摘要:
The present invention relates to compounds that are useful for treating cellular proliferative diseases, for treating disorders mediated, at least in part, by KSP, and for inhibiting KSP. The invention also related to pharmaceutical compositions comprising such compounds, methods of treating cancer by the administration of such compositions, and processes for the preparation of the compounds. Compounds of the invention have the following formula:
摘要:
Heteroaryl-fused pyrimidinyl compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the heteroaryl-fused pyrimidinyl compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the heteroaryl-fused pyrimidinyl compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.
摘要:
Heteroaryl-fused pyrimidinyl compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the heteroaryl-fused pyrimidinyl compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the heteroaryl-fused pyrimidinyl compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.
摘要:
Pyridin[1,2-a]pyrimidinyl compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the pyridino[1,2-a]pyrimidinyl compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the pyridino[1,2-a]pyrimidinyl compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.
摘要:
An information processing system constituted with one or more computers includes a first result storage part to store result values of operation amounts of a first device; a prediction part to generate prediction values of operation amounts of the first device during a period; a calculation part to calculate indicator values based on the prediction values; an extraction part to select a second device that substitutes the first device using the indicator values; a replacement information storage part to store correspondence information between a device before replacement and a device after replacement; an obtainment part to obtain operation amounts of the devices before and after replacement, respectively, assuming that the first device is replaced by the second device; and an output part to output information about the obtained operation amounts.
摘要:
A device control system provided herein includes: a reservation unit that receives inputs of location identification information, a use date/time, and user identification information and makes a reservation so that a user can use a location and a device disposed at the location at the use date/time; a determination unit that acquires user position information and location position information and determines whether or not a predetermined relationship is established between the position of the user and position of the location within a first time period before start of the use date/time; a control information generation unit that acquires device information including at least device identification information for identifying the device on a network and uses the acquired device information to generate control information for controlling operation of the device; and a device control unit that controls operation of the device using the control information when the predetermined relationship is established.
摘要:
A first acquisition unit acquires an event notification from an MFP and updates first device-status information. A transmission unit transmits the event notification and first reference-destination information. A switching unit switches a first access to the first reference-destination information to a second access to second reference-destination information. A second acquisition unit issues an acquisition request at a first interval, issues an acquisition request at a second interval in response to the event notification, acquires the second device-status information, and update the first device-status information.
摘要:
Tetrahydrocarboline compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the tetrahydrocarboline compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the tetrahydrocarboline compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.
摘要:
A first acquisition unit acquires an event notification from an MFP and updates first device-status information. A transmission unit transmits the event notification and first reference-destination information. A switching unit switches a first access to the first reference-destination information to a second access to second reference-destination information. A second acquisition unit issues an acquisition request at a first interval, issues an acquisition request at a second interval in response to the event notification, acquires the second device-status information, and update the first device-status information.