公开(公告)号：US20150315148A1

公开(公告)日：2015-11-05

申请号：US14707874

申请日：2015-05-08

Applicant: Constellation Pharmaceuticals, Inc.

Inventor： Brian K. Albrecht ,  James Edmund Audia ,  Alexandre Gagnon ,  Jean-Christophe Harmange ,  Christopher G. Nasveschuk

IPC: C07D213/64 ,  C07D213/81 ,  C07D401/12 ,  C07D405/12

CPC classification number: C07D213/64 ,  C07D213/81 ,  C07D401/12 ,  C07D405/12

Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

公开(公告)号：US20150065522A1

公开(公告)日：2015-03-05

申请号：US14477566

申请日：2014-09-04

Applicant: Genentech, Inc. ,  Constellation Pharmaceuticals, Inc.

Inventor： Brian K. Albrecht ,  Steven F. Bellon ,  Victor S. Gehling ,  Jean-Christophe Harmange ,  Yves LeBlanc ,  Jun Liang ,  Steven Magnuson ,  Vicki Tsui ,  Birong Zhang

IPC: C07D487/04 ,  A61K45/06 ,  A61N5/10 ,  A61K31/519

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61N5/10

Abstract: The present invention relates to compounds formula (I): and to salts thereof, wherein R1-R4 and A have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of histone demethylases, such as KDM5. Also included are pharmaceutically acceptable compositions comprising the compounds of the present invention and methods of using said compositions in the treatment of various disorders.

Abstract translation: 本发明涉及式（I）化合物及其盐，其中R 1 -R 4和A具有说明书中定义的任何值及其组成和用途。 该化合物可用作组蛋白脱甲基酶的抑制剂，例如KDM5。 还包括包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。