公开(公告)号：US20080182775A1

公开(公告)日：2008-07-31

申请号：US11518209

申请日：2006-09-11

申请人： Gen Sobue ,  Masahisa Katsuno ,  Hiroaki Adachi

发明人： Gen Sobue ,  Masahisa Katsuno ,  Hiroaki Adachi

IPC分类号： A61K38/22 ,  A61P21/00

CPC分类号： C12N15/8509 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/0306

摘要： It is intended to provide a model animal faithfully reproducing the pathogenic conditions of spinal and bulbar muscular atrophy, a method of screening a remedy for polyglutamine disease using the same, and a remedy for spinal and bulbar muscular atrophy. Namely, a nonhuman animal having the following characteristics (1) to (5) in its conditions or pathological findings: (1) showing progressive myoatrophy; (2) showing lowering in muscular power; (3) in immunostaining with the use of an anti-polyglutamine antibody, showing nuclear diffuse staining and nuclear inclusions; (4) in immunostaining with the use of an anti-androgen receptor antibody, showing nuclear diffuse staining and nuclear inclusions; and (5) showing a neurogenic change. A remedy for polyglutamine disease is screened by administering a test substance to this nonhuman animal and examining changes in its conditions or pathological findings. A remedy for spinal and bulbar muscular atrophy is prepared by using as the active ingredient a compound having an effect of inhibiting the secretion of testosterone.

摘要翻译： 旨在提供一种忠实地复制脊髓和延髓肌肉萎缩的致病条件的模型动物，使用其来筛选聚谷氨酰胺疾病的治疗方法，以及脊髓和延髓肌肉萎缩的补救措施。 即，具有以下特征（1）〜（5）的病例或病理结果的非人动物：（1）显示进行性肌萎缩; （2）显示肌肉力量的下降; （3）在使用抗多聚谷氨酰胺抗体的免疫染色中显示核扩散染色和核内含物; （4）使用抗雄激素受体抗体进行免疫染色，显示核扩散染色和核内含物; 和（5）显示神经源性变化。 通过向该非人动物施用测试物质并检查其病症或病理学发现的变化来筛选聚谷氨酰胺病的补救措施。 通过使用具有抑制睾酮分泌作用的化合物作为活性成分制备脊髓和延髓肌肉萎缩的补救措施。

公开(公告)号：US20080119281A1

公开(公告)日：2008-05-22

申请号：US11822791

申请日：2007-07-10

申请人： Kazuki Hirose ,  Shinichiro Tamaki ,  Tetsuya Sasaki ,  Tsutomu Araki ,  Hiroaki Adachi

发明人： Kazuki Hirose ,  Shinichiro Tamaki ,  Tetsuya Sasaki ,  Tsutomu Araki ,  Hiroaki Adachi

IPC分类号： G06F17/00

CPC分类号： A63F13/87 ,  A63F13/12 ,  A63F13/35 ,  A63F13/352 ,  A63F13/795 ,  A63F2300/513 ,  A63F2300/537 ,  A63F2300/556 ,  A63F2300/638 ,  G06Q10/107 ,  G06Q30/0209 ,  H04L51/00 ,  H04L51/12

摘要： A game apparatus includes an input-output processor, and by following an instruction from the input-output processor, messages are transmitted and received with other game apparatus 12 connected via a network. The messages are transmitted and received in an electronic mail format, and has identification information of an application being a creation source of the message as well as general information, such as a transmission source, a destination and a subject as header information.

摘要翻译： 游戏装置包括输入输出处理器，并且通过跟随来自输入输出处理器的指令，经由网络连接的其他游戏装置12发送和接收消息。 消息以电子邮件格式发送和接收，并且具有作为消息的创建源的应用的标识信息以及作为头信息的一般信息，例如发送源，目的地和主题。