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    Hydrogel intervertebral disc nucleus
    47.
    发明授权
    Hydrogel intervertebral disc nucleus 失效
    水凝胶椎间盘核

    公开(公告)号：US5976186A

    公开(公告)日：1999-11-02

    申请号：US670140

    申请日：1996-06-25

    申请人： Qi-Bin Bao ,  Paul A. Higham

    发明人： Qi-Bin Bao ,  Paul A. Higham

    IPC分类号： A61F2/00 ,  A61F2/44

    CPC分类号： A61F2/442 ,  A61F2/441 ,  A61F2002/30298 ,  A61F2002/4435 ,  A61F2002/444 ,  A61F2230/0091 ,  Y10S623/908

    摘要： An article for use in the preparation of a hydrogel prosthetic nucleus, for an intervertebral disc, having equilibrium water contents (EWCs) of from about 30 to about 90% and compressive strengths of at least 4 meganewtons per square meter (MNm.sup.-2), at their EWCs, when subjected to the same constraints as the normal nucleus, comprising one or more xerogel rods containing from zero to less than the EWC. A method for preparing a hydrogel prosthetic nucleus, for a vertebral disc, comprising one or more hydrogel rods containing from about 30 to about 90% water, and having compressive strengths of at least 1 MNm.sup.-2, at their EWCs, which comprises inserting one or more hydrophilic xerogel rods, which at their EWC will contain from about 30 to about 90% water and have compressive strengths of at least 1 MNm.sup.-2, containing water in an amount from about zero to less than their EWC, into the cavity of the disc through an opening in its annulus and allowing the rod, or rods, to absorb sufficient water from the body fluids to attain their EWCs and essentially fill the intervertebral nuclear disc cavity.

    摘要翻译： 用于制备水凝胶假体核的用于椎间盘的物品，其具有约30至约90％的平衡含水量（EWC）和至少4麦克/平方米（MNm-2）的压缩强度， 在其EWC下，当受到与正常核相同的限制时，其包含一个或多个含有零至小于EWC的干凝胶棒。 一种制备用于椎间盘的水凝胶假体核的方法，包括一个或多个含有约30至约90％的水并且在其EWC处具有至少1MNm-2的压缩强度的水凝胶棒，其包括插入一个 或更多的亲水性干凝胶棒，其在它们的EWC下将含有约30至约90％的水，并且具有至少1MNm-2的压缩强度，其含量为约零至小于其EWC的量， 盘通过其环中的开口并允许杆或杆从体液吸收足够的水以实现其EWC并且基本上填充椎间核盘腔。

    Dehydration of hydrogels
    49.
    发明授权
    Dehydration of hydrogels 失效
    水凝胶脱水

    公开(公告)号：US5705780A

    公开(公告)日：1998-01-06

    申请号：US459574

    申请日：1995-06-02

    申请人： Qi-Bin Bao

    发明人： Qi-Bin Bao

    IPC分类号： C08F6/24 ,  C08J7/02 ,  C07C1/00 ,  C07C2/00 ,  C07C4/00 ,  C07C5/00

    CPC分类号： C08J9/28 ,  C08F6/24 ,  C08J7/02 ,  C08J2329/04 ,  Y10S524/916

    摘要： A method of dehydration of bulky hydrogel samples of polyvinyl alcohol (i.e., PVA) and a method of preparation of prosthetic nuclei for vertebral discs are given. A method of gamma irradiation sterilization of PVA gel samples which does not incur the side effects of discoloration and of increased crystallinity (i.e., further reduction of water content) is also given. A method of dehydrating bulky hydrogel samples of polyvinyl alcohol (i.e., PVA) so that no significant distortion in the samples results, comprises: (a) subjecting the sample to a solvent system comprising at least one organic solvent which (1) has a solubility for PVA which is less than the solubility of water for PVA and (2) is miscible with water for a length of time generally from about 2 to about 10 days so that the dehydration rate of the hydrogel samples is sufficiently slow so as not to cause any distortions on the dehydrated samples.

    摘要翻译： 给出了聚乙烯醇（即PVA）的大体积水凝胶样品的脱水方法和用于椎间盘的假体核的制备方法。 还给出了不引起变色和增加的结晶度的副作用（即进一步降低水分含量）的PVA凝胶样品的γ辐射灭菌方法。 使聚乙烯醇（即PVA）的大体积水凝胶样品脱水以使样品中没有明显变形的方法包括：（a）使样品经受包含至少一种有机溶剂的溶剂体系，所述溶剂体系（1）具有溶解度 对于低于PVA对PVA的溶解度的PVA，和（2）通常在约2至约10天的时间内可与水混溶，使得水凝胶样品的脱水速度足够慢以致不会引起 对脱水样品的任何扭曲。