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    ENANTIOPURE QUINUCLIDINYLOXY PYRIDAZINES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
    42.
    发明申请
    ENANTIOPURE QUINUCLIDINYLOXY PYRIDAZINES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 审中-公开
    纯化喹啉吡啶吡啶并使用它作为NICOTINIC乙酰胆碱受体配体

    公开(公告)号：US20100227869A1

    公开(公告)日：2010-09-09

    申请号：US12160402

    申请日：2007-02-13

    申请人： Dan Peters ,  Daniel B. Timmermann ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Tino Dyhring

    发明人： Dan Peters ,  Daniel B. Timmermann ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Tino Dyhring

    IPC分类号： A61K31/501 ,  C07D403/12 ,  A61P25/00 ,  A61P29/00 ,  A61P1/00 ,  A61P9/12 ,  A61P15/00 ,  A61P17/00

    CPC分类号： C07D453/02

    摘要： This invention relates to novel enantiopure azabicyclo pyridazinyloxy derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新型对映纯氮氮杂双环哒嗪氧基衍生物，其被发现是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Diazabicyclic aryl derivatives and their medical use
    44.
    发明授权
    Diazabicyclic aryl derivatives and their medical use 失效
    二氮杂双环芳基衍生物及其医疗用途

    公开(公告)号：US07750011B2

    公开(公告)日：2010-07-06

    申请号：US11884345

    申请日：2006-02-13

    申请人： Dan Peters ,  Daniel B. Timmermann ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Tino Dyhring

    发明人： Dan Peters ,  Daniel B. Timmermann ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Tino Dyhring

    IPC分类号： C07D403/04 ,  C07D401/04 ,  C07D409/04 ,  C07D405/14 ,  A61K31/501 ,  A61K31/497 ,  A61P21/00 ,  A61P5/00 ,  A61P25/00 ,  A61P29/00

    CPC分类号： C07D487/08

    摘要： This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及在尼古丁乙酰胆碱受体和单胺受体和转运蛋白的调节剂中被发现是胆碱能配体的新的二氮杂双环芳基衍生物。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Diazabicyclic aryl derivatives as cholinergy ligands
    46.
    发明授权
    Diazabicyclic aryl derivatives as cholinergy ligands 失效
    二氮杂双环芳基衍生物作为胆碱能配体

    公开(公告)号：US07612074B2

    公开(公告)日：2009-11-03

    申请号：US11663967

    申请日：2005-11-29

    申请人： Dan Peters ,  Daniel B. Timmermann ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Tino Dyhring Jørgensen

    发明人： Dan Peters ,  Daniel B. Timmermann ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Tino Dyhring Jørgensen

    IPC分类号： A61K31/497

    CPC分类号： C07D487/08

    摘要： This invention relates to novel diazabicyclic aryl compounds of the formula wherein: R′ represents hydrogen or alkyl; A represents an aromatic monocyclic or bicyclic carbocyclic or heterocyclic; and is hydrogen or a subsituent as defined in the specification. The compounds are cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. The compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及下式的新的二氮杂双环芳基化合物：其中：R'表示氢或烷基; A表示芳族单环或双环碳环或杂环; 并且是如本说明书中定义的氢或取代基。 这些化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS）的胆碱能系统，与平滑肌收缩有关的疾病或病症的疾病或病症多种化的疾病或病症， 内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状有关的疾病或病症。

    Diazabicyclic aryl derivatives as cholinergic receptor modulators
    50.
    发明授权
    Diazabicyclic aryl derivatives as cholinergic receptor modulators 失效
    二氮杂双环芳基衍生物作为胆碱能受体调节剂

    公开(公告)号：US07662808B2

    公开(公告)日：2010-02-16

    申请号：US10586836

    申请日：2005-02-01

    申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Tino Dyhring Jørgensen ,  Daniel B Timmermann

    发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Østergaard Nielsen ,  Tino Dyhring Jørgensen ,  Daniel B Timmermann

    IPC分类号： A01N43/00 ,  A61K31/33 ,  C07D487/00

    CPC分类号： C07D471/08

    摘要： This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemicals substances.

    摘要翻译： 本发明涉及新的二氮杂双环芳基衍生物，其在烟碱乙酰胆碱受体和单胺受体和转运蛋白的调节剂中被发现是胆碱能配体。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。