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221 条记录 (耗时 0.048 秒)

    Method for production of aryl-substituted annelated pyrimidines
    41.
    发明申请
    Method for production of aryl-substituted annelated pyrimidines 审中-公开
    芳基取代的环状嘧啶的制备方法

    公开(公告)号：US20100087640A1

    公开(公告)日：2010-04-08

    申请号：US12521877

    申请日：2008-01-10

    申请人： Bernd Wolf ,  Volker Maywald ,  Michael Keil ,  Manuel Budich ,  Michael Rack ,  Manfred Ehresmann

    发明人： Bernd Wolf ,  Volker Maywald ,  Michael Keil ,  Manuel Budich ,  Michael Rack ,  Manfred Ehresmann

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04

    摘要： The present invention relates to a process for preparing aryl-substituted fused pyrimidines of the general formula (I) in which L1 to L5 are H, halogen, CN, NO2, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy etc.; Y1 to Y3 are C—RY or N; RY is H or optionally substituted C1-C4-alkyl or two adjacent RY together form a ring; X is OH, Cl or Br; which comprises (i) the reaction of a 2-phenylmalonate with a compound (III) or a tautomer thereof, in the presence of a suitable base, where the alcohol, released during the reaction, of the formula R—OH is continuously removed from the reaction mixture under reduced pressure; giving a compound of the formula (I) or a salt thereof in which X is OH, and, if X in the compounds of the general formula (I) is chlorine or bromine, (ii) the reaction of the compounds of the formula (I) obtained in step (i) or the salts with a halogenating agent.

    摘要翻译： 本发明涉及制备通式（I）的芳基取代的稠合嘧啶的方法，其中L 1至L 5为H，卤素，CN，NO 2，C 1 -C 4烷基，C 1 -C 4卤代烷基，C 1 -C 4 - 烷氧基，C1-C4-卤代烷氧基等; Y1至Y3为C-RY或N; RY为H或任选取代的C 1 -C 4烷基或两个相邻的RY一起形成环; X是OH，Cl或Br; 其包括（i）2-苯基丙二酸酯与化合物（III）或其互变异构体在合适的碱的存在下反应，其中反应期间释放的醇与式R-OH的连续从 减压下的反应混合物; 得到其中X是OH的式（I）化合物或其盐，并且如果通式（I）的化合物中的X是氯或溴，则（ii）式（I）化合物 I）或与卤化剂的盐。

    Process for Preparing Fluoromethyl-Substituted Heterocyclic Compounds
    42.
    发明申请
    Process for Preparing Fluoromethyl-Substituted Heterocyclic Compounds 失效
    制备氟甲基取代的杂环化合物的方法

    公开(公告)号：US20100022782A1

    公开(公告)日：2010-01-28

    申请号：US12519032

    申请日：2007-12-20

    申请人： Thomas Zierke ,  Michael Rack

    发明人： Thomas Zierke ,  Michael Rack

    IPC分类号： C07D231/10

    CPC分类号： C07D231/14

    摘要： The present invention relates to a process for preparing fluoromethyl-substituted heterocyclic compounds of the general formula (I) in which R1 is H or F; R2 is an -[A-O]m—R3 group in which A is C2-C4-alkanediyl, R3 is C1-C4-alkyl and m is 1 or 2; by converting the corresponding chloromethyl-substituted compounds (II) in the presence of fluorinating agents, to processes for preparing the chloromethyl-substituted compounds (II), to processes for preparing amides of the general formula (IV) and to compounds of the general formulae (I) and (II).

    摘要翻译： 本发明涉及制备通式（I）的氟甲基取代的杂环化合物的方法，其中R 1为H或F; R2是其中A是C 2 -C 4烷二基，R 3是C 1 -C 4烷基，m是1或2的 - [A-O] m -R 3基团; 通过在氟化剂的存在下将相应的氯甲基取代的化合物（II）转化为制备氯甲基取代的化合物（II）的方法，制备通式（IV）的酰胺的方法和通式 （I）和（II）。

    2-Substituted 7-Aminoazolopyrimidines, Processes For Their Preparation And Their Use For Controlling Harmful Fungi, And Compositions Comprising These Compounds
    44.
    发明申请
    2-Substituted 7-Aminoazolopyrimidines, Processes For Their Preparation And Their Use For Controlling Harmful Fungi, And Compositions Comprising These Compounds 审中-公开
    2-取代的7-氨基偶氮嘧啶，其制备方法及其用于控制​​有害真菌和包含这些化合物的组合物

    公开(公告)号：US20080139581A1

    公开(公告)日：2008-06-12

    申请号：US11885536

    申请日：2006-03-02

    申请人： Wassilios Grammenos ,  Thomas Grote ,  Udo Hunger ,  Jan Klaas Lohmann ,  Bern Muller ,  Joachim Rheinheimer ,  Peter Schafer ,  Anja Schwogler ,  Michael Rack

    发明人： Wassilios Grammenos ,  Thomas Grote ,  Udo Hunger ,  Jan Klaas Lohmann ,  Bern Muller ,  Joachim Rheinheimer ,  Peter Schafer ,  Anja Schwogler ,  Michael Rack

    IPC分类号： A01N43/90 ,  A01P3/00 ,  C07D487/04

    CPC分类号： C07D487/04

    摘要： 2-Substituted 7-aminoazolopyrimidines of the formula I in which the substituents are as defined below: R1 is hydrogen, halogen, cyano, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, alkoxyalkyl, benzyloxyalkyl, alkoxyalkenyl or alkoxyalkynyl; R2 is hydrogen, halogen, cyano, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, alkoxyalkyl and alkylthioalkyl, where the carbon chains in R1 and/or R2 may be substituted according to the description; R3 is halogen, cyano, NRARB, hydroxyl, mercapto, alkyl, haloalkyl, cycloalkyl, alkoxy, alkylthio, cycloalkoxy, cycloalkylthio, carboxyl, formyl, alkylcarbonyl, alkoxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, phenyl, phenoxy, phenylthio, benzyloxy, benzylthio, alkyl-S(O)m—; A is N and CRx; Rx is hydrogen or one of the groups mentioned under R3; processes and intermediates for preparing these compounds, compositions comprising them and their use for controlling phytopathogenic harmful fungi.

    摘要翻译： 2-取代的式I的7-氨基偶氮嘧啶，其中取代基如下：R 1是氢，卤素，氰基，烷基，卤代烷基，烯基，炔基，环烷基，烷氧基，烷氧基烷基，苄氧基烷基 ，烷氧基烯基或烷氧基炔基; R 2是氢，卤素，氰基，烷基，卤代烷基，烯基，炔基，环烷基，烷氧基，烷氧基烷基和烷硫基烷基，其中R 1和/或R 2可以根据描述代替; R 3是卤素，氰基，NR B，B，羟基，巯基，烷基，卤代烷基，环烷基，烷氧基，烷硫基，环烷氧基，环烷硫基 ，羧基，甲酰基，烷基羰基，烷氧基羰基，烯氧基羰基，炔氧基羰基，苯基，苯氧基，苯硫基，苄氧基，苄硫基，烷基-S（O） A是N和CR R x是氢或R 3中提到的基团之一; 制备这些化合物的方法和中间体，包含它们的组合物及其用于控制​​植物病原性有害真菌的用途。

    Method for producing oxime ethers
    49.
    发明授权
    Method for producing oxime ethers 失效
    生产肟醚的方法

    公开(公告)号：US06680410B2

    公开(公告)日：2004-01-20

    申请号：US10257327

    申请日：2002-10-10

    申请人： Roland Götz ,  Bernd Wolf ,  Michael Rack

    发明人： Roland Götz ,  Bernd Wolf ,  Michael Rack

    IPC分类号： C07C25156

    CPC分类号： C07C249/12 ,  C07C251/38

    摘要： A process for preparing oxime ethers of the formula I, in which the substituents R1 and R2 can be identical or different and can each be cyano, alkyl, haloalkyl, cycloalkyl, phenyl and naphthyl, and R3 can be alkyl, by alkylation of oximes of the formula II under basic conditions with an alkylating agent from the group of alkyl halides, dialkyl sulfates and dialkyl carbonates, wherein the reaction is carried out in a mixture consisting of 5 to 25% by weight of polar aprotic solvents selected from the group of nitrites, N-alkylpyrrolidones, cyclic urea derivatives, dimethylformamide and dimethylacetamide, 55 to 95% by weight of nonpolar solvents selected from the group of aliphatic hydrocarbons, aromatic hydrocarbons, alkyl alkylcarboxylates and ethers, and 0 to 25% by weight of water, the contents thereof totaling 100%.

    摘要翻译： 制备式I的肟醚的方法，其中取代基R 1和R 2可以相同或不同，并且各自可以是氰基，烷基，卤代烷基，环烷基，苯基和萘基，R 3， 可以通过烷基化剂从烷基卤化物，二烷基硫酸盐和碳酸二烷基酯在碱性条件下将式II的肟烷基化，其中该反应以5至25重量％的极性非质子 选自亚硝酸盐，N-烷基吡咯烷酮，环脲衍生物，二甲基甲酰胺和二甲基乙酰胺的溶剂，55至95重量％的选自脂族烃，芳烃，烷基烷基羧酸盐和醚的非极性溶剂，和0至25％ 水重量，总含量为100％。