公开(公告)号：US09206198B2

公开(公告)日：2015-12-08

申请号：US14569858

申请日：2014-12-15

Applicant: Merck Sharp & Dohme Corp.

Inventor： Fa-Xiang Ding ,  Shuzhi Dong ,  Jessica Frie ,  Xin Gu ,  Jinlong Jiang ,  Alexander Pasternak ,  Haifeng Tang ,  Zhicai Wu ,  Yang Yu ,  Takao Suzuki

IPC: C07D471/20 ,  A61K31/435 ,  A61K31/46 ,  A61K31/5386 ,  C07D471/10 ,  A61K45/06 ,  C07D498/20 ,  A61K31/4995 ,  C07D451/00 ,  C07D519/00

CPC classification number: C07D498/20 ,  A61K31/435 ,  A61K31/46 ,  A61K31/4995 ,  A61K31/5386 ,  A61K45/06 ,  C07D451/00 ,  C07D471/10 ,  C07D471/20 ,  C07D519/00

Abstract: The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.