公开(公告)号：US20180162835A1

公开(公告)日：2018-06-14

申请号：US15837393

申请日：2017-12-11

Applicant: FORMA Therapeutics, Inc.

Inventor： Stephanos Ioannidis ,  Adam Charles Talbot ,  Bruce Follows ,  Alexandre Joseph Buckmelter ,  Minghua Wang ,  Ann-Marie Campbell ,  David R. Lancia, JR.

IPC: C07D401/06 ,  C07D487/04 ,  C07D471/04 ,  C07D239/88

CPC classification number: C07D401/06 ,  C07D239/88 ,  C07D471/04 ,  C07D487/04

Abstract: The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R4′, X1, Y1, Y2, Y3, Y4, n, and m are described herein.

公开(公告)号：US09938300B2

公开(公告)日：2018-04-10

申请号：US15015566

申请日：2016-02-04

Applicant: Forma Therapeutics, Inc.

Inventor： Stephanos Ioannidis ,  Adam Charles Talbot ,  Bruce Follows ,  Alexandre Joseph Buckmelter ,  Minghua Wang ,  Ann-Marie Campbell

IPC: A01N43/90 ,  A61K31/519 ,  C07D471/00 ,  C07D487/00 ,  C07D513/04 ,  C07D487/04

CPC classification number: C07D513/04 ,  C07D487/04

Abstract: The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R5, R5′, X1, X2, X3, n, and m are described herein.