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公开(公告)号：US20220288311A1
公开(公告)日：2022-09-15
申请号：US17687808
申请日：2022-03-07
Applicant: Insulet Corporation
Inventor： Joon Bok LEE , Yibin ZHENG , Jason O'CONNOR
Abstract: Exemplary embodiments may modify the cost function parameters based on current and projected mean outcomes in blood glucose level control performance. The exemplary embodiments may modify the weight coefficient R for the insulin cost so that the value of R is not fixed and is not based solely on clinical determined values. Exemplary embodiments may also adjust the cost function to address persistent low-level blood glucose level excursions for users. The exemplary embodiments may reduce the penalty of the insulin cost by the sum of the converted insulin cost of the glucose excursions above target for a period divided by a number of cycles of average insulin action time. The AID system reduces the insulin cost by the lack of insulin in previous cycles.
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公开(公告)号：US20220249773A1
公开(公告)日：2022-08-11
申请号：US17665165
申请日：2022-02-04
Applicant: Insulet Corporation
Inventor： Yibin ZHENG , Joon Bok LEE , Jason O'CONNOR
Abstract: Disclosed are techniques, a system and devices that enable the setting of an upper boundary constraint that may be a multiple of a total daily dosage setting for a liquid drug being administered to a user to control a condition, such as type 1 or type 2 diabetes mellitus. An automatic drug delivery algorithm may be configured to obtain a glucose control metric. A controller executing the automatic drug delivery algorithm may ascertain, based on the glucose control metric, an upper boundary constraint for the liquid drug that limits an amount of a dose of the liquid drug that may be delivered by the automatic drug delivery system or components thereof.
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43.发明申请公开(公告)号：US20220226576A1
公开(公告)日：2022-07-21
申请号：US17715589
申请日：2022-04-07
Applicant: INSULET CORPORATION
Inventor： Yibin ZHENG , Joon Bok LEE , Ashutosh ZADE , Jason O'CONNOR
Abstract: Exemplary embodiments may address the problem of missing blood glucose concentration readings from a glucose monitor that transmits blood glucose concentration readings over a wireless connection due to problems with the wireless connection. In the exemplary embodiments, an automated insulin delivery (AID) device uses an estimate in place of a missing blood glucose concentration reading in determining a predicted future blood glucose concentration reading for a user. Thus, the AID device is able to operate normally in generating insulin delivery settings despite not receiving a current blood glucose concentration reading for a current cycle. There is no need to suspend delivery of insulin to the user due to the missing blood glucose concentration reading.
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公开(公告)号：US20220062545A1
公开(公告)日：2022-03-03
申请号：US17008054
申请日：2020-08-31
Applicant: Insulet Corporation
Inventor： Ashutosh ZADE , Joon Bok LEE , Yibin ZHENG
Abstract: Techniques and devices for determining and generating insulin formulations are described. An automated insulin delivery device may include a wireless interface with a glucose sensor for providing blood glucose concentration readings of a user, a plurality of insulin reservoirs, each of the plurality of insulin reservoirs holding a different one of a plurality of insulin types, each of the plurality of insulin types having a different strength, a storage medium storing programming instructions and user glucose information, the user glucose information comprising the blood glucose concentration readings, predicted future blood glucose concentration readings, and user activity information, determining an insulin strength based on the user glucose information, determining an insulin formulation ratio to generate an insulin formulation having the insulin strength using the plurality of insulin types, an insulin formulation device to generate the insulin formulation; and an insulin delivery component to deliver the insulin formulation to the user.
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公开(公告)号：US20220061706A1
公开(公告)日：2022-03-03
申请号：US17003854
申请日：2020-08-26
Applicant: Insulet Corporation
Inventor： Ashutosh ZADE , Joon Bok LEE , Yibin ZHENG , Steven CARDINALI
Abstract: Methods and apparatuses for performing a blood glucose monitoring process are described. For example, an apparatus may include at least one memory and logic coupled to the at least one memory. The logic may operate to determine patient monitoring information associated with a diabetic treatment of a patient, generate at least one monitoring information structure based on the patient monitoring information, generate at least one monitoring information image based on at least a portion of the at least one monitoring information structure, and process the at least one monitoring information image using a computational model to determine a blood glucose condition of the patient. Other embodiments are described.
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Patent Agency Ranking
46.发明申请公开(公告)号：US20210252219A1
公开(公告)日：2021-08-19
申请号：US16791648
申请日：2020-02-14
Applicant: Insulet Corporation
Inventor： Yibin ZHENG , Joon Bok LEE , Ashutosh ZADE , Jason O'Connor
Abstract: Exemplary embodiments may address the problem of missing blood glucose concentration readings from a glucose monitor that transmits blood glucose concentration readings over a wireless connection due to problems with the wireless connection. In the exemplary embodiments, an automated insulin delivery (AID) device uses an estimate in place of a missing blood glucose concentration reading in determining a predicted future blood glucose concentration reading for a user. Thus, the AID device is able to operate normally in generating insulin delivery settings despite not receiving a current blood glucose concentration reading for a current cycle. There is no need to suspend delivery of insulin to the user due to the missing blood glucose concentration reading.
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公开(公告)号：US20210228804A1
公开(公告)日：2021-07-29
申请号：US17150461
申请日：2021-01-15
Applicant: Insulet Corporation
Inventor： Eric BENJAMIN , Joon Bok LEE , Yibin ZHENG , Jason O'CONNOR , Ashutosh ZADE
Abstract: Disclosed are a device, system, methods and computer-readable medium products that provide techniques to implement functionality to receive information related to a meal and delivery of a meal bolus. The received information may be stored and utilized in the generation of insulin delivery profiles. An estimate a mealtime insulin need based on the generated insulin delivery profiles may be generated. A dose of insulin may be determined that satisfies an estimated mealtime insulin need based on the generated insulin delivery profiles. The determined dose of insulin may be output at a time corresponding to a mealtime.
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公开(公告)号：US20210187196A1
公开(公告)日：2021-06-24
申请号：US17123369
申请日：2020-12-16
Applicant: INSULET CORPORATION
Inventor： Joon Bok LEE , Jason O'CONNOR , Yibin ZHENG
Abstract: Disclosed are a device, system, methods and computer-readable medium products that provide techniques to implement functionality to receive blood glucose measurements over a period of time. An average of missing blood glucose measurement values may be maintained over a predetermined time period. A count of a number of missing blood glucose measurement values over a period of time may be established. A controller may calculate a divergence of the number of missing blood glucose measurement values over the period of time from the average of missing blood glucose measurements over the predetermined time period. Based on a value of the divergence, a determination that a safety constraint for delivery of insulin is to be reduced. The safety constraint may be reduced by a predetermined percentage. An instruction to deliver an insulin dosage may be generated according to the reduced safety constraint may be forwarded to a wearable drug delivery device.
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公开(公告)号：US20210077719A1
公开(公告)日：2021-03-18
申请号：US16570125
申请日：2019-09-13
Applicant: Insulet Corporation
Inventor： Steven CARDINALI , Joon Bok LEE , Jason O'CONNOR , Yibin ZHENG
Abstract: Disclosed are a system, methods and computer-readable medium products that provide bolus dosage calculations by a control algorithm-based drug delivery system that provides automatic delivery of a drug, such as insulin or the like, based on sensor input. Blood glucose measurement values may be received at regular time intervals from a sensor. Using the blood glucose measurements, the control algorithm may perform various calculations and determinations to provide an appropriate bolus dosage. The appropriate bolus dosage may be used to respond to a trend in a trajectory of blood glucose measurements. In addition, a bolus dosage may also be determined by the disclosed device, system, method and/or computer-readable medium product in response to an indication that a user consumed a meal.
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公开(公告)号：US20240424210A1
公开(公告)日：2024-12-26
申请号：US18749512
申请日：2024-06-20
Applicant: INSULET CORPORATION
Inventor： Mert SEVIL , Yibin ZHENG , William WHITELEY , Rangarajan NARAYANASWAMI , Saeed SALAVATI , Sam CARL
Abstract: Disclosed are a drug delivery system, a drug delivery device, a controller and a number of techniques to personalize the delivery of a bolus dosage. In an example, a drug delivery system may include a processor and a memory. The memory may be operable to store instructions that, when executed by the processor, cause the processor to receive a request to deliver a bolus dosage, retrieve a history of glucose measurement values, extract features from the history of glucose measurement values, assign a value to extracted features and calculate a personalized factor, and based on the personalized factor or factors, modify a calculation for an amount of a medicament to deliver. Additionally or alternatively, the personalized factor may be used to modify parameter settings of a medicament delivery algorithm. The described systems may track a user's personalized factor over a period of time.
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