公开(公告)号：US07851464B2

公开(公告)日：2010-12-14

申请号：US12085057

申请日：2006-11-14

申请人： Ian M. Bell ,  Harold G. Selnick ,  Michael R. Wood ,  Cory R. Theberge ,  Craig A. Stump ,  Steven N. Gallicchio ,  C. Blair Zartman

发明人： Ian M. Bell ,  Harold G. Selnick ,  Michael R. Wood ,  Cory R. Theberge ,  Craig A. Stump ,  Steven N. Gallicchio ,  C. Blair Zartman

IPC分类号： A61K31/437 ,  A61K31/4375 ,  A61K31/438 ,  A61K31/4985 ,  A61K31/551 ,  C07D243/10 ,  C07D487/22 ,  C07D471/22 ,  C07D241/38 ,  C07D401/14

CPC分类号： C07D471/20 ,  C07D519/00

摘要： Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, E1, E2, E3, E4, E5, G1, G2, J and K are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 式I化合物（其中变量A1，A2，A3，A4，A5，A6，A7，E1，E2，E3，E4，E5，G1，G2，J和K如本文所述），其是CGRP受体的拮抗剂 并且其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20100160334A1

公开(公告)日：2010-06-24

申请号：US12718386

申请日：2010-03-05

申请人： Ian M. Bell ,  Steven N. Gallicchio ,  Graig A. Stump ,  Cory R. Theberge ,  Joseph P. Vacca ,  C. Blair Zartman ,  Xufang Zhang

发明人： Ian M. Bell ,  Steven N. Gallicchio ,  Graig A. Stump ,  Cory R. Theberge ,  Joseph P. Vacca ,  C. Blair Zartman ,  Xufang Zhang

IPC分类号： A61K31/4985 ,  C07D471/16 ,  A61P25/06

CPC分类号： C07D519/00 ,  C07D209/96 ,  C07D471/06 ,  C07D471/16 ,  C07D487/06

摘要： The present invention is directed to compounds of Formula I: I (where A1, A2, B1, B2, B3, B4, D1, D2, J, K, T, U, V, W, X, Y, Z, R4, R5a, R5b, R5c, m and n are defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及式I化合物：其中A1，A2，B1，B2，B3，B4，D1，D2，J，K，T，U，V，W，X，Y，Z， R5a，R5b，R5c，m和n在本文中定义），其可用作CGRP受体的拮抗剂，并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US20100093759A1

公开(公告)日：2010-04-15

申请号：US12595874

申请日：2008-04-11

申请人： Ian M. Bell ,  Harold G. Selnick ,  Craig A. Stump

发明人： Ian M. Bell ,  Harold G. Selnick ,  Craig A. Stump

IPC分类号： A61K31/438 ,  C07D471/20 ,  A61K31/437 ,  A61K31/506 ,  A61P25/00

CPC分类号： C07D471/20 ,  C07D519/00

摘要： Compounds of formula I: I (wherein variables A1, A2, B, m, n, J, R4, G1, G2, G3 and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 式I：I（其中变量A1，A2，B，m，n，J，R4，G1，G2，G3和Y如本文所述）是CGRP受体的拮抗剂，其可用于治疗或预防 涉及CGRP的疾病，如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US07629338B2

公开(公告)日：2009-12-08

申请号：US11800626

申请日：2007-05-07

申请人： Michael R. Wood ,  Steven N. Gallicchio ,  Harold G. Selnick ,  C. Blair Zartman ,  Ian M. Bell ,  Craig A. Stump

发明人： Michael R. Wood ,  Steven N. Gallicchio ,  Harold G. Selnick ,  C. Blair Zartman ,  Ian M. Bell ,  Craig A. Stump

IPC分类号： C07D401/12 ,  C07D409/14 ,  C07D417/12 ,  C07D471/04 ,  C07D519/00 ,  A61K31/403 ,  A61K31/407 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/4439 ,  A61K31/438 ,  A61P25/06

CPC分类号： C07D401/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D471/20 ,  C07D519/00

摘要： Compounds of formula I: (wherein variables A1, A2, A3, A4, m, n, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

公开(公告)号：US20070265225A1

公开(公告)日：2007-11-15

申请号：US11800626

申请日：2007-05-07

申请人： Michael R. Wood ,  Steven N. Gallicchio ,  Harold G. Selnick ,  C. Blair Zartman ,  Ian M. Bell ,  Craig A. Stump

发明人： Michael R. Wood ,  Steven N. Gallicchio ,  Harold G. Selnick ,  C. Blair Zartman ,  Ian M. Bell ,  Craig A. Stump

IPC分类号： C07F7/02 ,  A61K31/695 ,  A61K31/55

CPC分类号： C07D401/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D471/20 ,  C07D519/00

摘要： Compounds of formula I: (wherein variables A1, A2, A3, A4, m, n, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 式I化合物（其中变量A 1，A 2，A 3，A 4，m， n，J，Q，R 4，O，S，O，B， 6，R 7，R e，R f，R PG和Y如上所述 在本文中），其是CGRP受体的拮抗剂，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US07189722B2

公开(公告)日：2007-03-13

申请号：US10547227

申请日：2004-03-10

申请人： Ian M. Bell ,  Cory R. Theberge ,  Xu-Fang Zhang ,  C. Blair Zartman

发明人： Ian M. Bell ,  Cory R. Theberge ,  Xu-Fang Zhang ,  C. Blair Zartman

IPC分类号： A61K31/4166 ,  A61K31/498 ,  A61K31/4709 ,  A61K31/427 ,  C07D233/76 ,  C07D241/36 ,  C07D215/14 ,  C07D277/28

CPC分类号： C07D235/02 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

摘要： The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的化合物，其可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US5756497A

公开(公告)日：1998-05-26

申请号：US807307

申请日：1997-02-27

申请人： Ian M. Bell ,  Roger M. Freidinger ,  Peter D. Williams

发明人： Ian M. Bell ,  Roger M. Freidinger ,  Peter D. Williams

IPC分类号： C07D413/14 ,  C07D265/18 ,  A61K31/535

CPC分类号： C07D413/14

摘要： This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor in mammals, especially humans. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery.

公开(公告)号：US5574044A

公开(公告)日：1996-11-12

申请号：US329757

申请日：1994-10-27

申请人： Wayne J. Thompson ,  Michael F. Sugrue ,  Richard W. Ransom ,  Pierre J. Mallorga ,  Ian M. Bell ,  Anthony M. Smith

发明人： Wayne J. Thompson ,  Michael F. Sugrue ,  Richard W. Ransom ,  Pierre J. Mallorga ,  Ian M. Bell ,  Anthony M. Smith

IPC分类号： C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  A61K31/445

CPC分类号： C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12

摘要： Compounds, 1,3-dihydro-1-{1-[piperidin-4-yl]piperidin-4-yl}-2H-benzimidazol-2-ones and 1,3-dihydro-1-{4-amino-1-cyclohexyl}-2H-benzimidazol-2-ones and derivatives thereof, their preparation, method of use and pharmaceutical compositions are described. These compounds are endowed with antimuscarinic activity and are useful in the treatment and/or prevention of myopia (commonly known as nearsightedness).

摘要翻译： 化合物，1,3-二氢-1- {1- [哌啶-4-基]哌啶-4-基} -2H-苯并咪唑-2-酮和1,3-二氢-1- {4-氨基-1- 环己基} -2H-苯并咪唑-2-酮及其衍生物，其制备方法，使用方法和药物组合物。 这些化合物具有抗毒蕈碱活性，可用于治疗和/或预防近视（俗称近视）。

公开(公告)号：US08883807B2

公开(公告)日：2014-11-11

申请号：US13884632

申请日：2011-11-10

申请人： Ian M. Bell ,  Mark E. Fraley ,  Steven N. Gallicchio ,  Anthony Ginnetti ,  Helen J. Mitchell ,  Daniel V. Paone ,  Donnette D. Staas ,  Cheng Wang ,  Blair C. Zartman ,  Heather E. Stevenson

发明人： Ian M. Bell ,  Mark E. Fraley ,  Steven N. Gallicchio ,  Anthony Ginnetti ,  Helen J. Mitchell ,  Daniel V. Paone ,  Donnette D. Staas ,  Cheng Wang ,  Blair C. Zartman ,  Heather E. Stevenson

IPC分类号： A01N43/90 ,  A61K31/519 ,  A01N43/42 ,  A61K31/44 ,  C07D487/00 ,  C07D471/02 ,  C07D491/02 ,  C07D498/02 ,  C07D513/02 ,  C07D515/02 ,  A61K31/506 ,  C07D471/04 ,  C07D487/04

CPC分类号： C07D471/04 ,  A61K31/506 ,  C07D487/04

摘要： The present invention is directed to piperidinone carboxamide indane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的哌啶酮羧酰胺二氢化茚衍生物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。

公开(公告)号：US08754096B2

公开(公告)日：2014-06-17

申请号：US13293166

申请日：2011-11-10

申请人： Ian M. Bell ,  Mark E. Fraley ,  Steven N. Gallicchio ,  Anthony Ginnetti ,  Helen J. Mitchell ,  Daniel V. Paone ,  Donnette D. Staas ,  Heather E. Stevenson ,  Cheng Wang ,  C. Blair Zartman

发明人： Ian M. Bell ,  Mark E. Fraley ,  Steven N. Gallicchio ,  Anthony Ginnetti ,  Helen J. Mitchell ,  Daniel V. Paone ,  Donnette D. Staas ,  Heather E. Stevenson ,  Cheng Wang ,  C. Blair Zartman

IPC分类号： A61K31/4545 ,  A61K31/527 ,  A61P25/06 ,  C07D471/20

CPC分类号： A61K31/4545 ,  A61K31/435 ,  A61K31/438 ,  C07D471/10 ,  C07D471/20

摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的哌啶酮羧酰胺氮杂茚衍生物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。