公开(公告)号：US20060127375A1

公开(公告)日：2006-06-15

申请号：US11334950

申请日：2006-01-18

申请人： Stephen Livesey ,  Michael Burnett ,  Jerome Connor ,  Christopher Wagner

发明人： Stephen Livesey ,  Michael Burnett ,  Jerome Connor ,  Christopher Wagner

IPC分类号： A61K35/14 ,  A01N1/02 ,  A61K31/70 ,  A61K31/7048 ,  A61K31/522 ,  A61K31/7012

CPC分类号： A01N1/02 ,  A01N1/0226 ,  A61K35/18

摘要： A red blood cell storage composition includes a composition of red blood cells and biochemistry altering reagents, the biochemistry altering reagents being present at a concentration so as to reduce the percent hemolysis of the red blood cells during the freeze-thaw cycle below that of the percent hemolysis of the red blood cells in the absence the biochemistry altering reagents. The red blood cell storage composition preferably includes reagents selected from: modifiers of glycolytic/metabolic components, modifiers of antioxidant potential, effectors of intracellular ionic distribution, modifiers of membrane fluidity, modifiers of cytoskeletal structure, effectors of the cyclooxygenase second messenger pathway, effectors of the lipoxygenase second messenger pathway, effectors of the hexose monophosphate second messenger pathway, effectors of the phosphorylation second messenger pathway, modifiers of specific messenger molecules, and combinations thereof.

摘要翻译： 红细胞储存组合物包括红细胞和生物化学改变试剂的组合物，所述生物化学改变试剂以浓度存在，以便将冻融循环期间的红细胞溶血百分比降低至百分比以下 在没有生物化学改变试剂的情况下红细胞溶血。 红细胞储存组合物优选包括选自以下的试剂：糖酵解/代谢组分的改性剂，抗氧化剂潜力的改性剂，细胞内离子分布的作用剂，膜流动性的调节剂，细胞骨架结构的改性剂，环加氧酶第二信使途径的作用者， 脂氧合酶第二信使通路，己糖单磷酸第二信使途径的作用子，磷酸化第二信使途径的作用剂，特异信使分子的改性剂及其组合。