公开(公告)号：US20050019879A1

公开(公告)日：2005-01-27

申请号：US10606300

申请日：2003-06-25

申请人： Danilo Porro ,  Michael Sauer

发明人： Danilo Porro ,  Michael Sauer

IPC分类号： C12N15/09 ,  C12N1/19 ,  C12N9/02 ,  C12N9/04 ,  C12N9/18 ,  C12N15/52 ,  C12N15/53 ,  C12N15/55 ,  C12P17/04 ,  C12R1/645 ,  C12N1/18

CPC分类号： C12N9/001 ,  C12N9/0006 ,  C12N9/18 ,  C12N15/52 ,  C12P17/04

摘要： Herein is disclosed a method of generating ascorbic acid from yeast. In one embodiment, the yeast is a Zygosaccharomyces spp. or a Kluyveromyces spp. growing in a medium comprising an ascorbic acid precursor. In a second embodiment the yeast is a recombinant yeast growing in a medium comprising an ascorbic acid precursor. Preferably the recombinant yeast is transformed with a coding region encoding an enzyme selected from L-galactose dehydrogenase (LGDH), L-galactono-1,4-lactone dehydrogenase (AGD), D-arabinose dehydrogenase (ARA), D-arabinono-1,4-lactone oxidase (ALO) or L-gulono-1,4-lactone oxidase (RGLO). The ascorbic acid precursor is preferably D-glucose, L-galactose, L-galactono-1,4-lactone, or L-gulono-1,4-lactone. In another preferred embodiment the ascorbic acid is accumulated in the medium at levels greater than background. Preferably, the yield of the conversion of the precursor to ascorbic acid is preferably at least about 35%.

公开(公告)号：USD439979S1

公开(公告)日：2001-04-03

申请号：US29107517

申请日：1999-07-07

申请人： Michael Strobel ,  Michael Sauer

设计人： Michael Strobel ,  Michael Sauer

公开(公告)号：US5545968A

公开(公告)日：1996-08-13

申请号：US392895

申请日：1995-05-04

申请人： Peter Hilfinger ,  Gerhard Kressner ,  Michael Sauer

发明人： Peter Hilfinger ,  Gerhard Kressner ,  Michael Sauer

IPC分类号： A61C17/22 ,  H01M10/42

CPC分类号： A61C17/22 ,  A61C17/224 ,  Y10T29/53283

摘要： The invention is directed to a motor-powered appliance 10 for personal use as, for example, an appliance for oral or dental hygiene, a shaver or the like, with a housing 12 for accommodating the drive means 20 as well as at least one rechargeable energy-storage cell 18. The housing 12 is composed of at least two housing sections 13, 14 sealingly connectible with each other. The appliance 10 has an associated case structure 22 incorporating in particular means 24 for charging the energy-storage cells 18, or in particular means 26 for the storage of attachments for the appliance 10. The case structure 22 includes two abutment means which, in forming an integral part of the case structure 22, provide a tool for severing the housing sections 13, 14.

摘要翻译： PCT No.PCT / DE93 / 00805 Sec。 371日期：1995年5月4日 102（e）日期1995年5月4日PCT提交1993年9月3日PCT公布。 公开号WO94 / 05228 日期：1994年3月17日本发明涉及一种用于个人用途的电动机具10，例如用于口腔或牙齿卫生，剃须刀等的器具，还具有用于容纳驱动装置20的壳体12 作为至少一个可再充电能量存储单元18.壳体12由至少两个彼此密封连接的壳体部分13,14组成。 器具10具有相关联的外壳结构22，其特别地包括用于对能量存储单元18进行充电的装置24，或特别地用于存储用于器具10的附件的装置26.壳体结构22包括两个邻接装置， 壳体结构22的整体部分提供了用于切断壳体部分13,14的工具。

公开(公告)号：US4658952A

公开(公告)日：1987-04-21

申请号：US626455

申请日：1984-06-29

申请人： Dieter Grundken ,  Manfred Redder ,  Franz Roling ,  Michael Sauer ,  Gunther-Dietmar Schoop

发明人： Dieter Grundken ,  Manfred Redder ,  Franz Roling ,  Michael Sauer ,  Gunther-Dietmar Schoop

IPC分类号： B65G19/28

CPC分类号： B65G19/28

摘要： A scraper-chain conveyor channel section comprises a pair of side walls and a floor plate extending between the side walls and connecting the side walls together. Each of the side walls has upper, lower and intermediate inwardly-extending flanges. The floor plate is connected to the intermediate flanges of the two side walls. Each of the side walls is constituted by an upper profiled bar and a lower profiled bar, each of the profiled bars being a generally U-shaped rolled section. Each of the lower profiled bars has a bottom flange and a top flange parallel to the bottom flange. The top flange of each lower profiled bar forms a support surface for the associated upper profiled bar, and constitutes part of the intermediate flange of the associated side wall. Each of the side walls is provided with a connecting bar for laterally supporting the associated upper profiled bar. Each of the connecting bars is secured to the exterior of the associated lower profiled bar, and projects upwardly beyond the top flange of that lower profiled bar.

摘要翻译： 刮板链输送通道部分包括一对侧壁和在侧壁之间延伸并将侧壁连接在一起的地板。 每个侧壁具有上，下和中间向内延伸的凸缘。 地板连接到两个侧壁的中间凸缘。 每个侧壁由上成型棒和下成型棒构成，每个成型棒都是大致U形的轧制部分。 每个下型材具有底部凸缘和平行于底部凸缘的顶部凸缘。 每个下成型杆的顶部凸缘形成用于相关联的上型材的支撑表面，并且构成相关侧壁的中间凸缘的一部分。 每个侧壁设置有用于横向支撑相关联的上型材的连杆。 每个连接杆固定到相关联的下成型杆的外部，并向上突出超过该下成型杆的顶部凸缘。

公开(公告)号：US09561092B2

公开(公告)日：2017-02-07

申请号：US13356831

申请日：2012-01-24

申请人： Michael Sauer ,  Oliver Greve

发明人： Michael Sauer ,  Oliver Greve

IPC分类号： A61C17/22

CPC分类号： A61C17/222 ,  A61C17/22 ,  A61C17/225

摘要： An attachment for an oral hygiene device is disclosed. The attachment includes a housing; a shaft element movably arranged within the housing and arranged for being coupled to a drive shaft of a handle of the oral hygiene device; and a flexible sealing element attached to the shaft element. The flexible sealing element is arranged to seal a cavity within the attachment intended for accommodating at least a part of the drive shaft in an attached state.

摘要翻译： 公开了一种用于口腔卫生装置的附件。 附件包括壳体; 轴元件，其可移动地布置在所述壳体内并且布置成联接到所述口腔卫生装置的手柄的驱动轴; 以及附接到轴元件的柔性密封元件。 柔性密封元件布置成密封用于在附接状态下容纳至少一部分驱动轴的附件内的空腔。

公开(公告)号：US09408682B2

公开(公告)日：2016-08-09

申请号：US12430487

申请日：2009-04-27

申请人： Titus Lanz ,  Michael Sauer

发明人： Titus Lanz ,  Michael Sauer

IPC分类号： A61D3/00 ,  A61B5/055 ,  A61B6/03

CPC分类号： A61D3/00 ,  A61B5/0555 ,  A61B6/03 ,  A61B2503/40

摘要： A device and a method for imaging an animal including an animal holding device for keeping the animal immobile and at a desired temperature during the scanning operation for imaging the animal in real-time in a non-destructive manner.

摘要翻译： 一种用于成像动物的装置和方法，所述装置和方法包括用于保持动物不动的动物保持装置，并且在扫描操作期间以非破坏性的方式实时成像动物。

公开(公告)号：US09320453B2

公开(公告)日：2016-04-26

申请号：US13590842

申请日：2012-08-21

申请人： Titus Lanz ,  Michael Sauer ,  Frank Resmer

发明人： Titus Lanz ,  Michael Sauer ,  Frank Resmer

IPC分类号： A61B5/055 ,  A61B6/04 ,  A61D7/04 ,  A01K1/06 ,  A61B6/00

CPC分类号： A61B5/0555 ,  A01K1/0613 ,  A61B6/0407 ,  A61B6/0421 ,  A61B6/4417 ,  A61B6/508 ,  A61D7/04

摘要： An imaging device for imaging an anaesthetized animal such as a rodent (rats or mice or other animals), with the device having a split array coil capable of providing at least two channels for use in a restraining assembly with animal bed for magnetic resonance imaging (MRI) the animal in real-time in a non-destructive manner.

摘要翻译： 用于对麻醉动物（例如啮齿动物（大鼠或小鼠或其他动物）进行成像的成像装置），该装置具有能够提供至少两个通道的分裂阵列线圈，用于具有用于磁共振成像的动物床的约束组件 MRI）动物实时以非破坏性的方式。

公开(公告)号：US08702740B2

公开(公告)日：2014-04-22

申请号：US12793964

申请日：2010-06-04

申请人： Martin Oberlaender ,  Michael Sauer ,  Uwe Bacher ,  Michael Staehler

发明人： Martin Oberlaender ,  Michael Sauer ,  Uwe Bacher ,  Michael Staehler

IPC分类号： A61B17/32

CPC分类号： A61B17/1611

摘要： A medical punch with a hollow shaft, a tool point that is positioned on the distal end of the shaft and includes a rigid cutting part and a cutting part that can slide with respect to the rigid cutting part, and with a handle positioned on the proximal end of the shaft, such that the displaceable cutting part and the handle are operatively connected with one another by a push/pull device that is displaceably mounted in the hollow shaft and an anti-tilt mechanism is positioned on the tool point to stabilize the cutting parts in their axially parallel alignment to one another. The rigid cutting part includes a sleeve-shaped proximal portion that encloses the displaceable cutting part and a distal punch portion configured as a single unit with the sleeve-shaped portion and that the rigid cutting part should be detachably connected with the hollow shaft by a coupling mechanism formed on the sleeve-shaped portion.

摘要翻译： 具有空心轴的医用冲头，位于轴的远端上的工具点，其包括可相对于刚性切削部分滑动的刚性切削部分和切削部分，以及位于近端 使得可移动的切割部分和手柄通过可移动地安装在中空轴中的推/拉装置彼此操作地连接，并且防倾斜机构定位在工具点上以稳定切割 部件彼此轴向平行对准。 刚性切割部分包括套筒形近端部分，其包围可移动切割部分和远侧冲头部分，该远端冲头部分构造为具有套筒形部分的单个单元，并且刚性切割部分应通过联接器与中空轴可拆卸地连接 机构形成在套筒形部分上。

公开(公告)号：US08702601B2

公开(公告)日：2014-04-22

申请号：US13410695

申请日：2012-03-02

申请人： Martin Oberlaender ,  Michael Sauer ,  Vincent Beysang

发明人： Martin Oberlaender ,  Michael Sauer ,  Vincent Beysang

IPC分类号： A61B1/32

CPC分类号： A61B17/0293 ,  A61B17/0206 ,  A61B17/3439 ,  A61B17/3462 ,  A61B2017/3484 ,  A61B2017/349

摘要： A medical access device for creating an access to a body for minimally invasive intervention has a hollow body assembled from at least two parts having longitudinal extending edges. Each part has a distal body portion and at an angle to the latter a proximal body portion. A locking mechanism locks the assembled proximal hollow body portions. The locking mechanism has a hook projecting from an edge of a proximal body. A nose of the hook can enter from proximal to distal in a recess in an edge joining said edge having said hook.

摘要翻译： 用于创建对身体进行微创干预的医疗接入装置具有由具有纵向延伸边缘的至少两个部分组装的中空体。 每个部分具有远侧主体部分，并且与远端主体部分成一角度。 锁定机构锁定组装的近端中空主体部分。 锁定机构具有从近体的边缘突出的钩。 钩子的鼻子可以在连接具有所述钩子的所述边缘的边缘的凹部中从近端到远端进入。

公开(公告)号：US08475485B2

公开(公告)日：2013-07-02

申请号：US12507476

申请日：2009-07-22

申请人： Elmar Teichtmann ,  Michael Sauer

发明人： Elmar Teichtmann ,  Michael Sauer

IPC分类号： A61B17/34

CPC分类号： A61B17/3462 ,  A61B2017/3464

摘要： A medical instrument has a cannula, a seal disposed in the cannula. An expansion device serves for expanding the opening in the seal for guiding shafts of other instruments of greater diameter in a sealed manner through the expanded opening. The expansion device has an expansion cone with a plurality of slats mounted pivotably on an annular body at a first end thereof, a second end of the slats, being connected to the seal in an area of the opening. The slats can either be connected at its first ends to the annular body via spherical heads engaged into corresponding openings in the annular body or the slats are connected at their ends via film hinges to the annular body.

摘要翻译： 医疗器具具有插管，设置在套管中的密封件。 膨胀装置用于扩大密封件中的开口，用于通过膨胀的开口以密封的方式引导具有较大直径的其它仪器的轴。 膨胀装置具有膨胀锥体，多个板条在其第一端处可旋转地安装在环形主体上，板条的第二端在开口的区域中连接到密封件。 板条可以通过与环形体接合到相应开口中的球形头部在其第一端连接到环形体，或者板条通过薄膜铰链连接到环形体。