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公开(公告)号:US6127354A
公开(公告)日:2000-10-03
申请号:US270862
申请日:1999-03-17
IPC分类号: A61K31/165 , A61K31/17 , A61K31/18 , A61K31/27 , A61K31/381 , A61K31/40 , A61K31/472 , A61K31/495 , A61P5/06 , C07C237/22 , C07C243/34 , C07C281/06 , C07C311/08 , C07C311/21 , C07D207/08 , C07D211/06 , C07D217/06 , C07D241/08 , C07D333/20 , A61K31/135 , A61K31/166 , C07D333/16
CPC分类号: C07D207/08 , C07C237/22 , C07C281/06 , C07C311/08 , C07C311/21 , C07D217/06 , C07D241/08 , C07D333/20
摘要: Novel peptide derivatives, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone are disclosed. The peptides have the formula (I): ##STR1## wherein a, b, A, R.sup.1, L.sup.1, D, R.sup.3, R.sup.4, R.sup.2, L.sup.2, E and G are as defined in the specification. These peptides exhibit improved resistance to proteolytic degradation, and hence, improved bioavailability.
摘要翻译: 公开了新型肽衍生物,含有它们的组合物及其用于治疗由生长激素缺乏引起的医学疾病的用途。 肽具有式(I):其中a,b,A,R1,L1,D,R3,R4,R2,L2,E和G如说明书中所定义。 这些肽表现出改善的蛋白水解降解抗性,因此提高了生物利用度。
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公开(公告)号:US6020349A
公开(公告)日:2000-02-01
申请号:US962098
申请日:1997-10-31
申请人: Michael Ankersen , Florenzio Zaragoza Dorwald , Carsten Enggaard Stidsen , Albert Michael Crider
发明人: Michael Ankersen , Florenzio Zaragoza Dorwald , Carsten Enggaard Stidsen , Albert Michael Crider
IPC分类号: A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/4545 , A61P1/00 , A61P3/04 , A61P3/10 , A61P9/00 , A61P11/00 , A61P25/00 , A61P27/02 , A61P43/00 , C07D213/74 , C07D295/194 , C07D401/12 , C07D401/14 , C07D401/02
CPC分类号: C07D213/74 , C07D401/12 , C07D401/14 , Y10S514/866
摘要: The present invention relates to a compound of general formula I ##STR1## for treating medical disorders related to binding to human somatostatin receptor subtypes.
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公开(公告)号:US5922770A
公开(公告)日:1999-07-13
申请号:US896550
申请日:1997-07-17
IPC分类号: A61K31/165 , A61K31/17 , A61K31/18 , A61K31/27 , A61K31/381 , A61K31/40 , A61K31/472 , A61K31/495 , A61P5/06 , C07C237/22 , C07C243/34 , C07C281/06 , C07C311/08 , C07C311/21 , C07D207/08 , C07D211/06 , C07D217/06 , C07D241/08 , C07D333/20 , C07C233/11 , C07C235/34
CPC分类号: C07D207/08 , C07C237/22 , C07C281/06 , C07C311/08 , C07C311/21 , C07D217/06 , C07D241/08 , C07D333/20
摘要: Novel peptide derivatives, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone are disclosed. The peptides have the formula (I): ##STR1## wherein a, b, A, R.sup.1, L.sup.1, D, R.sup.3, R.sup.4, R.sup.2, L.sup.2, E and G are as defined in the specification. These peptides exhibit improved resistance to proteolytic degradation, and hence, improved bioavailability.
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