vanadium resistant coating system
    41.
    发明授权
    Vanadium resistant coating system 有权
    耐钒涂层系统

    公开(公告)号：US08337996B2

    公开(公告)日：2012-12-25

    申请号：US12951350

    申请日：2010-11-22

    申请人： Surinder Singh Pabla ,  Vinod Kumar Pareek ,  Suchismita Sanyal ,  Krishnamurthy Anand ,  Prajina Bhattacharya

    发明人： Surinder Singh Pabla ,  Vinod Kumar Pareek ,  Suchismita Sanyal ,  Krishnamurthy Anand ,  Prajina Bhattacharya

    IPC分类号： B21D39/00

    CPC分类号： C23C24/08 ,  C23C28/321 ,  C23C28/3215 ,  C23C28/345 ,  C23C28/3455 ,  C23C28/36 ,  Y02T50/67 ,  Y10T428/12549 ,  Y10T428/12611

    摘要： A vanadium resistant coating system resistant to high temperature vanadium attack. The system comprises a high temperature superalloy substrate. A bond coat overlies the superalloy substrate. The bond coat may be applied in multiple layers. A ceramic coating overlies the bond coat. The ceramic coating further comprises a zirconium oxide stabilized by at least one cation selected from the group consisting of Yb3+, Lu3+, Sc3+ and Ce4+, in the amounts of about 5-10 weight percent. An overcoat may overlie the ceramic coating. The overcoat may be a sacrificial layer of YSZ infiltrated with cations having an atomic radius larger than Y3+. Alternatively, the overcoat may comprise zirconium oxide stabilized by Ce4+.

    摘要翻译： 耐高温钒攻击的耐钒涂层体系。 该系统包括高温超合金基底。 粘合涂层覆盖在超合金基板上。 粘合涂层可以多层施用。 陶瓷涂层覆盖在粘结层上。 所述陶瓷涂层还包含以约5-10重量％的量由至少一种选自Yb3 +，Lu3 +，Sc3 +和Ce4 +的阳离子稳定的氧化锆。 外涂层可能覆盖陶瓷涂层。 外涂层可以是原子半径大于Y 3 +的阳离子渗透的YSZ的牺牲层。 或者，外涂层可以包括由Ce 4+稳定的氧化锆。

    Variable current charge pump with modular switch circuit
    43.
    发明授权
    Variable current charge pump with modular switch circuit 有权
    可变电流电荷泵，带模块开关电路

    公开(公告)号：US07570105B1

    公开(公告)日：2009-08-04

    申请号：US11867416

    申请日：2007-10-04

    申请人： Sun Woo Baek ,  Henry Y. Lui ,  Surinder Singh

    发明人： Sun Woo Baek ,  Henry Y. Lui ,  Surinder Singh

    IPC分类号： G05F1/10

    CPC分类号： H03L7/0898 ,  H03L7/0814 ,  H03L7/0896

    摘要： A charge pump circuit includes switch circuit modules and current modules. The number of switch circuit modules that are coupled to receive current from one of the current modules is variable. The output current of the charge pump circuit increases as more of the switch circuit modules are coupled to receive current from the current modules. The net on-resistance of the switch circuit modules decreases as more of the switch circuit modules are coupled to receive current from the current modules. Charge coupling caused by the net parasitic gate-to-drain capacitance of switching transistors in the switch circuit modules is reduced at smaller output current settings of the charge pump circuit.

    摘要翻译： 电荷泵电路包括开关电路模块和电流模块。 耦合以从当前模块之一接收电流的开关电路模块的数量是可变的。 随着更多的开关电路模块被耦合以从当前模块接收电流，电荷泵电路的输出电流增加。 开关电路模块的净导通电阻随着更多的开关电路模块被耦合以从当前模块接收电流而减小。 开关电路模块中的开关晶体管的净寄生栅极到漏极电容引起的电荷耦合在电荷泵电路的较小输出电流设置下被减小。

    Bovine germline D-genes and their application
    45.
    发明授权
    Bovine germline D-genes and their application 有权
    牛种系D基因及其应用

    公开(公告)号：US07196185B2

    公开(公告)日：2007-03-27

    申请号：US10429979

    申请日：2003-05-06

    申请人： Azad Kumar Kaushik ,  Surinder Singh Saini ,  Farbod Shojaei

    发明人： Azad Kumar Kaushik ,  Surinder Singh Saini ,  Farbod Shojaei

    IPC分类号： C07H21/04 ,  C12N15/74

    CPC分类号： C07K16/00 ,  C07K2317/565

    摘要： The present invention relates to a bovine VDJ cassette (BF1H1) that provides the novel ability to develop chimeric immunoglobulin molecule capable of incorporating both linear T cell epitope(s) (CDR1H and CDR2H) as well as conformational B cell epitope(s) (exceptionally long CDR3H). Further, multiple epitopes can be incorporated for development of multivalent vaccine by replacing at least a portion of an immunoglobulin molecule with the desired epitope such that functional ability of both epitope(s) and parent VDJ rearrangement is retained. The antigenized immunoglobulin incorporating both T and B epitopes of interest is especially useful for development of oral vaccines for use in humans apart from other species including cattle. The long CDR3H in BF1H1 VDJ rearrangement originates from long germline D-genes. The novel bovine germline D-genes provide unique molecular genetic marker for sustaining the D-gene pool in cattle essential for immunocompetence via selective breeding. D-gene specific DNA probe permits typing and selection of breeding cattle stock for maximum gemline D gene pool for better health and disease prevention. The bovine D-genes are unique to cattle and, therefore, provide sensitive and specific forensic analytical tool using molecular biology techniques to determine tissues suspected of bovine origin.

    摘要翻译： 牛VDJ盒（BF1H1）本发明涉及能够开发能够并入线性T细胞表位（CDR1H和CDR2H）以及构象B细胞表位（特异性）的嵌合免疫球蛋白分子的新型能力的牛VDJ盒（BF1H1） 长CDR3H）。 此外，通过用所需表位置换至少一部分免疫球蛋白分子，可以并入多个表位以开发多价疫苗，使得保留表位和亲本VDJ重排的功能能力。 结合感兴趣的T和B表位的抗原免疫球蛋白特别可用于开发除包括牛在内的其他物种以外的人的口服疫苗。 BF1H1 VDJ重排中的长CDR3H来自长种D基因。 新型牛种系D基因提供独特的分子遗传标记，用于通过选择性育种来维持免疫能力所必需的牛中的D基因库。 D基因特异性DNA探针允许打印和选择繁殖牛的最大宝石D基因库，以获得更好的健康和疾病预防。 牛D基因是牛特有的，因此，使用分子生物学技术提供敏感和特异性的法医分析工具来确定怀疑有牛来源的组织。

    Bovine VDJ cassette, BF1H1, suitable for antigenization
    48.
    发明授权
    Bovine VDJ cassette, BF1H1, suitable for antigenization 失效
    牛VDJ盒，BF1H1，适用于抗原

    公开(公告)号：US06740747B2

    公开(公告)日：2004-05-25

    申请号：US10125594

    申请日：2002-04-19

    申请人： Azad Kaushik ,  Surinder Singh Saini

    发明人： Azad Kaushik ,  Surinder Singh Saini

    IPC分类号： C07H2102

    CPC分类号： C07K16/00 ,  C07K2317/565

    摘要： The present invention relates to a bovine VDJ cassette (BF1H1) that provides the novel ability to develop chimeric immunoglobulin molecule capable of incorporating both linear T cell epitope(s) (CDR1H and CDR2H) as well as conformational B cell epitope(s) (exceptionally long CDR3H). The antigenized immunoglobulin incorporating both T and B epitopes of interest is especially useful for development of oral vaccines for use in humans apart from other species including cattle. The long CDR3H in BF1H1 VDJ rearrangement originates from long germline D-genes. The novel bovine germline D-genes provide additional opportunities for sustaining the capacity for antibody diversification in cattle essential for immunocompetence via selective breeding strategies that incorporate immunoglobulin gene markers. The novel gene elements, such as D-genes, are unique to cattle and, therefore, are useful in forensic analysis.

    摘要翻译： 牛VDJ盒（BF1H1）本发明涉及能够开发能够并入线性T细胞表位（CDR1H和CDR2H）以及构象B细胞表位（特异性）的嵌合免疫球蛋白分子的新型能力的牛VDJ盒（BF1H1） 长CDR3H）。 结合感兴趣的T和B表位的抗原免疫球蛋白特别可用于开发除包括牛在内的其他物种以外的人的口服疫苗。 BF1H1 VDJ重排中的长CDR3H来自长种D基因。 新型牛种系D基因提供了额外的机会，通过结合免疫球蛋白基因标记的选择性育种策略为维持免疫能力所必需的牛抗体多样化能力。 新基因元件，如D基因，是牛特有的，因此在法医分析中是有用的。

    3-hydroxy-pyridin-4-ones useful for treating parasitic infections
    49.
    发明授权
    3-hydroxy-pyridin-4-ones useful for treating parasitic infections 失效
    可用于治疗寄生虫感染的3-羟基 - 吡啶-4-酮

    公开(公告)号：US5256676A

    公开(公告)日：1993-10-26

    申请号：US918080

    申请日：1992-07-24

    申请人： Robert C. Hider ,  Timothy E. A. Peto ,  Surinder Singh ,  Susan Whitehead

    发明人： Robert C. Hider ,  Timothy E. A. Peto ,  Surinder Singh ,  Susan Whitehead

    IPC分类号： A61K31/14 ,  A61K31/44 ,  C07D213/69 ,  C07D211/74

    CPC分类号： C07D213/69 ,  A61K31/14 ,  A61K31/44

    摘要： 3-Hydroxypyridin-4-ones of formula (I) ##STR1## in which R.sub.1 is a C.sub.3 or C.sub.4 hydroxyalkyl group in which the hydroxy group is terminally substituted on the alkyl group, R.sub.2 is methyl or ethyl and R.sub.3 and R.sub.4 are each separately hydrogen, methyl or ethyl but with the proviso that the total number of carbon atoms in R.sub.1 to R.sub.4 is no more than six, the compound optionally being in the form of a physiologically acceptable salt and/or pro-drug thereof, are of value for the treatment of conditions caused by iron dependent parasites, particularly malaria.

    摘要翻译： 式（I）的3-羟基吡啶-4-酮其中R1是其中羟基被烷基末端取代的C3或C4羟烷基，R2是甲基或乙基，R3和R4 分别为氢，甲基或乙基，但条件是R1至R4中的碳原子总数不超过6，任选呈生理上可接受的盐和/或其前体形式的化合物为 治疗由铁依赖寄生虫，特别是疟疾引起的病症的价值。